{"id":"https://openalex.org/W4406728207","doi":"https://doi.org/10.1109/access.2025.3532846","title":"A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points","display_name":"A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406728207","doi":"https://doi.org/10.1109/access.2025.3532846"},"language":"en","primary_location":{"id":"doi:10.1109/access.2025.3532846","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3532846","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2025.3532846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102825181","display_name":"Anna Procopio","orcid":"https://orcid.org/0000-0002-3639-8714"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Procopio","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3639-8714","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038540836","display_name":"Annarita Tedesco","orcid":"https://orcid.org/0000-0001-7242-701X"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annarita Tedesco","raw_affiliation_strings":["Department of Public Health, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7242-701X","affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092260905","display_name":"Fabrizio Lo Regio","orcid":"https://orcid.org/0009-0003-9307-8340"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Lo Regio","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0009-0003-9307-8340","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070427663","display_name":"Giuseppe Cesarelli","orcid":"https://orcid.org/0000-0001-8303-5900"},"institutions":[{"id":"https://openalex.org/I183638586","display_name":"Parthenope University of Naples","ror":"https://ror.org/05pcv4v03","country_code":"IT","type":"education","lineage":["https://openalex.org/I183638586"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Cesarelli","raw_affiliation_strings":["Department of Engineering, University of Naples &#x201C;Parthenope&#x201D;, Naples, Italy","Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8303-5900","affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Naples &#x201C;Parthenope&#x201D;, Naples, Italy","institution_ids":["https://openalex.org/I183638586"]},{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044617873","display_name":"Leandro Donisi","orcid":"https://orcid.org/0000-0002-9746-2265"},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leandro Donisi","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9746-2265","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018342706","display_name":"Carlo Ricciardi","orcid":"https://orcid.org/0000-0001-7290-6432"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Ricciardi","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7290-6432","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042934091","display_name":"Alessio Merola","orcid":"https://orcid.org/0000-0002-8728-2084"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Merola","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8728-2084","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066195982","display_name":"Alfonso Maria Ponsiglione","orcid":"https://orcid.org/0000-0003-1346-515X"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Maria Ponsiglione","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1346-515X","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101721923","display_name":"Maria Romano","orcid":"https://orcid.org/0000-0003-1133-1115"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Romano","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1133-1115","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036698807","display_name":"Francesco Montefusco","orcid":"https://orcid.org/0000-0002-3264-9686"},"institutions":[{"id":"https://openalex.org/I183638586","display_name":"Parthenope University of Naples","ror":"https://ror.org/05pcv4v03","country_code":"IT","type":"education","lineage":["https://openalex.org/I183638586"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Montefusco","raw_affiliation_strings":["Department of Economics, Law, Cybersecurity, and Sports Sciences, Universit&#x00E1; degli Studi di Napoli Parthenope, Nola, Naples, Italy","Department of Economics, Law, Cybersecurity, and Sports Sciences, Universit&#x00E0; degli Studi di Napoli Parthenope, Nola, NA, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3264-9686","affiliations":[{"raw_affiliation_string":"Department of Economics, Law, Cybersecurity, and Sports Sciences, Universit&#x00E1; degli Studi di Napoli Parthenope, Nola, Naples, Italy","institution_ids":["https://openalex.org/I183638586"]},{"raw_affiliation_string":"Department of Economics, Law, Cybersecurity, and Sports Sciences, Universit&#x00E0; degli Studi di Napoli Parthenope, Nola, NA, Italy","institution_ids":["https://openalex.org/I183638586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085080876","display_name":"Carlo Cosentino","orcid":"https://orcid.org/0000-0001-5768-1829"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Cosentino","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5768-1829","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E3; degli Studi &#x201C;Magna Gr&#x00E6;cia&#x201D; di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Universit&#x00E0; degli Studi Magna Gr&#x00E6;cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030101234","display_name":"Francesco Amato","orcid":"https://orcid.org/0000-0002-9053-3139"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Amato","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9053-3139","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":5.845,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.9642291,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"17630","last_page":"17651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9190000295639038,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9190000295639038,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uniqueness","display_name":"Uniqueness","score":0.7613893747329712},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.7317008376121521},{"id":"https://openalex.org/keywords/multivariable-calculus","display_name":"Multivariable calculus","score":0.7228748798370361},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5624977946281433},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.49811339378356934},{"id":"https://openalex.org/keywords/exponential-stability","display_name":"Exponential stability","score":0.48669153451919556},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.4601384699344635},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4524941146373749},{"id":"https://openalex.org/keywords/loop","display_name":"Loop (graph theory)","score":0.4438692629337311},{"id":"https://openalex.org/keywords/equilibrium-point","display_name":"Equilibrium point","score":0.4322620928287506},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3949472904205322},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3846225142478943},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.1945095658302307},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.1559874415397644},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13908898830413818},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.1359700858592987},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12201452255249023},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.09294569492340088},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08398950099945068},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.06928279995918274}],"concepts":[{"id":"https://openalex.org/C2777021972","wikidata":"https://www.wikidata.org/wiki/Q22976830","display_name":"Uniqueness","level":2,"score":0.7613893747329712},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.7317008376121521},{"id":"https://openalex.org/C117312493","wikidata":"https://www.wikidata.org/wiki/Q2035437","display_name":"Multivariable calculus","level":2,"score":0.7228748798370361},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5624977946281433},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.49811339378356934},{"id":"https://openalex.org/C167964875","wikidata":"https://www.wikidata.org/wiki/Q17011487","display_name":"Exponential stability","level":3,"score":0.48669153451919556},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.4601384699344635},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4524941146373749},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.4438692629337311},{"id":"https://openalex.org/C94766913","wikidata":"https://www.wikidata.org/wiki/Q1530271","display_name":"Equilibrium point","level":3,"score":0.4322620928287506},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3949472904205322},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3846225142478943},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.1945095658302307},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.1559874415397644},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13908898830413818},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.1359700858592987},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12201452255249023},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.09294569492340088},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08398950099945068},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.06928279995918274},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/access.2025.3532846","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3532846","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5acfd3384b7547ec92a48b65b04e221a","is_oa":true,"landing_page_url":"https://doaj.org/article/5acfd3384b7547ec92a48b65b04e221a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 17630-17651 (2025)","raw_type":"article"},{"id":"pmh:oai:ricerca.uniparthenope.it:11367/143638","is_oa":false,"landing_page_url":"https://hdl.handle.net/11367/143638","pdf_url":null,"source":{"id":"https://openalex.org/S4377196432","display_name":"CINECA IRIS Institutial research information system (Parthenope University of Naples)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183638586","host_organization_name":"Parthenope University of Naples","host_organization_lineage":["https://openalex.org/I183638586"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/access.2025.3532846","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2025.3532846","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W69586344","https://openalex.org/W353076664","https://openalex.org/W906676016","https://openalex.org/W1527571715","https://openalex.org/W1536678168","https://openalex.org/W1992350848","https://openalex.org/W1996701078","https://openalex.org/W2008918308","https://openalex.org/W2010488656","https://openalex.org/W2026476990","https://openalex.org/W2033552457","https://openalex.org/W2041603328","https://openalex.org/W2055308128","https://openalex.org/W2055687053","https://openalex.org/W2056861732","https://openalex.org/W2058683320","https://openalex.org/W2060346337","https://openalex.org/W2062689336","https://openalex.org/W2070658593","https://openalex.org/W2071466153","https://openalex.org/W2071527993","https://openalex.org/W2077670298","https://openalex.org/W2080486913","https://openalex.org/W2084224765","https://openalex.org/W2084521532","https://openalex.org/W2086061329","https://openalex.org/W2100486339","https://openalex.org/W2115806147","https://openalex.org/W2119958909","https://openalex.org/W2126921853","https://openalex.org/W2133254839","https://openalex.org/W2137614665","https://openalex.org/W2147342239","https://openalex.org/W2172227046","https://openalex.org/W2309046008","https://openalex.org/W2408596163","https://openalex.org/W2499601348","https://openalex.org/W2499603195","https://openalex.org/W2508850390","https://openalex.org/W2558377774","https://openalex.org/W2586394106","https://openalex.org/W2594623311","https://openalex.org/W2742936021","https://openalex.org/W2783410109","https://openalex.org/W2784207779","https://openalex.org/W2784356206","https://openalex.org/W2799954755","https://openalex.org/W2806810105","https://openalex.org/W2968121657","https://openalex.org/W2969036547","https://openalex.org/W2998493968","https://openalex.org/W2998675358","https://openalex.org/W2999653018","https://openalex.org/W3012033770","https://openalex.org/W3036836591","https://openalex.org/W3038958977","https://openalex.org/W3118640947","https://openalex.org/W3132255180","https://openalex.org/W3136254756","https://openalex.org/W3176003056","https://openalex.org/W3176165488","https://openalex.org/W3182322274","https://openalex.org/W3199074364","https://openalex.org/W4213337311","https://openalex.org/W4290975842","https://openalex.org/W4294811454","https://openalex.org/W4302405331","https://openalex.org/W4309958134","https://openalex.org/W4310384199","https://openalex.org/W4313525022","https://openalex.org/W4320498299","https://openalex.org/W4372218761","https://openalex.org/W4384297741","https://openalex.org/W4385724385","https://openalex.org/W4385986528","https://openalex.org/W4388020660","https://openalex.org/W4391221209","https://openalex.org/W4391690479","https://openalex.org/W4392908047","https://openalex.org/W4400745396","https://openalex.org/W6632825267","https://openalex.org/W6731597967"],"related_works":["https://openalex.org/W1978738522","https://openalex.org/W2095028518","https://openalex.org/W2377228964","https://openalex.org/W2059311322","https://openalex.org/W2536963663","https://openalex.org/W2057482994","https://openalex.org/W1564602840","https://openalex.org/W1989732506","https://openalex.org/W1988317900","https://openalex.org/W2115648193"],"abstract_inverted_index":{"The":[0,101,129],"study":[1,301],"of":[2,38,48,64,85,89,131,147,176,184,188,217,222,247,257,274,283,293,302,305,315],"homeostatic":[3,219,296,365],"equilibrium":[4,220,297],"is":[5,160,231,334],"a":[6,61,74,86,104,108,133,163,192,196,244,352,360,368],"key":[7],"concern":[8],"in":[9,34,191,207,267],"several":[10],"fields,":[11],"from":[12,94,343,367],"physiology":[13],"and":[14,18,40,81,116,118,174,198,214,251,298,340],"biology":[15],"to":[16,28,54,77,97,154,161,167,171,201,278,338,347,363],"medicine":[17],"biomedical":[19],"engineering.":[20],"Control":[21],"theory":[22],"approaches":[23,170],"can":[24,59],"provide":[25],"effective":[26,169],"strategies":[27],"model":[29,78,135,190,225],"physiological":[30,65,91,156,285],"control":[31,92,179,255,366],"systems,":[32,93],"helping":[33],"understanding":[35,149,364],"the":[36,45,70,79,83,95,98,120,127,142,145,150,158,172,182,185,189,210,218,223,228,239,254,258,263,272,275,280,291,300,303,309,313,319,331,335,344],"dynamics":[37,80,282],"bio-":[39],"physio-logical":[41],"regulation":[42],"processes.":[43],"However,":[44],"intrinsic":[46],"complexity":[47],"living":[49],"systems":[50,286,327],"makes":[51,358],"it":[52,359],"difficult":[53],"identify":[55],"unified":[56,353],"biomodels":[57],"that":[58],"represent":[60,339],"wide":[62,87],"variety":[63],"systems.":[66],"In":[67],"this":[68,205,208],"context,":[69,194],"present":[71],"work":[72],"proposes":[73],"general":[75,134,193,224],"framework":[76,102,166,230,277],"describe":[82],"behavior":[84],"class":[88],"multivariable":[90,284,354],"molecular":[96,345],"whole-organ":[99],"scale.":[100],"adopts":[103],"structure":[105],"based":[106],"on":[107,308],"closed-loop":[109],"topology":[110],"taking":[111],"into":[112],"account":[113],"multiple":[114],"inputs":[115],"outputs":[117],"with":[119],"negative":[121],"feedback":[122],"action":[123],"intrinsically":[124],"embedded":[125],"within":[126],"model.":[128],"development":[130],"such":[132],"has":[136],"at":[137,287],"least":[138],"three":[139],"important":[140],"repercussions:":[141],"first":[143,336],"concerns":[144],"possibility":[146],"better":[148],"basic":[151],"mechanisms":[152],"common":[153,164],"many":[155],"systems;":[157,180],"second":[159],"develop":[162],"theoretical":[165,229],"enable":[168],"analysis":[173],"design":[175],"synthetic":[177],"biological":[178],"finally,":[181],"investigation":[183],"structural":[186],"properties":[187,216],"allows":[195],"guided":[197],"simplified":[199],"application":[200],"specific":[202],"cases.":[203],"To":[204],"regard,":[206],"paper,":[209],"existence,":[211],"possible":[212],"uniqueness":[213],"stability":[215],"points":[221],"are":[226],"investigated;":[227],"then":[232],"illustrated":[233],"through":[234],"two":[235],"real-world":[236],"case-studies:":[237],"(i)":[238],"PI3K/AKT/mTOR":[240],"pathway":[241],"nonlinear":[242],"dynamics,":[243],"critical":[245],"regulator":[246],"cellular":[248],"growth,":[249],"proliferation,":[250],"survival;":[252],"(ii)":[253],"mechanism":[256],"neuromuscular":[259],"stretch":[260],"reflex,":[261],"among":[262],"prime":[264],"triggers":[265],"implicated":[266],"postural":[268],"control.":[269],"Results":[270],"proved":[271],"capability":[273],"proposed":[276,332],"capture":[279],"intricate":[281],"different":[288],"scales,":[289],"highlighting":[290],"existence":[292],"asymptotically":[294],"stable":[295],"allowing":[299],"impact":[304],"transmission":[306],"delays":[307],"system\u2019s":[310],"stability.":[311],"At":[312],"best":[314],"authors\u2019":[316],"knowledge,":[317],"following":[318],"paper":[320],"Ponsiglione":[321],"et":[322],"al.":[323],"(2023)":[324],"where":[325,328],"monovariable":[326],"dealt":[329],"with,":[330],"methodology":[333],"attempt":[337],"investigate":[341],"homeostasis":[342],"up":[346],"systemic":[348],"level":[349],"by":[350],"exploiting":[351],"biomodeling":[355],"architecture,":[356],"which":[357],"novel":[361],"approach":[362],"broader":[369],"perspective.":[370]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
