{"id":"https://openalex.org/W4405219011","doi":"https://doi.org/10.1109/access.2024.3514912","title":"Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning","display_name":"Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning","publication_year":2024,"publication_date":"2024-12-11","ids":{"openalex":"https://openalex.org/W4405219011","doi":"https://doi.org/10.1109/access.2024.3514912"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3514912","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3514912","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2024.3514912","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113893490","display_name":"Sajid Naveed","orcid":"https://orcid.org/0000-0003-1815-7156"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Sajid Naveed","raw_affiliation_strings":["Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-1815-7156","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]},{"raw_affiliation_string":"Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008302404","display_name":"Mujtaba Husnain","orcid":"https://orcid.org/0000-0002-9964-4716"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mujtaba Husnain","raw_affiliation_strings":["Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-9964-4716","affiliations":[{"raw_affiliation_string":"Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]},{"raw_affiliation_string":"Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040966539","display_name":"Ali Samad","orcid":"https://orcid.org/0000-0001-9284-358X"},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]},{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK","SA"],"is_corresponding":false,"raw_author_name":"Ali Samad","raw_affiliation_strings":["Department of Data Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]},{"raw_affiliation_string":"Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016810573","display_name":"Amna Ikram","orcid":"https://orcid.org/0000-0003-4848-5070"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]},{"id":"https://openalex.org/I2800060998","display_name":"Government Sadiq College Women University","ror":"https://ror.org/01zp49f50","country_code":"PK","type":"education","lineage":["https://openalex.org/I2800060998"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amna Ikram","raw_affiliation_strings":["Department of Computer Science, Government Sadiq College Women University, Bahawalpur, Pakistan","Department of Data Science, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-4848-5070","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Government Sadiq College Women University, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I2800060998"]},{"raw_affiliation_string":"Department of Data Science, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hina Afreen","orcid":"https://orcid.org/0009-0006-9656-9286"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]},{"id":"https://openalex.org/I2800060998","display_name":"Government Sadiq College Women University","ror":"https://ror.org/01zp49f50","country_code":"PK","type":"education","lineage":["https://openalex.org/I2800060998"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hina Afreen","raw_affiliation_strings":["Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalnagar Campus, Bahawalnagar, Pakistan","Department of Computer Science, Government Sadiq College Women University, Bahawalpur, Pakistan"],"raw_orcid":"https://orcid.org/0009-0006-9656-9286","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalnagar Campus, Bahawalnagar, Pakistan","institution_ids":["https://openalex.org/I174731842"]},{"raw_affiliation_string":"Department of Computer Science, Government Sadiq College Women University, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I2800060998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060521240","display_name":"Ghulam Gilanie","orcid":"https://orcid.org/0000-0001-6880-8506"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ghulam Gilanie","raw_affiliation_strings":["Department of Artificial Intelligence, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalnagar Campus, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-6880-8506","affiliations":[{"raw_affiliation_string":"Department of Artificial Intelligence, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]},{"raw_affiliation_string":"Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalnagar Campus, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059877458","display_name":"Najah Alsubaie","orcid":"https://orcid.org/0000-0002-6381-9019"},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]},{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK","SA"],"is_corresponding":false,"raw_author_name":"Najah Alsubaie","raw_affiliation_strings":["Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), P.O. Box 84428, Riyadh, Saudi Arabia","Department of Artificial Intelligence, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-6381-9019","affiliations":[{"raw_affiliation_string":"Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), P.O. Box 84428, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Faculty of Computing, The Islamia University of Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5113893490"],"corresponding_institution_ids":["https://openalex.org/I174731842"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.1549,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.79730672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"10398","last_page":"10411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9524999856948853,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.68327397108078},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6374212503433228},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.582171618938446},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.41795527935028076},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3499617576599121},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.19344747066497803},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18793460726737976},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.11343100666999817}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.68327397108078},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6374212503433228},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.582171618938446},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.41795527935028076},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3499617576599121},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.19344747066497803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18793460726737976},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11343100666999817}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2024.3514912","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3514912","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:86e13943cc3b4aa6b58cdaf3776d099a","is_oa":true,"landing_page_url":"https://doaj.org/article/86e13943cc3b4aa6b58cdaf3776d099a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 13, Pp 10398-10411 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3514912","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3514912","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1641586021","display_name":null,"funder_award_id":"PNURSP2024R321","funder_id":"https://openalex.org/F4320322484","funder_display_name":"Princess Nourah Bint Abdulrahman University"}],"funders":[{"id":"https://openalex.org/F4320322484","display_name":"Princess Nourah Bint Abdulrahman University","ror":"https://ror.org/05b0cyh02"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1934704664","https://openalex.org/W1979897730","https://openalex.org/W2011474181","https://openalex.org/W2018044006","https://openalex.org/W2108068107","https://openalex.org/W2129860849","https://openalex.org/W2257254975","https://openalex.org/W2407075689","https://openalex.org/W2471711949","https://openalex.org/W2785059970","https://openalex.org/W2807463161","https://openalex.org/W2892035503","https://openalex.org/W2898789672","https://openalex.org/W2899849645","https://openalex.org/W2903461962","https://openalex.org/W2906755148","https://openalex.org/W2955502047","https://openalex.org/W2963046727","https://openalex.org/W2965750004","https://openalex.org/W2995320383","https://openalex.org/W3014321973","https://openalex.org/W3021338900","https://openalex.org/W3097904695","https://openalex.org/W3108380528","https://openalex.org/W3116278528","https://openalex.org/W3121446144","https://openalex.org/W3137962378","https://openalex.org/W3154997013","https://openalex.org/W3201083518","https://openalex.org/W4210427880","https://openalex.org/W4220763470","https://openalex.org/W4281572205","https://openalex.org/W4309278777","https://openalex.org/W4310213180","https://openalex.org/W4312768333","https://openalex.org/W4319321301","https://openalex.org/W4321015976","https://openalex.org/W4321207573","https://openalex.org/W4321350041","https://openalex.org/W4321452726","https://openalex.org/W4360608719","https://openalex.org/W4362584099","https://openalex.org/W4362657842","https://openalex.org/W4375951874","https://openalex.org/W4379384029","https://openalex.org/W4381570081","https://openalex.org/W4383955190","https://openalex.org/W4385224149","https://openalex.org/W4385683829","https://openalex.org/W4387911035","https://openalex.org/W4388665775","https://openalex.org/W4390415095","https://openalex.org/W4390446498","https://openalex.org/W4390826623","https://openalex.org/W4391974547","https://openalex.org/W4392125086","https://openalex.org/W4392285451","https://openalex.org/W4392387866","https://openalex.org/W4392854166","https://openalex.org/W4394728976","https://openalex.org/W4394768142","https://openalex.org/W4398150979","https://openalex.org/W6736161267"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W3215138031","https://openalex.org/W3009238340","https://openalex.org/W4360585206","https://openalex.org/W4321369474","https://openalex.org/W4285208911","https://openalex.org/W3082895349","https://openalex.org/W4213079790","https://openalex.org/W2248239756","https://openalex.org/W3086377361"],"abstract_inverted_index":{"Glioblastoma":[0],"(GBM),":[1],"a":[2,128,221,225],"common":[3],"cancer":[4,77,83,269],"of":[5,17,48,51,55,76,150,177,191,214,231,265],"the":[6,46,65,175,183,192,207,212,256,258,263,274],"central":[7],"nervous":[8],"system":[9,124,194,259],"(CNS),":[10],"is":[11],"considered":[12],"incurable":[13],"worldwide.":[14],"The":[15,53,189],"treatment":[16,47,179],"GBM":[18,155,215,268],"varies":[19],"from":[20],"patient":[21],"to":[22,31,112,234,255,276],"patient,":[23],"as":[24,64],"conventional":[25],"medical":[26,281],"treatments":[27],"do":[28],"not":[29],"apply":[30],"all":[32],"patients":[33],"with":[34,154,220,241],"similar":[35],"symptoms.":[36],"Therefore,":[37],"drug":[38,78,121,136,278],"efficacy":[39,122,279],"recommendation":[40,123,193],"systems":[41],"are":[42,94,195,238],"very":[43],"useful":[44],"in":[45,58,108,114,210],"various":[49],"types":[50],"cancers.":[52],"Genomics":[54],"Drug":[56],"Sensitivity":[57],"Cancer":[59],"(GDSC)":[60],"database":[61],"was":[62,125,156],"used":[63],"primary":[66],"data":[67],"source,":[68],"containing":[69],"135,242":[70],"cell":[71,84,87],"line-drug":[72],"interactions,":[73],"inhibitory":[74,145],"concentration":[75,146],"for":[79,99,180,185],"more":[80],"than":[81],"800":[82],"lines.":[85],"Each":[86],"line":[88],"provides":[89],"gene":[90,134],"expression":[91],"values,":[92,204],"which":[93,205],"further":[95],"normalized":[96],"through":[97],"Z-transformation":[98],"each":[100],"gene.":[101],"However,":[102],"we":[103],"utilized":[104],"only":[105],"47":[106,151],"genes":[107,152],"our":[109],"research":[110],"due":[111],"limitations":[113],"computer":[115],"processing":[116],"speed":[117],"and":[118,144,167,249],"memory.":[119],"A":[120,148],"constructed":[126],"using":[127,158],"deep":[129,160],"learning":[130,161],"method":[131],"that":[132],"combines":[133],"expression,":[135],"Simplified":[137],"Molecular":[138],"Input":[139],"Line":[140],"Entry":[141],"System":[142],"(SMILES),":[143],"features.":[147],"panel":[149],"associated":[153],"processed":[157],"two":[159],"models:":[162],"Artificial":[163],"Neural":[164,169],"Network":[165,170],"(ANN)":[166],"Convolutional":[168],"(CNN).":[171],"This":[172,271],"approach":[173],"addresses":[174],"challenge":[176],"personalized":[178],"GBM,":[181],"offering":[182],"potential":[184,275],"improved":[186],"therapeutic":[187,208],"outcomes.":[188],"results":[190,237],"calculated":[196],"based":[197],"on":[198,267],"Half":[199],"Maximal":[200],"Inhibitory":[201],"Concentration":[202],"(IC50)":[203],"represent":[206],"effectiveness":[209,264],"inhibiting":[211],"growth":[213],"cells.":[216],"CNN":[217],"outperformed":[218],"ANN":[219],"significant":[222],"margin,":[223],"achieving":[224],"Root":[226],"Mean":[227,250],"Square":[228],"Error":[229,252],"(RMSE)":[230],"0.9822":[232],"compared":[233],"1.2127.":[235],"These":[236],"also":[239],"consistent":[240],"other":[242],"metrics,":[243],"including":[244],"Pearson":[245],"correlation,":[246,248],"Spearman":[247],"Absolute":[251],"(MAE).":[253],"According":[254],"study,":[257],"can":[260],"accurately":[261],"predict":[262,277],"drugs":[266],"genes.":[270],"study":[272],"has":[273],"during":[280],"procedures.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}