{"id":"https://openalex.org/W4404688265","doi":"https://doi.org/10.1109/access.2024.3503438","title":"A Computational Study of Efficient Combinations of FDA-approved drugs and dietary supplements in Endometrial Cancer","display_name":"A Computational Study of Efficient Combinations of FDA-approved drugs and dietary supplements in Endometrial Cancer","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4404688265","doi":"https://doi.org/10.1109/access.2024.3503438"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3503438","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3503438","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2024.3503438","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070343161","display_name":"Madhurima Mondal","orcid":"https://orcid.org/0009-0007-0255-7020"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhurima Mondal","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0009-0007-0255-7020","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053718192","display_name":"Aditya Lahiri","orcid":"https://orcid.org/0000-0001-9352-1312"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Lahiri","raw_affiliation_strings":["The Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021324799","display_name":"Haswanth Vundavilli","orcid":"https://orcid.org/0000-0002-3283-7732"},"institutions":[{"id":"https://openalex.org/I189109744","display_name":"Indian Institute of Technology Dhanbad","ror":"https://ror.org/013v3cc28","country_code":"IN","type":"education","lineage":["https://openalex.org/I189109744"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Haswanth Vundavilli","raw_affiliation_strings":["Department of Electrical Engineering, IIT (ISM), Dhanbad, India"],"raw_orcid":"https://orcid.org/0000-0002-3283-7732","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, IIT (ISM), Dhanbad, India","institution_ids":["https://openalex.org/I189109744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085328","display_name":"Giuseppe Del Priore","orcid":null},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Del Priore","raw_affiliation_strings":["Department of Obstetrics & Gynecology, Morehouse School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, Morehouse School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048860443","display_name":"N. Peter Reeves","orcid":"https://orcid.org/0000-0001-5021-7839"},"institutions":[{"id":"https://openalex.org/I4210155539","display_name":"Impaq International (United States)","ror":"https://ror.org/04kb0nk47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210155539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Peter Reeves","raw_affiliation_strings":["Sumaq Life LLC, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-5021-7839","affiliations":[{"raw_affiliation_string":"Sumaq Life LLC, Columbus, OH, USA","institution_ids":["https://openalex.org/I4210155539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045462352","display_name":"Aniruddha Datta","orcid":"https://orcid.org/0000-0003-1213-3807"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddha Datta","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-1213-3807","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.923,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.8705424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9435999989509583,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9435999989509583,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"Endometrial cancer","score":0.6640790104866028},{"id":"https://openalex.org/keywords/cancer-drugs","display_name":"Cancer drugs","score":0.5932689905166626},{"id":"https://openalex.org/keywords/dietary-supplement","display_name":"Dietary supplement","score":0.4916537404060364},{"id":"https://openalex.org/keywords/approved-drug","display_name":"Approved drug","score":0.4781402349472046},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.427909791469574},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.42677342891693115},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4174528419971466},{"id":"https://openalex.org/keywords/drug-approval","display_name":"Drug approval","score":0.4139992594718933},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3671920895576477},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2666158676147461},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1650310754776001},{"id":"https://openalex.org/keywords/food-science","display_name":"Food science","score":0.08366358280181885}],"concepts":[{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6640790104866028},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.5932689905166626},{"id":"https://openalex.org/C3018363719","wikidata":"https://www.wikidata.org/wiki/Q645858","display_name":"Dietary supplement","level":2,"score":0.4916537404060364},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.4781402349472046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.427909791469574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42677342891693115},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4174528419971466},{"id":"https://openalex.org/C2992293740","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Drug approval","level":3,"score":0.4139992594718933},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3671920895576477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2666158676147461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1650310754776001},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.08366358280181885}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2024.3503438","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3503438","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:45e6dcb1255440b9a8b48aab6d088d6b","is_oa":true,"landing_page_url":"https://doaj.org/article/45e6dcb1255440b9a8b48aab6d088d6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 12, Pp 190746-190759 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3503438","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3503438","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6100000143051147,"display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G6408125998","display_name":"Cancer Therapeutics through Theory and Experiment: From Cell Lines to Canine Tumors Grown on the Back of Mice","funder_award_id":"1917166","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W82591098","https://openalex.org/W302807093","https://openalex.org/W1557079413","https://openalex.org/W1578104218","https://openalex.org/W1600339875","https://openalex.org/W1963892864","https://openalex.org/W1971224531","https://openalex.org/W1991333402","https://openalex.org/W1991381877","https://openalex.org/W2003201884","https://openalex.org/W2010018906","https://openalex.org/W2028521648","https://openalex.org/W2032695660","https://openalex.org/W2033591223","https://openalex.org/W2036058659","https://openalex.org/W2036568936","https://openalex.org/W2036804520","https://openalex.org/W2065879491","https://openalex.org/W2072004456","https://openalex.org/W2083407667","https://openalex.org/W2099288089","https://openalex.org/W2100794488","https://openalex.org/W2101217308","https://openalex.org/W2109870736","https://openalex.org/W2110230208","https://openalex.org/W2113196089","https://openalex.org/W2119220491","https://openalex.org/W2128752747","https://openalex.org/W2142576336","https://openalex.org/W2142948690","https://openalex.org/W2169784061","https://openalex.org/W2171714609","https://openalex.org/W2173189766","https://openalex.org/W2279056171","https://openalex.org/W2560866543","https://openalex.org/W2600452401","https://openalex.org/W2601621997","https://openalex.org/W2741997789","https://openalex.org/W2886987811","https://openalex.org/W2892837103","https://openalex.org/W2900863907","https://openalex.org/W2910165589","https://openalex.org/W2938279941","https://openalex.org/W2939566402","https://openalex.org/W2962586713","https://openalex.org/W2964572246","https://openalex.org/W2970260001","https://openalex.org/W2982051641","https://openalex.org/W2988352835","https://openalex.org/W3011919019","https://openalex.org/W3013296409","https://openalex.org/W3014495183","https://openalex.org/W3015223754","https://openalex.org/W3015698159","https://openalex.org/W3015784228","https://openalex.org/W3038416910","https://openalex.org/W3089709043","https://openalex.org/W3090386083","https://openalex.org/W3091890345","https://openalex.org/W3094525436","https://openalex.org/W3097490979","https://openalex.org/W3131777956","https://openalex.org/W3139023757","https://openalex.org/W3163121110","https://openalex.org/W3165264111","https://openalex.org/W3180375767","https://openalex.org/W3186348651","https://openalex.org/W3196548911","https://openalex.org/W4205306227","https://openalex.org/W4225252363","https://openalex.org/W4232787766","https://openalex.org/W4289134397","https://openalex.org/W4296312326","https://openalex.org/W4306366824","https://openalex.org/W4308183542","https://openalex.org/W4311587288","https://openalex.org/W4312113516","https://openalex.org/W4315754639","https://openalex.org/W4319160026","https://openalex.org/W4323348035","https://openalex.org/W4379534644","https://openalex.org/W4380049961","https://openalex.org/W4383721040","https://openalex.org/W4391924203"],"related_works":["https://openalex.org/W2989471602","https://openalex.org/W3190397922","https://openalex.org/W2323335855","https://openalex.org/W2014542943","https://openalex.org/W2742865635","https://openalex.org/W3136094499","https://openalex.org/W2130544284","https://openalex.org/W2756717034","https://openalex.org/W1975736964","https://openalex.org/W2121157943"],"abstract_inverted_index":{"Endometrial":[0],"cancer":[1,20,34],"(EC)":[2],"develops":[3],"in":[4,9,21,71,123,181,249],"the":[5,22,64,132,140,172,233],"uterine":[6,19],"lining,":[7],"and":[8,56,66,150,178,215],"2024,":[10],"there":[11],"will":[12],"be":[13,160],"approximately":[14],"67,880":[15],"reported":[16],"cases":[17],"of":[18,26,109,134,142,175],"USA,":[23],"with":[24,105,206,242],"90%":[25],"them":[27],"being":[28],"EC.":[29,183,250],"Many":[30],"unfit":[31],"or":[32,48,111],"elderly":[33],"patients":[35,99],"are":[36,81,87,240],"unable":[37],"to":[38,159,169,191,226],"undergo":[39],"standard":[40],"treatments":[41],"for":[42,83,98,164,204,235],"EC":[43,110],"such":[44,52,146,193],"as":[45,127,147],"surgery,":[46],"chemotherapy,":[47],"radiation":[49],"therapy.":[50],"For":[51],"patients,":[53],"targeted":[54,176],"therapies":[55,97,177],"immunotherapy":[57,203,246],"drugs":[58],"that":[59,199],"have":[60,67],"received":[61],"approval":[62],"from":[63,224],"FDA":[65],"demonstrated":[68],"significant":[69],"efficacy":[70],"treating":[72,182],"EC,":[73,165],"offer":[74],"a":[75,90,106,128,161,187,243],"viable":[76],"alternative.":[77],"Dietary":[78],"supplements,":[79],"which":[80],"known":[82],"their":[84,116,124],"lower":[85],"toxicity,":[86],"increasingly":[88],"becoming":[89],"complementary":[91],"treatment":[92,163,247],"option,":[93],"alongside":[94],"conventional":[95],"primary":[96],"battling":[100],"many":[101],"cancers.":[102],"Additionally,":[103],"individuals":[104],"family":[107],"history":[108],"those":[112],"focused":[113],"on":[114],"maintaining":[115],"overall":[117],"well-being":[118],"often":[119],"include":[120],"these":[121],"supplements":[122,137,180,208,239],"daily":[125],"diet":[126],"proactive":[129],"measure.":[130],"However,":[131],"consumption":[133],"random":[135],"inefficient":[136],"may":[138],"elevate":[139],"risk":[141],"other":[143],"health":[144],"issues,":[145],"headaches,":[148],"nausea,":[149],"fatigue.":[151],"Since":[152],"combination":[153],"therapy":[154],"has":[155],"been":[156],"already":[157],"shown":[158],"successful":[162],"it":[166],"makes":[167],"sense":[168],"consider":[170],"finding":[171],"optimal":[173],"combinations":[174],"dietary":[179,207],"This":[184,231],"paper":[185],"uses":[186],"Boolean":[188],"Network":[189],"approach":[190],"find":[192],"combinations.":[194,230],"Our":[195],"computational":[196],"analysis":[197],"predicts":[198],"combining":[200],"Pembrolizumab":[201],"(FDA-approved":[202],"EC)":[205],"like":[209],"Epigallocatechin":[210],"Gallate":[211],"(EGCG),":[212],"Melatonin,":[213],"Curcumin,":[214],"Baicalein":[216],"significantly":[217],"enhances":[218],"its":[219],"efficacy,":[220],"showing":[221],"improvements":[222],"ranging":[223],"71.22%":[225],"99.99%":[227],"across":[228],"different":[229],"demonstrates":[232],"potential":[234],"synergistic":[236],"effects":[237],"when":[238],"combined":[241],"commonly":[244],"used":[245],"(Pembrolizumab)":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}