{"id":"https://openalex.org/W4403976991","doi":"https://doi.org/10.1109/access.2024.3489798","title":"A Systematic Review of Quantitative MRI Brain Analysis Studies in Multiple Sclerosis Disease","display_name":"A Systematic Review of Quantitative MRI Brain Analysis Studies in Multiple Sclerosis Disease","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403976991","doi":"https://doi.org/10.1109/access.2024.3489798"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3489798","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3489798","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2024.3489798","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071493995","display_name":"Andria Nicolaou","orcid":"https://orcid.org/0000-0002-4863-6505"},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Andria Nicolaou","raw_affiliation_strings":["Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055191156","display_name":"Christos P. Loizou","orcid":"https://orcid.org/0000-0003-1247-8573"},"institutions":[{"id":"https://openalex.org/I163151358","display_name":"Cyprus University of Technology","ror":"https://ror.org/05qt8tf94","country_code":"CY","type":"education","lineage":["https://openalex.org/I163151358"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Christos P. Loizou","raw_affiliation_strings":["Department of Electrical Engineering, Computer Engineering and Informatics, Cyprus University of Technology, Limassol, Cyprus"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Computer Engineering and Informatics, Cyprus University of Technology, Limassol, Cyprus","institution_ids":["https://openalex.org/I163151358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004010381","display_name":"Marios Pantzaris","orcid":"https://orcid.org/0000-0003-2937-384X"},"institutions":[{"id":"https://openalex.org/I55905543","display_name":"Cyprus Institute of Neurology and Genetics","ror":"https://ror.org/01ggsp920","country_code":"CY","type":"nonprofit","lineage":["https://openalex.org/I55905543"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Marios Pantzaris","raw_affiliation_strings":["The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus"],"affiliations":[{"raw_affiliation_string":"The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus","institution_ids":["https://openalex.org/I55905543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079839426","display_name":"Constantinos S. Pattichis","orcid":null},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Constantinos S. Pattichis","raw_affiliation_strings":["Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071493995"],"corresponding_institution_ids":["https://openalex.org/I34771391"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.2476,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58198009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"12","issue":null,"first_page":"162359","last_page":"162391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.766700029373169,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.766700029373169,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5604147911071777},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.50567626953125},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4936753213405609},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3645780384540558},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.27276456356048584}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5604147911071777},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.50567626953125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4936753213405609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3645780384540558},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27276456356048584},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/access.2024.3489798","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3489798","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1c2b356f002c49f999ccba0f13ec3281","is_oa":true,"landing_page_url":"https://doaj.org/article/1c2b356f002c49f999ccba0f13ec3281","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 12, Pp 162359-162391 (2024)","raw_type":"article"},{"id":"pmh:oai:zenodo.org:15664830","is_oa":true,"landing_page_url":"https://doi.org/10.1109/ACCESS.2024.3489798","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3489798","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3489798","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313981","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":154,"referenced_works":["https://openalex.org/W1787224781","https://openalex.org/W1901129140","https://openalex.org/W1971453924","https://openalex.org/W1973457617","https://openalex.org/W1986766905","https://openalex.org/W1997951332","https://openalex.org/W2007472100","https://openalex.org/W2019090719","https://openalex.org/W2021204548","https://openalex.org/W2034309449","https://openalex.org/W2044465660","https://openalex.org/W2047440597","https://openalex.org/W2063948766","https://openalex.org/W2096609500","https://openalex.org/W2102848905","https://openalex.org/W2105490558","https://openalex.org/W2112165124","https://openalex.org/W2112360435","https://openalex.org/W2117395697","https://openalex.org/W2117530999","https://openalex.org/W2118090476","https://openalex.org/W2119449853","https://openalex.org/W2137249533","https://openalex.org/W2147555557","https://openalex.org/W2152595235","https://openalex.org/W2167003500","https://openalex.org/W2171765626","https://openalex.org/W2175642482","https://openalex.org/W2325852610","https://openalex.org/W2342591535","https://openalex.org/W2417429787","https://openalex.org/W2471406153","https://openalex.org/W2553647727","https://openalex.org/W2575552683","https://openalex.org/W2586165015","https://openalex.org/W2589409328","https://openalex.org/W2618530766","https://openalex.org/W2620156419","https://openalex.org/W2752465009","https://openalex.org/W2765961644","https://openalex.org/W2767128594","https://openalex.org/W2768214891","https://openalex.org/W2777074421","https://openalex.org/W2787687030","https://openalex.org/W2789235061","https://openalex.org/W2792641128","https://openalex.org/W2794703302","https://openalex.org/W2806729167","https://openalex.org/W2809848353","https://openalex.org/W2822024738","https://openalex.org/W2889392446","https://openalex.org/W2895614609","https://openalex.org/W2896014118","https://openalex.org/W2897994977","https://openalex.org/W2899547849","https://openalex.org/W2900299818","https://openalex.org/W2902300896","https://openalex.org/W2907648650","https://openalex.org/W2943358380","https://openalex.org/W2949143034","https://openalex.org/W2951680115","https://openalex.org/W2951901024","https://openalex.org/W2963052998","https://openalex.org/W2963446712","https://openalex.org/W2967750615","https://openalex.org/W2970488713","https://openalex.org/W2971561076","https://openalex.org/W2971685841","https://openalex.org/W2977883299","https://openalex.org/W2980956888","https://openalex.org/W2986910815","https://openalex.org/W2987112463","https://openalex.org/W2988064907","https://openalex.org/W2994834352","https://openalex.org/W2995209110","https://openalex.org/W2997337740","https://openalex.org/W3005146403","https://openalex.org/W3014974815","https://openalex.org/W3017200700","https://openalex.org/W3026705055","https://openalex.org/W3027069075","https://openalex.org/W3027358948","https://openalex.org/W3034198839","https://openalex.org/W3036319923","https://openalex.org/W3038972077","https://openalex.org/W3042066439","https://openalex.org/W3043135758","https://openalex.org/W3043604393","https://openalex.org/W3048181943","https://openalex.org/W3081739608","https://openalex.org/W3083138635","https://openalex.org/W3088813743","https://openalex.org/W3090140268","https://openalex.org/W3093905802","https://openalex.org/W3094574213","https://openalex.org/W3101062761","https://openalex.org/W3101769997","https://openalex.org/W3112701542","https://openalex.org/W3113143857","https://openalex.org/W3119458123","https://openalex.org/W3123893780","https://openalex.org/W3137349040","https://openalex.org/W3138277089","https://openalex.org/W3156196068","https://openalex.org/W3159675419","https://openalex.org/W3189411510","https://openalex.org/W3191859633","https://openalex.org/W3201772714","https://openalex.org/W3204149255","https://openalex.org/W3210428796","https://openalex.org/W3210752342","https://openalex.org/W3211288104","https://openalex.org/W3216903619","https://openalex.org/W4205882540","https://openalex.org/W4205923499","https://openalex.org/W4206292621","https://openalex.org/W4214499495","https://openalex.org/W4220671531","https://openalex.org/W4229011562","https://openalex.org/W4241595412","https://openalex.org/W4284992171","https://openalex.org/W4285078956","https://openalex.org/W4285210889","https://openalex.org/W4286433003","https://openalex.org/W4290052354","https://openalex.org/W4291149789","https://openalex.org/W4307165495","https://openalex.org/W4310693661","https://openalex.org/W4312084109","https://openalex.org/W4317933288","https://openalex.org/W4321472461","https://openalex.org/W4322629576","https://openalex.org/W4324128823","https://openalex.org/W4360770824","https://openalex.org/W4376126519","https://openalex.org/W4377023536","https://openalex.org/W4377565370","https://openalex.org/W4383219060","https://openalex.org/W4385774886","https://openalex.org/W4385777598","https://openalex.org/W4385837228","https://openalex.org/W4386870052","https://openalex.org/W4387110180","https://openalex.org/W4388674337","https://openalex.org/W4389461461","https://openalex.org/W6637373629","https://openalex.org/W6637782675","https://openalex.org/W6685133223","https://openalex.org/W6735355855","https://openalex.org/W6736518430","https://openalex.org/W6738409699","https://openalex.org/W6750046652","https://openalex.org/W6849546605","https://openalex.org/W6855448957"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"The":[0],"heterogeneity":[1],"of":[2,24,30,65,127,160],"Multiple":[3],"Sclerosis":[4],"(MS)":[5],"is":[6,146],"a":[7,62],"challenge":[8],"for":[9],"the":[10,20,26,119],"disease":[11,72,129,161],"diagnosis":[12],"and":[13,22,28,55,79,93,113,121,135,152,158],"its":[14],"evolution.":[15,162],"In":[16],"order":[17],"to":[18,46,60,70,117],"monitor":[19],"treatment":[21],"progression":[23],"MS,":[25],"segmentation":[27,84],"analysis":[29,103],"brain":[31,66],"magnetic":[32],"resonance":[33],"imaging":[34],"(MRI)":[35],"lesions":[36],"may":[37,43],"offer":[38,133],"quantitative":[39],"evaluation":[40],"metrics":[41],"that":[42],"be":[44],"used":[45],"compare":[47],"images":[48],"across":[49],"various":[50],"regions,":[51],"patients,":[52],"time":[53],"points,":[54],"institutions.":[56],"This":[57],"study":[58],"targets":[59],"provide":[61],"comprehensive":[63],"review":[64],"MRI":[67],"studies":[68],"related":[69],"MS":[71,128],"focusing":[73],"on":[74,105],"lesion":[75],"segmentation,":[76],"feature":[77,106],"extraction,":[78],"Computer-Aided":[80],"Diagnosis":[81],"(CAD).":[82],"Image":[83,102],"methods":[85,108],"were":[86],"categorized":[87],"regarding":[88],"their":[89,98],"supervision":[90],"(i.e.,":[91],"supervised,":[92],"unsupervised),":[94],"as":[95,97,110,130,132],"well":[96,131],"deep":[99],"learning":[100],"capability.":[101],"focused":[104],"extraction":[107],"such":[109],"texture,":[111],"structure,":[112],"image":[114],"characterization.":[115],"Furthermore,":[116],"address":[118],"challenges":[120],"future":[122],"directions,":[123],"enable":[124],"better":[125],"management":[126],"personalized":[134],"precision":[136],"medicine":[137],"services":[138],"in":[139],"clinical":[140],"praxis,":[141],"an":[142],"integrated":[143],"CAD":[144],"framework":[145],"proposed":[147],"encompassing":[148],"3D":[149],"reconstruction,":[150],"registration":[151],"visualization,":[153],"explainable":[154],"artificial":[155],"intelligence":[156],"(AI)":[157],"assessment":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}