{"id":"https://openalex.org/W4399039561","doi":"https://doi.org/10.1109/access.2024.3406030","title":"Robust Control for Cancer Chemotherapy Through Time Delayed Estimation Philosophy","display_name":"Robust Control for Cancer Chemotherapy Through Time Delayed Estimation Philosophy","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4399039561","doi":"https://doi.org/10.1109/access.2024.3406030"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3406030","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3406030","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10539975.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10539975.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017212982","display_name":"Rajasree Sarkar","orcid":"https://orcid.org/0000-0002-8276-0235"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajasree Sarkar","raw_affiliation_strings":["Mechanical Engineering Department, University of Minnesota Twin Cities, Minneapolis, MN, USA","Mechanical Engineering Department, University of Minnesota, Twin Cities, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical Engineering Department, University of Minnesota Twin Cities, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I4210101327"]},{"raw_affiliation_string":"Mechanical Engineering Department, University of Minnesota, Twin Cities, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210101327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059667465","display_name":"Oumaima Saidani","orcid":"https://orcid.org/0000-0001-9520-3174"},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Oumaima Saidani","raw_affiliation_strings":["Department of Information Systems, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box, 84428, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-9520-3174","affiliations":[{"raw_affiliation_string":"Department of Information Systems, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box, 84428, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071032802","display_name":"Latifah Almuqren","orcid":null},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Latifah Almuqren","raw_affiliation_strings":["Department of Information Systems, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box, 84428, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-6815-926X","affiliations":[{"raw_affiliation_string":"Department of Information Systems, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box, 84428, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034681226","display_name":"Syed Muhammad Amrr","orcid":"https://orcid.org/0000-0001-5084-5472"},"institutions":[{"id":"https://openalex.org/I134085113","display_name":"King Fahd University of Petroleum and Minerals","ror":"https://ror.org/03yez3163","country_code":"SA","type":"education","lineage":["https://openalex.org/I134085113"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Syed Muhammad Amrr","raw_affiliation_strings":["Control and Instrumentation Engineering Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia","Interdisciplinary Research Center for Sustainability Energy Systems (IRC-SES), KFUPM, Dhahran, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-5084-5472","affiliations":[{"raw_affiliation_string":"Control and Instrumentation Engineering Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia","institution_ids":["https://openalex.org/I134085113"]},{"raw_affiliation_string":"Interdisciplinary Research Center for Sustainability Energy Systems (IRC-SES), KFUPM, Dhahran, Saudi Arabia","institution_ids":["https://openalex.org/I134085113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044599573","display_name":"Arunava Banerjee","orcid":"https://orcid.org/0000-0002-6792-4019"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arunava Banerjee","raw_affiliation_strings":["Mechanical Engineering Department, University of Minnesota Twin Cities, Minneapolis, MN, USA","Mechanical Engineering Department, University of Minnesota, Twin Cities, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-6792-4019","affiliations":[{"raw_affiliation_string":"Mechanical Engineering Department, University of Minnesota Twin Cities, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I4210101327"]},{"raw_affiliation_string":"Mechanical Engineering Department, University of Minnesota, Twin Cities, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210101327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044748360","display_name":"Abdelaziz Salah Saidi","orcid":"https://orcid.org/0000-0003-1725-2418"},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]},{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA","TN"],"is_corresponding":false,"raw_author_name":"Abdelaziz Salah Saidi","raw_affiliation_strings":["Laboratoire des Systèmes Électriques, École Nationale d’Ingénieurs de Tunis, Université de Tunis El Manar, Tunis, Tunisia","Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-1725-2418","affiliations":[{"raw_affiliation_string":"Laboratoire des Systèmes Électriques, École Nationale d’Ingénieurs de Tunis, Université de Tunis El Manar, Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]},{"raw_affiliation_string":"Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.8837,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68465514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"77171","last_page":"77180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9753000140190125,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7187443971633911},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.6377784013748169},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5729768872261047},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4906577169895172},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.42761939764022827},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.2783711552619934},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25060319900512695},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.11636292934417725}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7187443971633911},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.6377784013748169},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5729768872261047},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4906577169895172},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.42761939764022827},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.2783711552619934},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25060319900512695},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11636292934417725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2024.3406030","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3406030","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10539975.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8179232bf19e4bd1b441bb8203f01f02","is_oa":true,"landing_page_url":"https://doaj.org/article/8179232bf19e4bd1b441bb8203f01f02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 12, Pp 77171-77180 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3406030","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3406030","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10539975.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4399039561.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W26381887","https://openalex.org/W1955880755","https://openalex.org/W1997551282","https://openalex.org/W2003383420","https://openalex.org/W2013304036","https://openalex.org/W2024131269","https://openalex.org/W2032860423","https://openalex.org/W2034852211","https://openalex.org/W2056572610","https://openalex.org/W2060085351","https://openalex.org/W2081116284","https://openalex.org/W2082343402","https://openalex.org/W2083937970","https://openalex.org/W2087600569","https://openalex.org/W2090180109","https://openalex.org/W2111509327","https://openalex.org/W2163383042","https://openalex.org/W2167054844","https://openalex.org/W2604368146","https://openalex.org/W2691147593","https://openalex.org/W2775240467","https://openalex.org/W2889679669","https://openalex.org/W2906373196","https://openalex.org/W2927876659","https://openalex.org/W2937356899","https://openalex.org/W2939168811","https://openalex.org/W2998043946","https://openalex.org/W3039541015","https://openalex.org/W3040832055","https://openalex.org/W3090667595","https://openalex.org/W3118615374","https://openalex.org/W3124659242","https://openalex.org/W3187419526","https://openalex.org/W3196549316","https://openalex.org/W4200486584","https://openalex.org/W4212929145","https://openalex.org/W4285728895","https://openalex.org/W4311863228","https://openalex.org/W4363650959","https://openalex.org/W4385488339","https://openalex.org/W4390591173","https://openalex.org/W6601137026","https://openalex.org/W6601297175","https://openalex.org/W6717190520"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4388311650","https://openalex.org/W5922282","https://openalex.org/W1974056099","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4245343541"],"abstract_inverted_index":{"Chemotherapy,":[0],"a":[1,48,79],"vital":[2],"cancer":[3,13],"treatment,":[4],"operates":[5],"by":[6,102],"delivering":[7],"drugs":[8,41],"to":[9,34,57],"target":[10],"and":[11,37,70,85,96,107,113],"eliminate":[12],"cells":[14],"in":[15,64],"the":[16,22,27,30,35,40,43,59,76,91,97,104,110,132,139,150,153],"patient":[17],"body.":[18],"Mathematical":[19],"models":[20],"like":[21],"log-kill,":[23],"Norton-Simon,":[24],"andEmaxhypotheses":[25],"describe":[26],"growth/shrinking":[28],"of":[29,39,62,82,109,131,152],"cancerous":[31],"tumor":[32,65],"due":[33],"interaction":[36],"administration":[38],"with":[42,146],"tumor.":[44],"This":[45],"paper":[46],"proposes":[47],"robust":[49],"control":[50,92,114],"approach":[51],"based":[52,137],"on":[53,78,122,138],"artificial":[54],"time-delayed":[55],"theory":[56],"track":[58],"desired":[60],"rate":[61],"change":[63],"volume":[66],"under":[67],"model":[68],"uncertainties":[69],"disturbances.":[71],"The":[72,128],"proposed":[73,133,154],"algorithm":[74],"relaxes":[75],"assumption":[77],"priori":[80],"knowledge":[81],"disturbance":[83,99],"bound":[84],"its":[86],"derivative.":[87],"Unlike":[88],"traditional":[89],"methods,":[90],"structure":[93],"is":[94,100,118,135],"simple,":[95],"total":[98],"estimated":[101],"analyzing":[103],"previous":[105],"input":[106],"output":[108],"feedback":[111],"state":[112],"variables.":[115],"Thus,":[116],"robustness":[117],"ensured":[119],"without":[120],"relying":[121],"high-frequency":[123],"switching":[124],"or":[125],"high":[126],"gain.":[127],"stability":[129],"analysis":[130,148],"scheme":[134],"investigated":[136],"Lyapunov":[140],"theory.":[141],"Moreover,":[142],"extensive":[143],"simulation":[144],"results":[145],"comparative":[147],"affirm":[149],"efficacy":[151],"approach.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}