{"id":"https://openalex.org/W4396766402","doi":"https://doi.org/10.1109/access.2024.3399711","title":"A Retina-Inspired Computational Model for Stimulation Efficacy Characterization and Implementation Optimization of Implantable Optogenetic Epi-Retinal Neuro- Stimulators","display_name":"A Retina-Inspired Computational Model for Stimulation Efficacy Characterization and Implementation Optimization of Implantable Optogenetic Epi-Retinal Neuro- Stimulators","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4396766402","doi":"https://doi.org/10.1109/access.2024.3399711"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3399711","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3399711","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10528280.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10528280.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018041628","display_name":"Tayebeh Yousefi","orcid":"https://orcid.org/0000-0002-0600-8957"},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tayebeh Yousefi","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0600-8957","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada","institution_ids":["https://openalex.org/I192455969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062337024","display_name":"Hossein Kassiri","orcid":"https://orcid.org/0000-0002-8220-1986"},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hossein Kassiri","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8220-1986","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada","institution_ids":["https://openalex.org/I192455969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018041628"],"corresponding_institution_ids":["https://openalex.org/I192455969"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.5048,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60911923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"12","issue":null,"first_page":"67233","last_page":"67245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11992","display_name":"CCD and CMOS Imaging Sensors","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optogenetics","display_name":"Optogenetics","score":0.870868980884552},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6685451865196228},{"id":"https://openalex.org/keywords/visual-prosthesis","display_name":"Visual prosthesis","score":0.6658138632774353},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.627058207988739},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.6196688413619995},{"id":"https://openalex.org/keywords/retinal-implant","display_name":"Retinal implant","score":0.5499920845031738},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5309191346168518},{"id":"https://openalex.org/keywords/visual-perception","display_name":"Visual perception","score":0.5071580410003662},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.43509408831596375},{"id":"https://openalex.org/keywords/perception","display_name":"Perception","score":0.37607696652412415},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.37442833185195923},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3370228409767151},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.11687567830085754},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11030572652816772},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10717055201530457}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.870868980884552},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6685451865196228},{"id":"https://openalex.org/C2778560042","wikidata":"https://www.wikidata.org/wiki/Q540043","display_name":"Visual prosthesis","level":3,"score":0.6658138632774353},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.627058207988739},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6196688413619995},{"id":"https://openalex.org/C158383150","wikidata":"https://www.wikidata.org/wiki/Q3149439","display_name":"Retinal implant","level":3,"score":0.5499920845031738},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5309191346168518},{"id":"https://openalex.org/C178253425","wikidata":"https://www.wikidata.org/wiki/Q162668","display_name":"Visual perception","level":3,"score":0.5071580410003662},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43509408831596375},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.37607696652412415},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37442833185195923},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3370228409767151},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.11687567830085754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11030572652816772},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10717055201530457},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2024.3399711","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3399711","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10528280.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4aa3deeb9c3249429c06e5a64305f863","is_oa":true,"landing_page_url":"https://doaj.org/article/4aa3deeb9c3249429c06e5a64305f863","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 12, Pp 67233-67245 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3399711","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3399711","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/10528280.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310709","display_name":"CMC Microsystems","ror":"https://ror.org/03k70ea39"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396766402.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W36411100","https://openalex.org/W1972160853","https://openalex.org/W1978023046","https://openalex.org/W1985304131","https://openalex.org/W1995001599","https://openalex.org/W1997184856","https://openalex.org/W2025128626","https://openalex.org/W2058082904","https://openalex.org/W2069519142","https://openalex.org/W2090583902","https://openalex.org/W2104998551","https://openalex.org/W2106937721","https://openalex.org/W2115295370","https://openalex.org/W2131773286","https://openalex.org/W2133665775","https://openalex.org/W2135335251","https://openalex.org/W2150818788","https://openalex.org/W2155668458","https://openalex.org/W2155972301","https://openalex.org/W2160226180","https://openalex.org/W2162937730","https://openalex.org/W2167392460","https://openalex.org/W2401981424","https://openalex.org/W2509583655","https://openalex.org/W2584123617","https://openalex.org/W2620368413","https://openalex.org/W2916601208","https://openalex.org/W2950242659","https://openalex.org/W2952153146","https://openalex.org/W2952502476","https://openalex.org/W3008728252","https://openalex.org/W3016004439","https://openalex.org/W3018821012","https://openalex.org/W3020647924","https://openalex.org/W3035540527","https://openalex.org/W3088863608","https://openalex.org/W3094054138","https://openalex.org/W3097775566","https://openalex.org/W3103537415","https://openalex.org/W3137926359","https://openalex.org/W4200378755","https://openalex.org/W4211089624","https://openalex.org/W6601465935","https://openalex.org/W6686604056"],"related_works":["https://openalex.org/W2985787306","https://openalex.org/W1983632939","https://openalex.org/W4388938748","https://openalex.org/W2027547973","https://openalex.org/W2119203151","https://openalex.org/W2476154117","https://openalex.org/W2568687041","https://openalex.org/W2189099429","https://openalex.org/W2113792828","https://openalex.org/W2982939032"],"abstract_inverted_index":{"In":[0,210],"this":[1,109],"paper,":[2],"a":[3,28,222],"biologically-informed":[4],"computational":[5],"framework":[6],"is":[7,34],"developed":[8,32],"to":[9,14,140,179,249],"model":[10,33,74,175],"the":[11,16,46,54,59,65,78,90,103,106,120,129,132,141,170,184,203,206,213,235],"efficacy":[12,104,252],"and":[13,63,75,89,114,131,181,195,198,253],"optimize":[15],"implementation":[17],"of":[18,36,58,80,105,119,144,186,205,225,244],"an":[19,245],"implantable":[20,246],"epi-retinal":[21],"prosthesis":[22],"that":[23,138,161],"performs":[24],"optogenetic":[25,51,145,247],"stimulation":[26,82],"through":[27,50],"\u03bcLED":[29,91],"array.":[30],"The":[31,174],"capable":[35],"translating":[37],"visual":[38,68,126,133,152,164,208],"stimulus":[39,134],"inputs":[40],"into":[41],"corresponding":[42],"signals":[43],"evoked":[44],"in":[45,117,128,229],"transfected":[47],"retinal":[48,61],"cells":[49],"stimulation,":[52,146,197],"calculating":[53],"subsequent":[55],"neuronal":[56],"activities":[57],"following":[60],"layers,":[62],"estimating":[64],"resulted":[66,163],"brain\u2019s":[67],"perception.":[69,209],"As":[70],"such,":[71],"it":[72,147],"can":[73,148],"quantitatively":[76,182],"analyze":[77,183],"impact":[79,185],"optical":[81,113],"parameters":[83,187,243],"(intensity,":[84],"frequency,":[85],"directivity,":[86],"wavelength,":[87],"etc.)":[88,101],"array\u2019s":[92],"physical":[93],"specifications":[94],"(array":[95],"size,":[96],"density,":[97],"pitch,":[98],"implantation":[99,190],"location,":[100,191],"on":[102,202],"stimulation.":[107,157],"Using":[108],"model,":[110],"we":[111,232],"compared":[112],"electrical":[115,156],"stimulations":[116],"terms":[118],"structural":[121],"similarity":[122],"between":[123],"their":[124],"induced":[125],"perception":[127,153,165],"brain":[130],"input.":[135],"We":[136,158],"showed":[137,160],"thanks":[139],"cell-type":[142],"specificity":[143],"induce":[149],"more":[150],"relevant":[151],"qualities":[154],"than":[155],"also":[159,177],"its":[162],"substantially":[166],"improves":[167],"with":[168],"scaling":[169],"stimulator\u2019s":[171],"array":[172],"size.":[173],"was":[176],"used":[178,239],"qualitatively":[180],"such":[188],"as":[189],"light":[192],"intensity,":[193],"single-":[194],"dual-wavelength":[196],"illumination":[199],"divergence":[200],"angle":[201],"quality":[204],"optical-stimulation-induced":[207],"each":[211,230],"case,":[212,231],"simulation":[214],"results":[215,236],"were":[216],"followed":[217],"by":[218],"our":[219],"interpretation":[220],"from":[221],"biological":[223],"point":[224],"view.":[226],"More":[227],"importantly,":[228],"discussed":[233],"how":[234],"could":[237],"be":[238],"for":[240],"optimizing":[241],"different":[242],"stimulator":[248],"achieve":[250],"maximum":[251],"energy":[254],"efficiency.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
