{"id":"https://openalex.org/W4395661560","doi":"https://doi.org/10.1109/access.2024.3393984","title":"Transcutaneous Auricular Vagus Nerve Stimulation Can Alter Autonomic Function and Induce an Antiepileptic Effect in Pentylenetetrazol- Induced Seizures in Rats","display_name":"Transcutaneous Auricular Vagus Nerve Stimulation Can Alter Autonomic Function and Induce an Antiepileptic Effect in Pentylenetetrazol- Induced Seizures in Rats","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4395661560","doi":"https://doi.org/10.1109/access.2024.3393984"},"language":"en","primary_location":{"id":"doi:10.1109/access.2024.3393984","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3393984","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2024.3393984","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102733398","display_name":"Eun-Mi Choi","orcid":"https://orcid.org/0009-0003-3816-8669"},"institutions":[{"id":"https://openalex.org/I24541011","display_name":"Soonchunhyang University","ror":"https://ror.org/03qjsrb10","country_code":"KR","type":"education","lineage":["https://openalex.org/I24541011"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunmi Choi","raw_affiliation_strings":["Department of Biomedical Engineering, Soonchunhyang University, Asan, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0003-3816-8669","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Soonchunhyang University, Asan, Republic of Korea","institution_ids":["https://openalex.org/I24541011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657828","display_name":"Tae-Kyung Kim","orcid":"https://orcid.org/0000-0002-4233-8574"},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taekyung Kim","raw_affiliation_strings":["Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4233-8574","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038717839","display_name":"Sungjun Hong","orcid":"https://orcid.org/0000-0003-2797-238X"},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Jun Hong","raw_affiliation_strings":["Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066846547","display_name":"Taewoo Kim","orcid":"https://orcid.org/0000-0002-1474-8808"},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taewoo Kim","raw_affiliation_strings":["Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1474-8808","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082783833","display_name":"Minhee Kang","orcid":"https://orcid.org/0000-0003-0330-7828"},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minhee Kang","raw_affiliation_strings":["Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033461778","display_name":"Young\u2010Min Shon","orcid":"https://orcid.org/0000-0001-5171-1695"},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Min Shon","raw_affiliation_strings":["Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5171-1695","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Research Center, Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084821259","display_name":"Eunkyoung Park","orcid":"https://orcid.org/0000-0001-7700-0250"},"institutions":[{"id":"https://openalex.org/I24541011","display_name":"Soonchunhyang University","ror":"https://ror.org/03qjsrb10","country_code":"KR","type":"education","lineage":["https://openalex.org/I24541011"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunkyoung Park","raw_affiliation_strings":["Department of Biomedical Engineering, Soonchunhyang University, Asan, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7700-0250","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Soonchunhyang University, Asan, Republic of Korea","institution_ids":["https://openalex.org/I24541011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.215,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50752698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"12","issue":null,"first_page":"60112","last_page":"60122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.9033469557762146},{"id":"https://openalex.org/keywords/pentylenetetrazol","display_name":"Pentylenetetrazol","score":0.8641065955162048},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.5727528929710388},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.566983699798584},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5640919208526611},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.5602392554283142},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.40062639117240906},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3642749786376953},{"id":"https://openalex.org/keywords/anticonvulsant","display_name":"Anticonvulsant","score":0.151841402053833},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14857131242752075},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.08220085501670837}],"concepts":[{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.9033469557762146},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.8641065955162048},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.5727528929710388},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.566983699798584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5640919208526611},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5602392554283142},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.40062639117240906},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3642749786376953},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.151841402053833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14857131242752075},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08220085501670837},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2024.3393984","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3393984","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3b88dfba1a004d6d813115fe3ae0f842","is_oa":true,"landing_page_url":"https://doaj.org/article/3b88dfba1a004d6d813115fe3ae0f842","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 12, Pp 60112-60122 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2024.3393984","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2024.3393984","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321301","display_name":"Soonchunhyang University","ror":"https://ror.org/03qjsrb10"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1264889757","https://openalex.org/W1498647569","https://openalex.org/W1499760728","https://openalex.org/W1524327358","https://openalex.org/W1533692490","https://openalex.org/W1585096013","https://openalex.org/W1883887341","https://openalex.org/W1904057448","https://openalex.org/W1969405451","https://openalex.org/W1971482087","https://openalex.org/W1981082198","https://openalex.org/W2004779363","https://openalex.org/W2011571750","https://openalex.org/W2016061506","https://openalex.org/W2016446019","https://openalex.org/W2016810031","https://openalex.org/W2016854448","https://openalex.org/W2017346656","https://openalex.org/W2021407671","https://openalex.org/W2040023204","https://openalex.org/W2042273803","https://openalex.org/W2048689765","https://openalex.org/W2056222432","https://openalex.org/W2093225656","https://openalex.org/W2093729275","https://openalex.org/W2140372289","https://openalex.org/W2143703696","https://openalex.org/W2151048657","https://openalex.org/W2163815564","https://openalex.org/W2329115056","https://openalex.org/W2399044297","https://openalex.org/W2548186030","https://openalex.org/W2582220150","https://openalex.org/W2607586607","https://openalex.org/W2618188539","https://openalex.org/W2735828902","https://openalex.org/W2759190050","https://openalex.org/W2794356169","https://openalex.org/W2901910966","https://openalex.org/W2911761011","https://openalex.org/W2914751337","https://openalex.org/W2943025125","https://openalex.org/W2945164118","https://openalex.org/W2979693602","https://openalex.org/W2989399696","https://openalex.org/W2990150699","https://openalex.org/W2992707328","https://openalex.org/W3111993455","https://openalex.org/W3196024351","https://openalex.org/W3207308590","https://openalex.org/W4200546615","https://openalex.org/W4211013529","https://openalex.org/W4211129707","https://openalex.org/W4226406037","https://openalex.org/W4282590575","https://openalex.org/W4288693331","https://openalex.org/W4289985796","https://openalex.org/W4309781260","https://openalex.org/W4313461418","https://openalex.org/W6741288285","https://openalex.org/W6942087650"],"related_works":["https://openalex.org/W4301396970","https://openalex.org/W2006689666","https://openalex.org/W2550683708","https://openalex.org/W3146991102","https://openalex.org/W3010486731","https://openalex.org/W2899224757","https://openalex.org/W2015202629","https://openalex.org/W2094219890","https://openalex.org/W2013954586","https://openalex.org/W4280569028"],"abstract_inverted_index":{"Transcutaneous":[0],"auricular":[1],"vagus":[2],"nerve":[3],"stimulation":[4],"(taVNS)":[5],"could":[6,197],"be":[7,70],"a":[8,13,64,110,172],"promising":[9],"treatment":[10],"for":[11],"epilepsy,":[12],"neurological":[14],"disorder":[15],"primarily":[16],"characterized":[17],"by":[18,82,202,212,218],"seizures.":[19,220],"One":[20],"of":[21,25,67,104,127,143,150],"the":[22,55,92,102,105,113,124,137,166,199,204],"primary":[23],"causes":[24],"premature":[26],"mortality":[27],"in":[28,36,63,79,95,165,175,188],"patients":[29],"with":[30,49,182],"epilepsy":[31,37,68],"is":[32,46],"sudden":[33],"unexpected":[34],"death":[35],"(SUDEP).":[38],"Considering":[39],"that":[40,133,194],"reduced":[41],"heart":[42],"rate":[43],"variability":[44],"(HRV)":[45],"strongly":[47],"associated":[48],"SUDEP,":[50],"whether":[51],"taVNS":[52,88,134,196],"can":[53],"modify":[54],"autonomic":[56,106],"nervous":[57,107],"system":[58],"while":[59],"simultaneously":[60],"suppressing":[61],"seizures":[62,76],"rat":[65],"model":[66],"should":[69],"investigated.":[71],"In":[72],"this":[73],"study,":[74],"epileptic":[75,219],"were":[77,98,120],"induced":[78],"anesthetized":[80],"rats":[81],"administering":[83],"pentylenetetrazol":[84],"(PTZ)":[85],"and":[86,116,156,177,206],"performing":[87],"twice.":[89],"After":[90],"completing":[91],"experiments,":[93],"changes":[94],"HRV":[96,205],"measurements":[97],"analyzed":[99],"to":[100,122],"investigate":[101],"function":[103],"system.":[108],"From":[109],"histological":[111],"perspective,":[112],"Iba-1,":[114],"c-Fos,":[115],"GAD65":[117,189],"expression":[118],"levels":[119],"examined":[121],"evaluate":[123],"antiepileptic":[125,210],"effects":[126,211],"taVNS.":[128],"Our":[129],"study":[130,192],"results":[131],"revealed":[132,171],"significantly":[135],"improved":[136],"HRV,":[138],"including":[139],"root":[140],"mean":[141],"square":[142],"differences":[144],"between":[145],"N\u2013N":[146,152],"intervals,":[147,153],"standard":[148],"deviation":[149],"all":[151],"high-frequency":[154],"power,":[155],"total":[157],"power.":[158,168],"However,":[159],"no":[160,183],"significant":[161,173,185],"difference":[162,186],"was":[163],"observed":[164,187],"low-frequency":[167],"Histological":[169],"analysis":[170],"reduction":[174],"Iba-1":[176],"c-Fos":[178],"expressions":[179],"following":[180],"taVNS,":[181],"statistically":[184],"expression.":[190],"This":[191],"suggests":[193],"(1)":[195],"enhance":[198],"parasympathetic":[200],"activity":[201],"improving":[203],"(2)":[207],"potentially":[208],"exhibit":[209],"protecting":[213],"cells":[214],"from":[215],"damage":[216],"caused":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
