{"id":"https://openalex.org/W4379534644","doi":"https://doi.org/10.1109/access.2023.3283291","title":"Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean Networks","display_name":"Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean Networks","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4379534644","doi":"https://doi.org/10.1109/access.2023.3283291"},"language":"en","primary_location":{"id":"doi:10.1109/access.2023.3283291","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2023.3283291","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/10005208/10144738.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/10005208/10144738.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053718192","display_name":"Aditya Lahiri","orcid":"https://orcid.org/0000-0001-9352-1312"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Lahiri","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-9352-1312","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021324799","display_name":"Haswanth Vundavilli","orcid":"https://orcid.org/0000-0002-3283-7732"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haswanth Vundavilli","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-3283-7732","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070343161","display_name":"Madhurima Mondal","orcid":"https://orcid.org/0009-0007-0255-7020"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhurima Mondal","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057808634","display_name":"Pranabesh Bhattacharjee","orcid":"https://orcid.org/0000-0002-5630-1916"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranabesh Bhattacharjee","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-5630-1916","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108493716","display_name":"Brian S. Decker","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Decker","raw_affiliation_strings":["EMOL Health, Royal Oak, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMOL Health, Royal Oak, MI, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085328","display_name":"Giuseppe Del Priore","orcid":null},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Del Priore","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048860443","display_name":"N. Peter Reeves","orcid":"https://orcid.org/0000-0001-5021-7839"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Peter Reeves","raw_affiliation_strings":["Sumaq Life LLC, East Lansing, MI, USA"],"raw_orcid":"https://orcid.org/0000-0001-5021-7839","affiliations":[{"raw_affiliation_string":"Sumaq Life LLC, East Lansing, MI, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045462352","display_name":"Aniruddha Datta","orcid":"https://orcid.org/0000-0003-1213-3807"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddha Datta","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-1213-3807","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.0152,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73815969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"56672","last_page":"56690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"Triple-negative breast cancer","score":0.7572530508041382},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6220002174377441},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5621466636657715},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5383293628692627},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.5196020007133484},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.4945654571056366},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.44181200861930847},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.4346208870410919},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4044199287891388},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3232138156890869},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24645793437957764},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2030784785747528}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7572530508041382},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6220002174377441},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5621466636657715},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5383293628692627},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5196020007133484},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4945654571056366},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44181200861930847},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4346208870410919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4044199287891388},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3232138156890869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24645793437957764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2030784785747528}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2023.3283291","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2023.3283291","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/10005208/10144738.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e89407e89f8845e5a32f565ace271cb4","is_oa":true,"landing_page_url":"https://doaj.org/article/e89407e89f8845e5a32f565ace271cb4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 11, Pp 56672-56690 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2023.3283291","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2023.3283291","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/10005208/10144738.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G6408125998","display_name":"Cancer Therapeutics through Theory and Experiment: From Cell Lines to Canine Tumors Grown on the Back of Mice","funder_award_id":"1917166","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7386708321","display_name":"I-Corps:  Model-driven precision oncology for cancer therapy design","funder_award_id":"2136215","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379534644.pdf","grobid_xml":"https://content.openalex.org/works/W4379534644.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W183361337","https://openalex.org/W1256125786","https://openalex.org/W1487904588","https://openalex.org/W1501944221","https://openalex.org/W1527441981","https://openalex.org/W1969547738","https://openalex.org/W1971224531","https://openalex.org/W1977657574","https://openalex.org/W1979521500","https://openalex.org/W1979946545","https://openalex.org/W1984852348","https://openalex.org/W1987388371","https://openalex.org/W1987395624","https://openalex.org/W1993320949","https://openalex.org/W1997124480","https://openalex.org/W1998620046","https://openalex.org/W2001809193","https://openalex.org/W2002127663","https://openalex.org/W2004480757","https://openalex.org/W2006444511","https://openalex.org/W2009094422","https://openalex.org/W2011366619","https://openalex.org/W2016429826","https://openalex.org/W2018867485","https://openalex.org/W2019708706","https://openalex.org/W2023427658","https://openalex.org/W2028356733","https://openalex.org/W2035008060","https://openalex.org/W2036058623","https://openalex.org/W2040430549","https://openalex.org/W2043140203","https://openalex.org/W2053009900","https://openalex.org/W2053680453","https://openalex.org/W2058865073","https://openalex.org/W2061294496","https://openalex.org/W2062029454","https://openalex.org/W2066824183","https://openalex.org/W2068774293","https://openalex.org/W2076647600","https://openalex.org/W2076883893","https://openalex.org/W2077582389","https://openalex.org/W2080354187","https://openalex.org/W2081107312","https://openalex.org/W2086828029","https://openalex.org/W2093829133","https://openalex.org/W2096283457","https://openalex.org/W2096595244","https://openalex.org/W2099139312","https://openalex.org/W2102912734","https://openalex.org/W2106292881","https://openalex.org/W2122634943","https://openalex.org/W2126606149","https://openalex.org/W2128775062","https://openalex.org/W2134539328","https://openalex.org/W2135340303","https://openalex.org/W2135487116","https://openalex.org/W2140154342","https://openalex.org/W2140350596","https://openalex.org/W2141589190","https://openalex.org/W2147135997","https://openalex.org/W2147373929","https://openalex.org/W2148678536","https://openalex.org/W2150026213","https://openalex.org/W2153086428","https://openalex.org/W2155898089","https://openalex.org/W2156142377","https://openalex.org/W2158627893","https://openalex.org/W2160928966","https://openalex.org/W2161415513","https://openalex.org/W2170602872","https://openalex.org/W2170833808","https://openalex.org/W2172133051","https://openalex.org/W2218503759","https://openalex.org/W2343858832","https://openalex.org/W2403789873","https://openalex.org/W2419558864","https://openalex.org/W2495853214","https://openalex.org/W2509794319","https://openalex.org/W2529254819","https://openalex.org/W2550960324","https://openalex.org/W2551065090","https://openalex.org/W2562852255","https://openalex.org/W2574407248","https://openalex.org/W2609790482","https://openalex.org/W2611621738","https://openalex.org/W2718751133","https://openalex.org/W2722321450","https://openalex.org/W2736907523","https://openalex.org/W2755285110","https://openalex.org/W2772285990","https://openalex.org/W2794734792","https://openalex.org/W2795063553","https://openalex.org/W2801501414","https://openalex.org/W2803256996","https://openalex.org/W2886489770","https://openalex.org/W2890400107","https://openalex.org/W2891566202","https://openalex.org/W2897942487","https://openalex.org/W2900808021","https://openalex.org/W2901896725","https://openalex.org/W2908260091","https://openalex.org/W2911718257","https://openalex.org/W2914973295","https://openalex.org/W2918147447","https://openalex.org/W2939566402","https://openalex.org/W2946899637","https://openalex.org/W2958690036","https://openalex.org/W2962063966","https://openalex.org/W2965843226","https://openalex.org/W2969775100","https://openalex.org/W2970322015","https://openalex.org/W2973459418","https://openalex.org/W3004866745","https://openalex.org/W3005100596","https://openalex.org/W3010774829","https://openalex.org/W3011169619","https://openalex.org/W3012124203","https://openalex.org/W3029713306","https://openalex.org/W3031214633","https://openalex.org/W3037926313","https://openalex.org/W3040197465","https://openalex.org/W3086332450","https://openalex.org/W3093085805","https://openalex.org/W3093877036","https://openalex.org/W3105073783","https://openalex.org/W3119005666","https://openalex.org/W3128646645","https://openalex.org/W3131387891","https://openalex.org/W3133775961","https://openalex.org/W3134553072","https://openalex.org/W3147142721","https://openalex.org/W3154614489","https://openalex.org/W3155531365","https://openalex.org/W3157447802","https://openalex.org/W3157825400","https://openalex.org/W3165720345","https://openalex.org/W3167845759","https://openalex.org/W3188787409","https://openalex.org/W3205209667","https://openalex.org/W3212723841","https://openalex.org/W3217209761","https://openalex.org/W4220663959","https://openalex.org/W4224210467","https://openalex.org/W4226461797","https://openalex.org/W4246703595","https://openalex.org/W4285006401","https://openalex.org/W4285391272","https://openalex.org/W4285992810"],"related_works":["https://openalex.org/W1535396021","https://openalex.org/W4362432751","https://openalex.org/W3030228103","https://openalex.org/W4403748199","https://openalex.org/W4391693858","https://openalex.org/W2903919886","https://openalex.org/W2064898491","https://openalex.org/W2156193942","https://openalex.org/W2150479858","https://openalex.org/W2030161097"],"abstract_inverted_index":{"Triple-negative":[0],"breast":[1,9,35],"cancer":[2,10,36,102],"(TNBC)":[3],"is":[4,49,54,60],"an":[5,13],"aggressive":[6],"form":[7],"of":[8,16,32,77,105,147,171,194,240],"associated":[11],"with":[12,168,204],"early":[14],"age":[15],"onset,":[17],"greater":[18],"propensity":[19],"towards":[20],"metastasis,":[21],"and":[22,38,96,140],"poorer":[23],"clinical":[24],"outcomes.":[25],"It":[26],"accounts":[27],"for":[28,187],"10%":[29],"to":[30,51,57,73,143,217],"20%":[31],"newly":[33],"diagnosed":[34],"cases":[37],"disproportionately":[39],"affects":[40],"individuals":[41],"from":[42,136],"the":[43,65,75,101,106,124,134,137,145,158,161,183,195,199,205,215,233],"African":[44],"American":[45],"race.":[46],"While":[47],"TNBC":[48,67,78,81,107,219],"sensitive":[50],"chemotherapy,":[52],"it":[53,142],"also":[55],"prone":[56],"relapse.":[58,220],"This":[59],"because":[61],"chemotherapy":[62],"successfully":[63],"targets":[64,186],"primary":[66],"tumor":[68],"cell":[69,89],"but":[70],"often":[71],"fails":[72],"target":[74],"subpopulation":[76],"stem":[79,82,108],"cells.":[80],"cells":[83],"display":[84],"cancerous":[85],"traits":[86],"such":[87],"as":[88,229],"cycle":[90],"progression,":[91],"survival,":[92],"proliferation,":[93],"apoptosis":[94],"inhibition,":[95],"epithelial-mesenchymal":[97],"transition.":[98],"To":[99],"study":[100],"initiating":[103],"behavior":[104],"cells,":[109],"we":[110,236],"studied":[111],"their":[112],"underlying":[113],"signaling":[114,130],"pathways":[115,162],"using":[116],"Boolean":[117],"networks(BN).":[118],"BNs":[119],"are":[120,191],"effective":[121],"in":[122,129,152,198,232],"capturing":[123],"causal":[125],"interactions":[126],"taking":[127],"place":[128],"pathways.":[131],"We":[132,156],"built":[133],"BN":[135,159],"pathway":[138],"literature":[139],"used":[141],"evaluate":[144],"efficacies":[146,227],"eleven":[148],"targeted":[149],"inhibitory":[150],"drugs":[151,241],"suppressing":[153],"cancer-promoting":[154,196],"genes.":[155],"simulated":[157],"when":[160],"had":[163],"single":[164,245],"or":[165],"multiple":[166],"mutations,":[167],"a":[169,175],"maximum":[170],"three":[172,212],"mutations":[173,230],"at":[174],"time.":[176],"Our":[177],"findings":[178],"indicated":[179],"thatSTAT3,GLI,":[180],"andNF-$\\kappa":[181],"$Bare":[182],"most":[184],"optimal":[185],"inhibition.":[188],"These":[189],"genes":[190,197,213],"known":[192],"regulators":[193],"pathway,hence":[200],"our":[201,222],"model":[202],"agrees":[203],"existing":[206],"biological":[207],"literature.":[208],"Therefore":[209],"inhibiting":[210],"these":[211],"has":[214],"potential":[216],"prevent":[218],"Additionally,":[221],"studies":[223],"found":[224],"that":[225,238],"drug":[226],"decreased":[228],"increased":[231],"pathway.":[234],"Furthermore,":[235],"noticed":[237],"combinations":[239],"performed":[242],"better":[243],"than":[244],"drugs.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}
