{"id":"https://openalex.org/W4206656700","doi":"https://doi.org/10.1109/access.2021.3132401","title":"Automatic Detection of Amyloid Beta Plaques in Somatosensory Cortex of an Alzheimer\u2019s Disease Mouse Using Deep Learning","display_name":"Automatic Detection of Amyloid Beta Plaques in Somatosensory Cortex of an Alzheimer\u2019s Disease Mouse Using Deep Learning","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4206656700","doi":"https://doi.org/10.1109/access.2021.3132401"},"language":"en","primary_location":{"id":"doi:10.1109/access.2021.3132401","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3132401","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/09634031.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/09634031.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011106145","display_name":"Heemoon Yoon","orcid":"https://orcid.org/0000-0002-6655-5485"},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Heemoon Yoon","raw_affiliation_strings":["School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia"],"affiliations":[{"raw_affiliation_string":"School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080980747","display_name":"Mi\u2010Ra Park","orcid":"https://orcid.org/0000-0003-0175-8692"},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mira Park","raw_affiliation_strings":["School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia"],"affiliations":[{"raw_affiliation_string":"School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057089774","display_name":"Soonja Yeom","orcid":"https://orcid.org/0000-0002-5843-101X"},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Soonja Yeom","raw_affiliation_strings":["School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia"],"affiliations":[{"raw_affiliation_string":"School of Information and Communications Technology, University of Tasmania, Hobart, TAS 7001, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080194589","display_name":"Matthew Kirkcaldie","orcid":"https://orcid.org/0000-0003-3285-0168"},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew T. K. Kirkcaldie","raw_affiliation_strings":["Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia"],"affiliations":[{"raw_affiliation_string":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016378372","display_name":"Peter Summons","orcid":"https://orcid.org/0000-0002-0672-2616"},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Summons","raw_affiliation_strings":["School of Information and Physical Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia"],"affiliations":[{"raw_affiliation_string":"School of Information and Physical Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100358397","display_name":"Sang\u2010Hee Lee","orcid":"https://orcid.org/0000-0001-8725-4174"},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Hee Lee","raw_affiliation_strings":["Department of Animal Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea. (e-mail: sang1799@kangwon.ac.kr)","Department of Animal Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Animal Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea. (e-mail: sang1799@kangwon.ac.kr)","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Department of Animal Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011106145"],"corresponding_institution_ids":["https://openalex.org/I129801699"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.6002,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67636478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"161926","last_page":"161936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7081500887870789},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7059301137924194},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6738687753677368},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.6079807281494141},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6022230982780457},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.587500810623169},{"id":"https://openalex.org/keywords/somatosensory-system","display_name":"Somatosensory system","score":0.5150458812713623},{"id":"https://openalex.org/keywords/s\u00f8rensen\u2013dice-coefficient","display_name":"S\u00f8rensen\u2013Dice coefficient","score":0.4821840822696686},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"Amyloid beta","score":0.46929818391799927},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.45707637071609497},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.43880751729011536},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4313565790653229},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.40620553493499756},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.30134159326553345},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2239314317703247},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2137540876865387},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.15012392401695251}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7081500887870789},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7059301137924194},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6738687753677368},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.6079807281494141},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6022230982780457},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.587500810623169},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.5150458812713623},{"id":"https://openalex.org/C163892561","wikidata":"https://www.wikidata.org/wiki/Q2613728","display_name":"S\u00f8rensen\u2013Dice coefficient","level":4,"score":0.4821840822696686},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.46929818391799927},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45707637071609497},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.43880751729011536},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4313565790653229},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.40620553493499756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30134159326553345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2239314317703247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2137540876865387},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15012392401695251}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/access.2021.3132401","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3132401","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/09634031.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:eprints.utas.edu.au:45862","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922975","display_name":"UTAS Research Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:703dd58d21f041c683adf2471ded7c3d","is_oa":true,"landing_page_url":"https://doaj.org/article/703dd58d21f041c683adf2471ded7c3d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 9, Pp 161926-161936 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2021.3132401","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3132401","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/6514899/09634031.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2581426252","display_name":null,"funder_award_id":"NRF 2019R1I1A1A01060932","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G834017027","display_name":null,"funder_award_id":"ACCESS","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G8565607864","display_name":null,"funder_award_id":"2019R1I1A1A01060932","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320310746","display_name":"Judith Jane Mason and Harold Stannett Williams Memorial Foundation","ror":null},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206656700.pdf","grobid_xml":"https://content.openalex.org/works/W4206656700.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1565050238","https://openalex.org/W1891773028","https://openalex.org/W1901129140","https://openalex.org/W1923697677","https://openalex.org/W1968114652","https://openalex.org/W1974565082","https://openalex.org/W1975141413","https://openalex.org/W1987153816","https://openalex.org/W1995450389","https://openalex.org/W2004293194","https://openalex.org/W2010587020","https://openalex.org/W2012215271","https://openalex.org/W2024806220","https://openalex.org/W2032377318","https://openalex.org/W2035419215","https://openalex.org/W2045404628","https://openalex.org/W2052742260","https://openalex.org/W2068403136","https://openalex.org/W2082526668","https://openalex.org/W2092497652","https://openalex.org/W2095690392","https://openalex.org/W2102099319","https://openalex.org/W2102214751","https://openalex.org/W2104759243","https://openalex.org/W2122632052","https://openalex.org/W2126867710","https://openalex.org/W2131051578","https://openalex.org/W2132987911","https://openalex.org/W2133059825","https://openalex.org/W2154579312","https://openalex.org/W2159286928","https://openalex.org/W2160172739","https://openalex.org/W2163383667","https://openalex.org/W2163605009","https://openalex.org/W2170925557","https://openalex.org/W2183182206","https://openalex.org/W2243214635","https://openalex.org/W2319937903","https://openalex.org/W2329336071","https://openalex.org/W2337016337","https://openalex.org/W2403220016","https://openalex.org/W2567599812","https://openalex.org/W2570634615","https://openalex.org/W2741481567","https://openalex.org/W2766959165","https://openalex.org/W2875369846","https://openalex.org/W2889808182","https://openalex.org/W2889974603","https://openalex.org/W2903517662","https://openalex.org/W2903742167","https://openalex.org/W2904299531","https://openalex.org/W2910758210","https://openalex.org/W2914196409","https://openalex.org/W2937205530","https://openalex.org/W2941195539","https://openalex.org/W2963881378","https://openalex.org/W3023571983","https://openalex.org/W3040423171","https://openalex.org/W3049388525","https://openalex.org/W3100262678","https://openalex.org/W3141513909","https://openalex.org/W3152994446","https://openalex.org/W3211573487","https://openalex.org/W6610017368","https://openalex.org/W6640295612","https://openalex.org/W6682751323","https://openalex.org/W6684191040","https://openalex.org/W6690411370","https://openalex.org/W6734220160","https://openalex.org/W6761303919","https://openalex.org/W6803356969"],"related_works":["https://openalex.org/W3197743961","https://openalex.org/W3147271662","https://openalex.org/W3119036072","https://openalex.org/W2802576082","https://openalex.org/W2066263898","https://openalex.org/W2051204854","https://openalex.org/W1989972829","https://openalex.org/W4378904708","https://openalex.org/W2030046976","https://openalex.org/W1261866575"],"abstract_inverted_index":{"Identification":[0],"of":[1,12,17,38,97,144,148,174,186,191],"amyloid":[2],"beta":[3],"(A\u03b2)":[4],"plaques":[5,34,105],"in":[6,10,35,183],"the":[7,36,80,134,149,157,165,170,184],"cerebral":[8],"cortex":[9,37,167],"models":[11],"Alzheimer\u2019s":[13],"Disease":[14],"(AD)":[15],"is":[16],"critical":[18],"importance":[19],"for":[20,153],"research":[21],"into":[22],"therapeutics.":[23],"Here":[24],"we":[25],"propose":[26],"an":[27,75,85,142],"innovative":[28],"framework":[29,52,140,162],"which":[30],"automatically":[31,163],"measures":[32],"A\u03b2":[33,90,103,175],"a":[39,47,69,195],"rodent":[40],"model,":[41,82],"based":[42],"on":[43],"anatomical":[44,76],"segmentation":[45,77,137,155],"using":[46,62,79,194],"deep":[48,111,196],"learning":[49,197],"approach.":[50,198],"The":[51,139,160],"has":[53],"three":[54],"phases:":[55],"data":[56],"acquisition":[57],"to":[58,88,180],"enhance":[59],"image":[60,66,181,192],"quality":[61],"preprocessing":[63],"techniques":[64],"and":[65,83,122,146,168,172],"normalization":[67],"with":[68,94,110,156],"novel":[70],"plaque":[71],"removal":[72],"algorithm,":[73],"then":[74],"phase":[78,87],"trained":[81,109],"finally":[84],"analysis":[86,182],"quantitate":[89],"plaques.":[91,176],"Supervised":[92],"training":[93],"946":[95],"sets":[96],"mouse":[98],"brain":[99],"section":[100],"annotations":[101],"exhibiting":[102],"protein-labeled":[104],"(A\u03b2":[106],"plaques)":[107],"were":[108,124],"neural":[112],"networks":[113],"(DNNs).":[114],"Five":[115],"DNN":[116],"architectures:":[117],"FCN32,":[118],"FCN16,":[119],"FCN8,":[120],"SegNet,":[121],"U-Net,":[123],"tested.":[125],"Of":[126],"these,":[127],"U-Net":[128],"was":[129],"selected":[130],"as":[131],"it":[132],"showed":[133],"most":[135],"reliable":[136],"performance.":[138],"demonstrated":[141],"accuracy":[143],"83.98%":[145],"91.21%":[147],"Dice":[150],"coefficient":[151],"score":[152],"atlas":[154],"test":[158],"dataset.":[159],"proposed":[161],"segmented":[164],"somatosensory":[166],"calculated":[169],"intensity":[171],"extent":[173],"This":[177],"study":[178],"contributes":[179],"field":[185],"neuroscience,":[187],"allowing":[188],"region-specific":[189],"quantitation":[190],"features":[193]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}