{"id":"https://openalex.org/W3207759570","doi":"https://doi.org/10.1109/access.2021.3120448","title":"A Two-Stage Separation of Circulating Tumor Cells Based on Deterministic Lateral Displacement and Dielectrophoresis Techniques","display_name":"A Two-Stage Separation of Circulating Tumor Cells Based on Deterministic Lateral Displacement and Dielectrophoresis Techniques","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3207759570","doi":"https://doi.org/10.1109/access.2021.3120448","mag":"3207759570"},"language":"en","primary_location":{"id":"doi:10.1109/access.2021.3120448","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3120448","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2021.3120448","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072457818","display_name":"Yanjuan Wang","orcid":"https://orcid.org/0000-0003-0812-5732"},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjuan Wang","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":"https://orcid.org/0000-0003-0812-5732","affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024812425","display_name":"Chengxiao Wang","orcid":"https://orcid.org/0000-0003-2858-8099"},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengxiao Wang","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613470","display_name":"Yunfei Zhang","orcid":"https://orcid.org/0000-0002-8123-7805"},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunfei Zhang","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108904913","display_name":"Meiqi Han","orcid":null},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiqi Han","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013849293","display_name":"Yangjinyu Li","orcid":null},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangjinyu Li","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043390589","display_name":"Shanyu Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanyu Jin","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100510870","display_name":"Haiqi He","orcid":null},"institutions":[{"id":"https://openalex.org/I7350606","display_name":"Dalian Jiaotong University","ror":"https://ror.org/05gp45n31","country_code":"CN","type":"education","lineage":["https://openalex.org/I7350606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiqi He","raw_affiliation_strings":["Software Institute, Dalian Jiaotong University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Institute, Dalian Jiaotong University, Dalian, China","institution_ids":["https://openalex.org/I7350606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7350606"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.6535,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.62548002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"143847","last_page":"143859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dielectrophoresis","display_name":"Dielectrophoresis","score":0.8155933618545532},{"id":"https://openalex.org/keywords/circulating-tumor-cell","display_name":"Circulating tumor cell","score":0.5833414793014526},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.559575617313385},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.5080122947692871},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4516056776046753},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4122884273529053},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.3899044692516327},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3821560740470886},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.28130999207496643},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.27609413862228394},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.22029954195022583},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15216922760009766},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10433131456375122}],"concepts":[{"id":"https://openalex.org/C106825181","wikidata":"https://www.wikidata.org/wiki/Q902890","display_name":"Dielectrophoresis","level":3,"score":0.8155933618545532},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.5833414793014526},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.559575617313385},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.5080122947692871},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4516056776046753},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4122884273529053},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.3899044692516327},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3821560740470886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28130999207496643},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.27609413862228394},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.22029954195022583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15216922760009766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10433131456375122},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2021.3120448","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3120448","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d9b8bf36f52742ca9936adb3163136c0","is_oa":true,"landing_page_url":"https://doaj.org/article/d9b8bf36f52742ca9936adb3163136c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 9, Pp 143847-143859 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2021.3120448","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3120448","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G1246816837","display_name":null,"funder_award_id":"2017YFC1404606","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3128416429","display_name":null,"funder_award_id":"2018J11CY021","funder_id":"https://openalex.org/F4320336584","funder_display_name":"Dalian Science and Technology Innovation Fund"},{"id":"https://openalex.org/G339442330","display_name":null,"funder_award_id":"51779027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4203065880","display_name":null,"funder_award_id":"2017YFC1404603","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4719193168","display_name":null,"funder_award_id":"2019-MS-025","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G6058717031","display_name":null,"funder_award_id":"XLYC1807036","funder_id":"https://openalex.org/F4320329895","funder_display_name":"Liaoning Revitalization Talents Program"},{"id":"https://openalex.org/G610851811","display_name":null,"funder_award_id":"52005071","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6341091415","display_name":null,"funder_award_id":"2019-ZD-0089","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320329895","display_name":"Liaoning Revitalization Talents Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336584","display_name":"Dalian Science and Technology Innovation Fund","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1524833541","https://openalex.org/W1543089374","https://openalex.org/W1591710544","https://openalex.org/W1911720892","https://openalex.org/W1960278053","https://openalex.org/W1971102544","https://openalex.org/W1971381614","https://openalex.org/W1972867200","https://openalex.org/W1975214851","https://openalex.org/W1978142481","https://openalex.org/W1982760718","https://openalex.org/W1988580725","https://openalex.org/W2006618445","https://openalex.org/W2008133559","https://openalex.org/W2018050443","https://openalex.org/W2022234108","https://openalex.org/W2031065792","https://openalex.org/W2041695600","https://openalex.org/W2057588529","https://openalex.org/W2102864709","https://openalex.org/W2113716299","https://openalex.org/W2119494825","https://openalex.org/W2125051097","https://openalex.org/W2139958356","https://openalex.org/W2169498835","https://openalex.org/W2223822801","https://openalex.org/W2288173717","https://openalex.org/W2293262370","https://openalex.org/W2313329151","https://openalex.org/W2531142395","https://openalex.org/W2589485736","https://openalex.org/W2614006786","https://openalex.org/W2617704676","https://openalex.org/W2624772617","https://openalex.org/W2752013568","https://openalex.org/W2756936191","https://openalex.org/W2760818114","https://openalex.org/W2761914570","https://openalex.org/W2778253740","https://openalex.org/W2782129578","https://openalex.org/W2795399048","https://openalex.org/W2804637298","https://openalex.org/W2891943120","https://openalex.org/W2897867924","https://openalex.org/W2911942093","https://openalex.org/W2921405735","https://openalex.org/W2927504341","https://openalex.org/W2939819428","https://openalex.org/W2945991933","https://openalex.org/W2960709096","https://openalex.org/W2963716757","https://openalex.org/W2968295456","https://openalex.org/W2973761847","https://openalex.org/W2974417314","https://openalex.org/W2977593842","https://openalex.org/W2981859636","https://openalex.org/W3000641549","https://openalex.org/W3004325570","https://openalex.org/W3005811714","https://openalex.org/W3023476392","https://openalex.org/W3034219042","https://openalex.org/W3044318460","https://openalex.org/W3082805140","https://openalex.org/W3086061480","https://openalex.org/W3089565219","https://openalex.org/W3119014941","https://openalex.org/W3123068496","https://openalex.org/W3125143351","https://openalex.org/W3129836396","https://openalex.org/W6641093874","https://openalex.org/W6738470768"],"related_works":["https://openalex.org/W2949555527","https://openalex.org/W3105048124","https://openalex.org/W4244444919","https://openalex.org/W2394297731","https://openalex.org/W1986695625","https://openalex.org/W2240397985","https://openalex.org/W2058246061","https://openalex.org/W2111768126","https://openalex.org/W4286284840","https://openalex.org/W2356576053"],"abstract_inverted_index":{"Circulating":[0],"tumor":[1],"cells":[2,6,87,131,152,176,188,207],"(CTCs)":[3],"are":[4,22,32],"cancer":[5,11,28,86],"that":[7,55,170],"fall":[8],"off":[9],"from":[10],"lesions":[12],"and":[13,61,105,111,129,156,191,196,223],"enter":[14],"the":[15,23,75,78,81,96,106,112,122,125,139,150,172,192,202,221],"blood":[16,94],"of":[17,26,77,109,127,186,205,225],"human":[18,82,93],"extracorporeal":[19],"circulation.":[20],"They":[21],"early":[24],"basis":[25],"judging":[27],"metastasis.":[29],"However,":[30,119],"CTCs":[31,52,226],"extremely":[33],"rare,":[34],"there":[35],"is":[36],"a":[37,50,99,142,217],"great":[38],"challenge":[39],"to":[40,45,73,121,148,161,220],"create":[41],"an":[42],"effective":[43],"platform":[44],"isolate":[46],"these":[47],"cells.":[48],"Herein,":[49],"two-stage":[51,173],"separation":[53,126,184,222],"method":[54],"combines":[56],"deterministic":[57],"lateral":[58],"displacement":[59],"(DLD)":[60],"dielectrophoresis":[62],"(DEP)":[63],"technology":[64],"based":[65,116],"on":[66,117],"microfluidic":[67],"chips":[68],"was":[69,103,146,189,194,211],"proposed.":[70],"In":[71,138,200],"order":[72],"verify":[74],"effectiveness":[76],"proposed":[79],"method,":[80],"non-small":[83],"cell":[84],"lung":[85],"(H322)":[88],"were":[89,114],"spiked":[90],"into":[91],"diluted":[92],"as":[95],"samples.":[97],"Firstly,":[98],"designed":[100],"DLD":[101,136],"chip":[102,145],"used,":[104],"overwhelming":[107],"majority":[108],"RBCs":[110],"platelets":[113],"removed":[115],"size.":[118],"due":[120],"size":[123],"overlapping,":[124],"WBCs":[128,155],"H322":[130,175,187,206],"cannot":[132],"be":[133,181],"achieved":[134],"by":[135],"technology.":[137],"second":[140],"stage,":[141],"novel":[143],"DEP":[144,203],"used":[147],"separate":[149],"mixed":[151],"(H322":[153],"cells,":[154],"few":[157],"residual":[158],"RBCs)":[159],"according":[160],"their":[162],"difference":[163],"dielectric":[164],"properties.":[165],"The":[166,183],"experimental":[167],"results":[168],"show":[169],"after":[171],"separation,":[174],"with":[177],"high":[178],"purity":[179,193],"can":[180],"obtained.":[182],"efficiency":[185],"91&#x0025;,":[190],"80.7&#x0025;,":[195],"maintains":[197],"its":[198],"activity.":[199],"addition,":[201],"response":[204],"under":[208],"various":[209],"frequencies":[210],"investigated.":[212],"Those":[213],"findings":[214],"will":[215],"provide":[216],"useful":[218],"reference":[219],"enrichment":[224],"in":[227],"peripheral":[228],"blood.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2025-10-10T00:00:00"}
