{"id":"https://openalex.org/W3123598243","doi":"https://doi.org/10.1109/access.2021.3054162","title":"Toward Identifying Key Gene Group in the Occurrence and Development of Lung Adenocarcinoma","display_name":"Toward Identifying Key Gene Group in the Occurrence and Development of Lung Adenocarcinoma","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3123598243","doi":"https://doi.org/10.1109/access.2021.3054162","mag":"3123598243"},"language":"en","primary_location":{"id":"doi:10.1109/access.2021.3054162","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3054162","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09336719.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09336719.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033955686","display_name":"Ming Gu","orcid":"https://orcid.org/0000-0003-0469-3601"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Gu","raw_affiliation_strings":["School of Basic Medical Science, Southern Medical University, Guangzhou, China","School of Computer Science and Engineering, South China University of Technology, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-0469-3601","affiliations":[{"raw_affiliation_string":"School of Basic Medical Science, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Computer Science and Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080225526","display_name":"Tian-Fang Zhao","orcid":"https://orcid.org/0000-0002-3520-2951"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian-Fang Zhao","raw_affiliation_strings":["School of Computer Science and Engineering, South China University of Technology, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3520-2951","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431831","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0002-5739-9986"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["School of Foreign Languages, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Foreign Languages, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039590256","display_name":"Xiao-Kun Wu","orcid":"https://orcid.org/0000-0003-3843-0164"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Kun Wu","raw_affiliation_strings":["School of Computer Science and Engineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003769188","display_name":"Liang Yang","orcid":"https://orcid.org/0000-0001-6291-4359"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210156404","display_name":"Institute of Information Engineering","ror":"https://ror.org/04r53se39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210156404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Yang","raw_affiliation_strings":["Hebei Province Key Laboratory of Big Data Calculation, Hebei University of Technology, Tianjin, China","School of Artificial Intelligence, Hebei University of Technology, Tianjin, China","State Key Laboratory of Information Security, Institute of Information Engineering, Chinese Academy of Sciences (CAS), Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6291-4359","affiliations":[{"raw_affiliation_string":"Hebei Province Key Laboratory of Big Data Calculation, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Artificial Intelligence, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"State Key Laboratory of Information Security, Institute of Information Engineering, Chinese Academy of Sciences (CAS), Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210156404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.074,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37563126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9","issue":null,"first_page":"26156","last_page":"26167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.8609813451766968},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6080796122550964},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-1","display_name":"Cyclin-dependent kinase 1","score":0.5583561658859253},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.5253291130065918},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4924348294734955},{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.47705355286598206},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4719005525112152},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45155584812164307},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2858802378177643},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2756233811378479},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.23850548267364502}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8609813451766968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6080796122550964},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5583561658859253},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5253291130065918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4924348294734955},{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.47705355286598206},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4719005525112152},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45155584812164307},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2858802378177643},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2756233811378479},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.23850548267364502}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2021.3054162","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3054162","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09336719.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:baad49fedea94aeaa163b1fcc7c5dfcb","is_oa":true,"landing_page_url":"https://doaj.org/article/baad49fedea94aeaa163b1fcc7c5dfcb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 9, Pp 26156-26167 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2021.3054162","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3054162","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09336719.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3628717404","display_name":"\u9762\u5411\u5f02\u6784\u62d3\u6251\u4e0e\u8bed\u4e49\u878d\u5408\u7684\u5927\u89c4\u6a21\u7f51\u7edc\u5212\u5206\u7814\u7a76","funder_award_id":"61972442","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3991582358","display_name":null,"funder_award_id":"F2020202040","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"},{"id":"https://openalex.org/G4857815385","display_name":null,"funder_award_id":"20JCYBJC00650","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3123598243.pdf","grobid_xml":"https://content.openalex.org/works/W3123598243.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1505776747","https://openalex.org/W1953677527","https://openalex.org/W1966011301","https://openalex.org/W1971636041","https://openalex.org/W1989188414","https://openalex.org/W1997934236","https://openalex.org/W1999025078","https://openalex.org/W2019428861","https://openalex.org/W2020391983","https://openalex.org/W2020541351","https://openalex.org/W2051676630","https://openalex.org/W2053272914","https://openalex.org/W2057272791","https://openalex.org/W2059063362","https://openalex.org/W2068316132","https://openalex.org/W2074938547","https://openalex.org/W2077868815","https://openalex.org/W2080791584","https://openalex.org/W2087051531","https://openalex.org/W2107350938","https://openalex.org/W2119254941","https://openalex.org/W2119825923","https://openalex.org/W2133465414","https://openalex.org/W2136850043","https://openalex.org/W2149662085","https://openalex.org/W2158217645","https://openalex.org/W2158377043","https://openalex.org/W2159192794","https://openalex.org/W2159675211","https://openalex.org/W2262992387","https://openalex.org/W2280957887","https://openalex.org/W2305593924","https://openalex.org/W2318081164","https://openalex.org/W2325642881","https://openalex.org/W2331746516","https://openalex.org/W2339270760","https://openalex.org/W2410426698","https://openalex.org/W2518890317","https://openalex.org/W2621171915","https://openalex.org/W2740325081","https://openalex.org/W2751089373","https://openalex.org/W2753391559","https://openalex.org/W2767972229","https://openalex.org/W2781525129","https://openalex.org/W2794616841","https://openalex.org/W2801478434","https://openalex.org/W2804676460","https://openalex.org/W2810062868","https://openalex.org/W2889646458","https://openalex.org/W2894097912","https://openalex.org/W2895788438","https://openalex.org/W2900569176","https://openalex.org/W2908554896","https://openalex.org/W2918988263","https://openalex.org/W2921351876","https://openalex.org/W2921596575","https://openalex.org/W2931155850","https://openalex.org/W2938618790","https://openalex.org/W2943618951","https://openalex.org/W2945033315","https://openalex.org/W2947095040","https://openalex.org/W2954754264","https://openalex.org/W2965270240","https://openalex.org/W2974758797","https://openalex.org/W2989609784","https://openalex.org/W2997104189","https://openalex.org/W3006088245","https://openalex.org/W3006750504","https://openalex.org/W3007216823","https://openalex.org/W3007803076","https://openalex.org/W3047925669","https://openalex.org/W3082544518","https://openalex.org/W6770878112"],"related_works":["https://openalex.org/W169077027","https://openalex.org/W3110262097","https://openalex.org/W2741084198","https://openalex.org/W2129698514","https://openalex.org/W2551169910","https://openalex.org/W1592414993","https://openalex.org/W4315928186","https://openalex.org/W2439277778","https://openalex.org/W2038702757","https://openalex.org/W2167676426"],"abstract_inverted_index":{"Lung":[0],"adenocarcinoma":[1],"(LUAD)":[2],"has":[3],"become":[4],"the":[5,17,26,29,47,52,68,73,78,99,107,114,122,128,145,149,152,172,184,191,199,206,213,224,232,238,251],"most":[6],"common":[7],"pathological":[8,192],"type":[9],"of":[10,20,33,186,194,242,255],"lung":[11],"cancer":[12],"in":[13,28,55,151,183,205,237],"recent":[14],"years.":[15],"However,":[16],"molecular":[18],"mechanism":[19],"LUAD":[21,45],"remains":[22],"unclear.":[23],"To":[24],"reveal":[25],"laws":[27],"occurrence":[30,239],"and":[31,46,110,126,148,180,188,240,253],"development":[32,241],"LUAD,":[34,187],"this":[35,91],"paper":[36,92],"first":[37,118],"collects":[38],"676":[39],"differentially":[40],"expressed":[41],"genes":[42,75,84,116,138,141,147,150,162,201,234],"related":[43],"to":[44,104,121,143,171,190],"corresponding":[48],"proteins":[49],"encoded":[50],"by":[51,212],"genes,":[53,226],"resulting":[54],"a":[56,94,166,229],"complex":[57],"protein-protein":[58],"interaction":[59,70],"(PPI)":[60],"network.":[61],"The":[62,136],"traditional":[63],"analysis":[64,96,102],"methods":[65],"focus":[66],"on":[67],"gene":[69,101,157,167,173],"relationships":[71],"or":[72],"important":[74,82,111,204],"separately,":[76],"ignoring":[77],"fact":[79],"that":[80,176,198,231],"some":[81,140,218],"target":[83],"may":[85,235],"take":[86],"effect":[87],"jointly.":[88],"In":[89],"contrast,":[90],"adopts":[93],"new":[95],"method":[97,103],"named":[98],"overlapping":[100,137],"screen":[105],"out":[106],"closely":[108],"interacted":[109],"genes.":[112],"Thereinto,":[113],"hub":[115,146],"are":[117,139,163,202,221],"discovered":[119],"according":[120],"node":[123],"importance":[124],"index,":[125],"then":[127],"PPI":[129],"network":[130],"is":[131,210],"divided":[132],"into":[133],"multiple":[134],"communities.":[135],"belonging":[142],"both":[144],"same":[153],"community,":[154],"regarded":[155],"as":[156,165],"groups.":[158],"Through":[159],"experiments,":[160],"10":[161],"identified":[164],"group.":[168],"Survival":[169],"analyses":[170],"group":[174],"show":[175],"only":[177],"PLK1,":[178],"CCNB1,":[179],"CDK1":[181],"participate":[182],"prognosis":[185],"relate":[189],"stage":[193],"LUAD.":[195,243,256],"These":[196],"demonstrate":[197],"three":[200,225,233],"extremely":[203],"cell":[207],"cycle,":[208],"which":[209,227],"confirmed":[211],"following":[214],"enrichment":[215],"analyses.":[216],"Besides,":[217],"significant":[219],"correlations":[220],"observed":[222],"among":[223],"provide":[228],"clue":[230],"cooperate":[236],"This":[244],"finding":[245],"provides":[246],"possible":[247],"clinical":[248],"targets":[249],"for":[250],"diagnosis":[252],"treatment":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}