{"id":"https://openalex.org/W3124802997","doi":"https://doi.org/10.1109/access.2021.3053839","title":"Principal Component Regression Analysis for lncRNA-Disease Association Prediction Based on Pathological Stage Data","display_name":"Principal Component Regression Analysis for lncRNA-Disease Association Prediction Based on Pathological Stage Data","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3124802997","doi":"https://doi.org/10.1109/access.2021.3053839","mag":"3124802997"},"language":"en","primary_location":{"id":"doi:10.1109/access.2021.3053839","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3053839","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09333608.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09333608.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102811806","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0002-4983-7288"},"institutions":[{"id":"https://openalex.org/I111971639","display_name":"Qiqihar University","ror":"https://ror.org/01khf5d59","country_code":"CN","type":"education","lineage":["https://openalex.org/I111971639"]},{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["College of Computer Science and Technology, Harbin Engineering University, Harbin, China","College of Computer and Control, Qiqihar University, Qiqihar, China"],"raw_orcid":"https://orcid.org/0000-0002-4983-7288","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Harbin Engineering University, Harbin, China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"College of Computer and Control, Qiqihar University, Qiqihar, China","institution_ids":["https://openalex.org/I111971639"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100757044","display_name":"Zhang Jing","orcid":"https://orcid.org/0000-0002-1846-9603"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]},{"id":"https://openalex.org/I34949971","display_name":"University of Jinan","ror":"https://ror.org/02mjz6f26","country_code":"CN","type":"education","lineage":["https://openalex.org/I34949971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["College of Computer Science and Technology, Harbin Engineering University, Harbin, China","School of Information Science and Engineering, University of Jinan, Jinan, China","Shandong Provincial Key Laboratory of Network-Based Intelligent Computing, Jinan, China"],"raw_orcid":"https://orcid.org/0000-0002-1846-9603","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Harbin Engineering University, Harbin, China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"School of Information Science and Engineering, University of Jinan, Jinan, China","institution_ids":["https://openalex.org/I34949971"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Network-Based Intelligent Computing, Jinan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.2376,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40505811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":null,"first_page":"20629","last_page":"20640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9261000156402588,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6326346397399902},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46163296699523926},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.41554513573646545},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4138849675655365},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4106561243534088},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3930402994155884},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3325159251689911},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.31233906745910645},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24341651797294617},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.20513179898262024},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19149592518806458},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1483079493045807},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13354694843292236}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6326346397399902},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46163296699523926},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41554513573646545},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4138849675655365},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4106561243534088},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3930402994155884},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3325159251689911},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31233906745910645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24341651797294617},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20513179898262024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19149592518806458},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1483079493045807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13354694843292236}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2021.3053839","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3053839","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09333608.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5353df7089f04d16aa8326bcf69117c0","is_oa":true,"landing_page_url":"https://doaj.org/article/5353df7089f04d16aa8326bcf69117c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 9, Pp 20629-20640 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2021.3053839","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2021.3053839","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/9312710/09333608.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2356155875","display_name":"\u91ce\u845b\u82b1\u548c\u67b8\u9aa8\u53f6\u4e2d\u7684\u5316\u5b66\u6210\u5206\u548c\u90e8\u5206\u751f\u7406\u6d3b\u6027\u7814\u7a76","funder_award_id":"20172020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3199199904","display_name":null,"funder_award_id":"2020\u20132022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3737690122","display_name":null,"funder_award_id":"(2020\u20132022, No. ZR2019LZH005)","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G6784270870","display_name":null,"funder_award_id":"51679058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7862427978","display_name":null,"funder_award_id":"(2017-2020, No. 51679058)","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124802997.pdf","grobid_xml":"https://content.openalex.org/works/W3124802997.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1158178075","https://openalex.org/W1999956264","https://openalex.org/W2118260473","https://openalex.org/W2130388134","https://openalex.org/W2512308096","https://openalex.org/W2531500048","https://openalex.org/W2795930824","https://openalex.org/W2797648991","https://openalex.org/W2799521572","https://openalex.org/W2801972999","https://openalex.org/W2880850155","https://openalex.org/W2882221922","https://openalex.org/W2886819263","https://openalex.org/W2893418727","https://openalex.org/W2894088602","https://openalex.org/W2896968586","https://openalex.org/W2901420601","https://openalex.org/W2904010148","https://openalex.org/W2922395812","https://openalex.org/W2939729313","https://openalex.org/W2943167119","https://openalex.org/W2952153265","https://openalex.org/W2961565435","https://openalex.org/W2967521176","https://openalex.org/W2969832535","https://openalex.org/W2990143159","https://openalex.org/W2991682949","https://openalex.org/W3006402852","https://openalex.org/W3006845127","https://openalex.org/W3011704994","https://openalex.org/W3013787003","https://openalex.org/W3014170703","https://openalex.org/W3020929333","https://openalex.org/W3023899890","https://openalex.org/W3028590990","https://openalex.org/W3032024579","https://openalex.org/W3039195968","https://openalex.org/W3042454808","https://openalex.org/W3046478612","https://openalex.org/W3097173659"],"related_works":["https://openalex.org/W1975632186","https://openalex.org/W3027745756","https://openalex.org/W3205213561","https://openalex.org/W2531880140","https://openalex.org/W2036609560","https://openalex.org/W346861917","https://openalex.org/W3024018414","https://openalex.org/W2126145365","https://openalex.org/W4380081032","https://openalex.org/W1542592062"],"abstract_inverted_index":{"Accumulating":[0],"researches":[1,50],"have":[2,37],"found":[3],"that":[4,199],"lncRNAs":[5,24],"play":[6,25],"a":[7,220],"key":[8],"role":[9,28],"in":[10,29,90],"many":[11,33],"important":[12,27,34],"biological":[13],"processes,":[14],"such":[15],"as":[16,61],"chromatin":[17],"modification,":[18],"transcription,":[19],"and":[20,43,66,138,174,208],"post-transcription":[21],"regulation.":[22],"Because":[23],"an":[26],"the":[30,41,58,77,82,100,123,142,145,192,211],"life":[31],"process,":[32],"complex":[35],"diseases":[36],"been":[38],"linked":[39],"to":[40],"variation":[42],"dysfunction":[44],"of":[45,57,127,144,210,228],"lncRNAs.":[46],"In":[47,72],"current":[48],"prediction":[49,152,175,181,212,226],"on":[51,107,136,141,158,185],"lncRNA-disease":[52,83,155,188,229],"association,":[53],"clinical":[54,64],"prognosis":[55],"information":[56],"disease":[59],"(such":[60],"pathological":[62,78,132,150,193],"stage,":[63],"stage":[65,79,133,151,194],"so":[67],"on)":[68],"is":[69,93,114,164,183],"rarely":[70],"mentioned.":[71],"this":[73],"manuscript,":[74],"we":[75],"apply":[76],"data":[80],"into":[81],"association":[84,156,189],"prediction.":[85],"Firstly,":[86],"coordinates":[87],"reverse":[88],"rotation":[89],"circular":[91],"(CRRC)":[92],"proposed.":[94],"6":[95],"clusters":[96],"are":[97,120,177,214],"calculated":[98],"by":[99,122,216],"proposed":[101,124,180],"cluster":[102],"generating":[103],"algorithm":[104,126,153],"(ClGeA)":[105],"based":[106,135,157,184],"CRRC.":[108],"Secondly,":[109],"harmonic":[110],"importance":[111],"ranking":[112],"(HIR)":[113],"put":[115],"forward.":[116],"28":[117,147],"core":[118,128,148],"variables":[119,129],"obtained":[121],"selection":[125],"for":[130,154,202,224],"cancer":[131],"(SA-CV-CPS)":[134],"HIR":[137],"cluster.":[139],"Finally,":[140],"basis":[143],"above":[146],"variables,":[149],"principal":[159,168],"component":[160,169],"regression":[161],"analysis":[162],"(PSPA-LA-PCRA)":[163],"developed.":[165],"Through":[166],"PSPA-LA-PCRA,":[167,217],"set":[170],"(including":[171],"20":[172],"PCs)":[173],"model":[176,182,213],"gained.":[178],"The":[179],"unknown":[186],"human":[187],"combining":[190],"with":[191],"data.":[195],"Experimental":[196],"results":[197,201],"show":[198],"better":[200],"AUC,":[203],"precision":[204],"rate,":[205],"recall":[206],"rate":[207],"F1-score":[209],"achieved":[215],"which":[218],"provides":[219],"favorable":[221],"research":[222],"premise":[223],"subsequent":[225],"studies":[227],"associations.":[230]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}