{"id":"https://openalex.org/W3047493013","doi":"https://doi.org/10.1109/access.2020.3014339","title":"Enhanced CEST MRI Using the Residual of Inversed Z-Spectra for Ischemia Detection","display_name":"Enhanced CEST MRI Using the Residual of Inversed Z-Spectra for Ischemia Detection","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3047493013","doi":"https://doi.org/10.1109/access.2020.3014339","mag":"3047493013"},"language":"it","primary_location":{"id":"doi:10.1109/access.2020.3014339","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3014339","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09159550.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09159550.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100705837","display_name":"Lihong Zhang","orcid":"https://orcid.org/0000-0003-2946-8072"},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihong Zhang","raw_affiliation_strings":["School of Information Science and Technology, Northwest University, Xi\u2019an, China","School of Information Science and Technology, Northwest University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi\u2019an, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi'an, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486420","display_name":"Yuhua Liang","orcid":"https://orcid.org/0000-0002-2970-5595"},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Liang","raw_affiliation_strings":["School of Information Science and Technology, Northwest University, Xi\u2019an, China","School of Information Science and Technology, Northwest University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0002-2970-5595","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi\u2019an, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi'an, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101973215","display_name":"Yanrong Chen","orcid":"https://orcid.org/0000-0002-0940-5448"},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanrong Chen","raw_affiliation_strings":["School of Information Science and Technology, Northwest University, Xi\u2019an, China","School of Information Science and Technology, Northwest University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0002-0940-5448","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi\u2019an, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi'an, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064516205","display_name":"Guangzu Li","orcid":"https://orcid.org/0000-0003-0494-1732"},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangzu Li","raw_affiliation_strings":["Department of Medical Imaging, Weifang Medical University, Weifang, China"],"raw_orcid":"https://orcid.org/0000-0003-0494-1732","affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029026545","display_name":"Mengbei Zhang","orcid":"https://orcid.org/0000-0003-0946-6627"},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengbei Zhang","raw_affiliation_strings":["Department of Medical Imaging, Weifang Medical University, Weifang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102829690","display_name":"Yingcheng Zhao","orcid":"https://orcid.org/0000-0003-4177-0936"},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingcheng Zhao","raw_affiliation_strings":["School of Information Science and Technology, Northwest University, Xi\u2019an, China","School of Information Science and Technology, Northwest University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0003-4177-0936","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi\u2019an, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi'an, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456927","display_name":"Xiaoli Wang","orcid":"https://orcid.org/0000-0003-3334-6713"},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Wang","raw_affiliation_strings":["Department of Medical Imaging, Weifang Medical University, Weifang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090414812","display_name":"Xiaolei Song","orcid":"https://orcid.org/0000-0002-0206-1574"},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Song","raw_affiliation_strings":["School of Information Science and Technology, Northwest University, Xi\u2019an, China","School of Information Science and Technology, Northwest University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0002-0206-1574","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi\u2019an, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Information Science and Technology, Northwest University, Xi'an, China","institution_ids":["https://openalex.org/I37802460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.2918,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44745875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"8","issue":null,"first_page":"147323","last_page":"147336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/residual","display_name":"Residual","score":0.5772845149040222},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3851131200790405},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.3769064247608185},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33351701498031616},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.33340299129486084},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.30906426906585693}],"concepts":[{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.5772845149040222},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3851131200790405},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3769064247608185},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33351701498031616},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.33340299129486084},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30906426906585693}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2020.3014339","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3014339","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09159550.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5e722bdca5f8463288f80afcd8eee493","is_oa":true,"landing_page_url":"https://doaj.org/article/5e722bdca5f8463288f80afcd8eee493","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 8, Pp 147323-147336 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2020.3014339","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3014339","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09159550.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4702568265","display_name":"\u8110\u8840\u5355\u4e2a\u6838\u7ec6\u80de\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u589e\u6b96\u4e0e\u5206\u5316\u53ca\u5176\u673a\u5236\u7814\u7a76","funder_award_id":"81000268","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5780213017","display_name":null,"funder_award_id":"61601364","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047493013.pdf","grobid_xml":"https://content.openalex.org/works/W3047493013.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482675544","https://openalex.org/W1510063841","https://openalex.org/W1564236750","https://openalex.org/W1782573808","https://openalex.org/W1901471451","https://openalex.org/W1969935384","https://openalex.org/W2003126239","https://openalex.org/W2003572429","https://openalex.org/W2004807822","https://openalex.org/W2012678826","https://openalex.org/W2046232440","https://openalex.org/W2064588148","https://openalex.org/W2070231190","https://openalex.org/W2070825671","https://openalex.org/W2074136578","https://openalex.org/W2160826774","https://openalex.org/W2363367799","https://openalex.org/W2398802375","https://openalex.org/W2471422179","https://openalex.org/W2592787056","https://openalex.org/W2593499406","https://openalex.org/W2605468160","https://openalex.org/W2736968733","https://openalex.org/W2791053375","https://openalex.org/W2886062597","https://openalex.org/W2886159082","https://openalex.org/W2914463475","https://openalex.org/W2941518589","https://openalex.org/W2951642982","https://openalex.org/W2963834324","https://openalex.org/W2982244275","https://openalex.org/W4239230441"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W3084825885","https://openalex.org/W2298861036","https://openalex.org/W2271181815"],"abstract_inverted_index":{"Chemical":[0],"exchange":[1,73,107],"saturation":[2],"transfer":[3],"(CEST)":[4],"magnetic":[5],"resonance":[6],"imaging":[7],"(MRI)":[8],"had":[9],"shown":[10],"potential":[11],"in":[12,19,117,173,184,223,278],"sensing":[13],"pH":[14,79,231],"changes":[15,149,193],"that":[16],"occurs":[17],"early":[18],"ischemic":[20],"stroke.":[21],"However,":[22],"detection":[23,33,293],"of":[24,44,62,75,171],"mild":[25],"acidosis":[26],"is":[27],"still":[28],"challenging.":[29],"To":[30],"enhance":[31,291],"CEST":[32,292],"for":[34,189,294],"ischemia,":[35],"we":[36],"proposed":[37],"a":[38,168],"quantification":[39,84],"approach":[40],"using":[41,56,139],"the":[42,51,95,101,105,174,180,203,211,227,264,268,273,279],"residual":[43,92],"inversed":[45],"Z-spectra,":[46],"i.e.":[47],"MTRRexVOPVP=":[48],"1/Zexp-1/Zref,":[49],"where":[50],"reference":[52],"Z-spectra":[53,132,236],"Zrefwas":[54],"calculated":[55],"our":[57],"previously":[58],"developed":[59],"Voxel-wise":[60],"Optimization":[61],"Pseudo":[63],"Voigt":[64],"Profile":[65],"(VOPVP).":[66],"Simulations":[67],"were":[68,134],"performed":[69,113],"at":[70,114,120,136,282],"two":[71,106,259,269],"different":[72,78],"rates":[74],"amide,":[76,214],"representing":[77],"values.":[80],"Among":[81,198],"all":[82,161,199,254],"tested":[83,200],"methods,":[85,201],"including":[86],"MTRasym,":[87],"Lorentzian":[88],"Difference":[89],"(LD),":[90],"VOPVP":[91],"(ZVOPVP":[93],"residual),":[94],"analytical":[96],"solution":[97],"and":[98,144,153,210,216,237,251,261,275],"MTRRexOPVP,":[99],"MTRRexVOPVPexhibited":[100],"largest":[102,265],"difference":[103],"between":[104,150,207,258,267],"rates.":[108],"In":[109,177,288],"vivo":[110],"CEST-MRI":[111],"was":[112],"7":[115],"Tesla":[116],"rat":[118],"brain,":[119],"2":[121,283],"hours":[122,284],"after":[123],"transient":[124,286],"ischemia":[125],"by":[126],"middle":[127],"cerebral":[128],"artery":[129],"occlusion.":[130],"Firstly,":[131],"images":[133],"assessed":[135],"multiple":[137],"offsets":[138],"histogram":[140],"analysis,":[141],"with":[142,191,232],"3.5":[143],"-3.5":[145],"ppm":[146],"exhibiting":[147],"significant":[148,220],"normal":[151],"rats":[152,155,190],"stroke":[154,162],"(n":[156],"=":[157],"5":[158],"each).":[159],"For":[160,213],"rats,":[163],"MTRRexVOPVPimages":[164],"(3.5":[165],"ppm)":[166],"exhibited":[167],"large":[169],"area":[170],"hypointensity":[172],"lesion":[175,208],"hemisphere.":[176,270],"contrast,":[178],"MTRasymand":[179],"three-offsets":[181],"method":[182],"failed":[183],"detecting":[185],"such":[186,243],"changes,":[187],"particularly":[188],"little":[192],"on":[194],"T2wand":[195],"DWI":[196],"images.":[197],"MTRRexVOPVPachieved":[202],"highest":[204],"contrast-to-noise":[205],"ratio":[206],"striatum":[209],"contralateral.":[212],"amine":[215],"NOE,":[217],"ZresidualVOPVPand":[218],"MTRRexVOPVPshowed":[219],"reduced":[221],"signals":[222],"lesions":[224],"compared":[225],"to":[226],"contralateral,":[228],"indicating":[229],"lower":[230],"slower":[233],"exchange.":[234],"But":[235],"MTRasym":[238],"signal":[239],"did":[240],"not":[241],"show":[242,263],"difference.":[244],"At":[245],"later":[246],"time":[247],"points":[248],"(6":[249],"hrs":[250],"24":[252],"hrs),":[253],"methods":[255],"displayed":[256],"contrast":[257,266],"hemispheres":[260],"MTRRexVOPVPstill":[262],"Histology":[271],"confirmed":[272],"edema":[274],"other":[276],"damage":[277],"ipsilateral":[280],"hemisphere":[281],"post":[285],"ischemia.":[287,295],"summary,":[289],"MTRRexVOPVPmay":[290]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
