{"id":"https://openalex.org/W3043382267","doi":"https://doi.org/10.1109/access.2020.3008750","title":"A Genotype-Based Ensemble Classifier System for Non-Small-Cell Lung Cancer","display_name":"A Genotype-Based Ensemble Classifier System for Non-Small-Cell Lung Cancer","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3043382267","doi":"https://doi.org/10.1109/access.2020.3008750","mag":"3043382267"},"language":"en","primary_location":{"id":"doi:10.1109/access.2020.3008750","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3008750","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09139244.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09139244.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083949767","display_name":"Yanqiong Ren","orcid":"https://orcid.org/0000-0002-7619-1400"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yanqiong Ren","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China"],"raw_orcid":"https://orcid.org/0000-0002-7619-1400","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085127108","display_name":"Ziyi Yang","orcid":"https://orcid.org/0000-0002-3550-9283"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Zi-Yi Yang","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China"],"raw_orcid":"https://orcid.org/0000-0002-3550-9283","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323532","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0003-1715-4332"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China"],"raw_orcid":"https://orcid.org/0000-0003-1715-4332","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083841358","display_name":"Yong Liang","orcid":"https://orcid.org/0000-0002-2858-2810"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yong Liang","raw_affiliation_strings":["Faculty of Information Technology and Collaborative Laboratory for Intelligent Science and Systems, Macau University of Science and Technology, Macau, China","Guangdong-Hong Kong-Macao Joint Laboratory for Smart Discrete Manufacturing, Guangzhou, China","State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China"],"raw_orcid":"https://orcid.org/0000-0002-2858-2810","affiliations":[{"raw_affiliation_string":"Faculty of Information Technology and Collaborative Laboratory for Intelligent Science and Systems, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]},{"raw_affiliation_string":"Guangdong-Hong Kong-Macao Joint Laboratory for Smart Discrete Manufacturing, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040705853","display_name":"Haihui Huang","orcid":"https://orcid.org/0000-0002-6546-969X"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Hai-Hui Huang","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China"],"raw_orcid":"https://orcid.org/0000-0002-6546-969X","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101684380","display_name":"Hua Chai","orcid":"https://orcid.org/0000-0001-8354-3948"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Chai","raw_affiliation_strings":["School of Data and Computer Science, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-8354-3948","affiliations":[{"raw_affiliation_string":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0814,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4349718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":null,"first_page":"128509","last_page":"128518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.6808518767356873},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.5723971724510193},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.523207426071167},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5225836038589478},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49187159538269043},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.4674708843231201},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.4253963530063629},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37414222955703735},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.37371623516082764},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3288177251815796},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2827959954738617},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1481383740901947},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.14283820986747742},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13364040851593018},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13240495324134827},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.09517532587051392}],"concepts":[{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.6808518767356873},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5723971724510193},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.523207426071167},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5225836038589478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49187159538269043},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4674708843231201},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4253963530063629},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37414222955703735},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37371623516082764},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3288177251815796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2827959954738617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1481383740901947},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.14283820986747742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13364040851593018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13240495324134827},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.09517532587051392}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2020.3008750","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3008750","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09139244.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f1ce184d1d43434aa992c3bd50153dc6","is_oa":true,"landing_page_url":"https://doaj.org/article/f1ce184d1d43434aa992c3bd50153dc6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 8, Pp 128509-128518 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2020.3008750","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.3008750","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09139244.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043382267.pdf","grobid_xml":"https://content.openalex.org/works/W3043382267.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1498673086","https://openalex.org/W1676117227","https://openalex.org/W1973543655","https://openalex.org/W1977301516","https://openalex.org/W2001710803","https://openalex.org/W2004199685","https://openalex.org/W2024311320","https://openalex.org/W2029446677","https://openalex.org/W2033582154","https://openalex.org/W2034150340","https://openalex.org/W2034260606","https://openalex.org/W2044545697","https://openalex.org/W2046759180","https://openalex.org/W2047004048","https://openalex.org/W2049484790","https://openalex.org/W2113687561","https://openalex.org/W2114843025","https://openalex.org/W2118423420","https://openalex.org/W2120261416","https://openalex.org/W2121389354","https://openalex.org/W2128696591","https://openalex.org/W2129659619","https://openalex.org/W2143367532","https://openalex.org/W2146096861","https://openalex.org/W2148423395","https://openalex.org/W2149441684","https://openalex.org/W2169332099","https://openalex.org/W2176372762","https://openalex.org/W2289683153","https://openalex.org/W2327437619","https://openalex.org/W2557577055","https://openalex.org/W2602300053","https://openalex.org/W2734770034","https://openalex.org/W2746791238","https://openalex.org/W2762794689","https://openalex.org/W2782237096","https://openalex.org/W2797166305","https://openalex.org/W2953901678","https://openalex.org/W2956135855","https://openalex.org/W2963243933","https://openalex.org/W2964986834","https://openalex.org/W2973418100","https://openalex.org/W3105340263"],"related_works":["https://openalex.org/W2134373856","https://openalex.org/W2385665726","https://openalex.org/W2347271704","https://openalex.org/W2391157579","https://openalex.org/W3029453589","https://openalex.org/W2036624756","https://openalex.org/W2096545705","https://openalex.org/W2372977423","https://openalex.org/W2393901146","https://openalex.org/W1979229300"],"abstract_inverted_index":{"The":[0,93,118,143],"heterogeneity":[1,12,157],"of":[2,7,20,79,84,91,96,116,120,138,141,158],"cancer":[3],"reflects":[4],"the":[5,11,18,47,82,88,105,129,136,156],"complexity":[6],"genetic":[8,89,139],"mutations.":[9],"Dissecting":[10],"plays":[13],"an":[14],"important":[15],"role":[16],"in":[17,36,135],"field":[19],"biomarker":[21],"discovery,":[22],"targeted":[23],"therapy":[24],"and":[25,86,123],"drug":[26],"designing.":[27],"As":[28],"it":[29],"is":[30,72,98,110],"time-consuming":[31],"to":[32,59,76,99],"identify":[33,87],"new":[34],"biomarkers":[35],"biological":[37],"experiments,":[38],"various":[39],"machine":[40],"learning":[41],"methods":[42,49],"have":[43],"been":[44],"developed.":[45],"However,":[46],"current":[48],"are":[50],"limited":[51],"because":[52],"they":[53],"ignore":[54],"that":[55,107,128],"patients":[56],"may":[57],"correspond":[58],"different":[60],"disease-causing":[61],"genotypes.":[62],"In":[63],"this":[64],"article,":[65],"a":[66,147],"genotype-based":[67],"ensemble":[68],"classifier":[69,109],"system":[70],"(GECS)":[71],"proposed":[73,130],"which":[74],"aims":[75],"explain":[77],"pathologies":[78],"NSCLC":[80],"from":[81],"view":[83],"genotypes":[85],"subtypes":[90,140],"tumors.":[92,142],"core":[94],"strategy":[95],"GECS":[97,144],"construct":[100],"multiple":[101],"independent":[102],"classifiers":[103],"following":[104],"principle":[106],"one":[108,114],"constructed":[111],"based":[112],"on":[113],"genotype":[115],"NSCLC.":[117],"analysis":[119],"synthetic":[121],"data":[122],"three":[124],"microarray":[125],"datasets":[126],"indicated":[127],"method":[131,145],"outperforms":[132],"existing":[133],"approaches":[134],"identification":[137],"provides":[146],"useful":[148],"tool":[149],"for":[150,154],"molecular":[151],"pathology":[152],"researches":[153],"dissecting":[155],"cancer.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
