{"id":"https://openalex.org/W3025844038","doi":"https://doi.org/10.1109/access.2020.2994217","title":"A Programmable EEG Monitoring SoC with Optical and Electrical Stimulation for Epilepsy Control","display_name":"A Programmable EEG Monitoring SoC with Optical and Electrical Stimulation for Epilepsy Control","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3025844038","doi":"https://doi.org/10.1109/access.2020.2994217","mag":"3025844038"},"language":"en","primary_location":{"id":"doi:10.1109/access.2020.2994217","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2994217","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09091806.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09091806.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015308343","display_name":"Shuenn-Yuh Lee","orcid":"https://orcid.org/0000-0002-9757-1410"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shuenn-Yuh Lee","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008313540","display_name":"Chieh Tsou","orcid":"https://orcid.org/0000-0002-8038-8943"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chieh Tsou","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049967171","display_name":"Zhan-Xian Liao","orcid":"https://orcid.org/0000-0003-1792-3795"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Zhan-Xian Liao","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091741148","display_name":"Po-Hao Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Hao Cheng","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014731743","display_name":"Peng-Wei Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Peng-Wei Huang","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029568582","display_name":"Hao-Yun Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hao-Yun Lee","raw_affiliation_strings":["National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059210875","display_name":"Chou\u2010Ching K. Lin","orcid":"https://orcid.org/0000-0002-3070-5787"},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chou-Ching Lin","raw_affiliation_strings":["Division of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012426253","display_name":"Gia-Shing Shieh","orcid":"https://orcid.org/0000-0003-2480-4313"},"institutions":[{"id":"https://openalex.org/I4210138942","display_name":"Chest Hospital, Ministry of Health and Welfare","ror":"https://ror.org/03s4kpx37","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210138942"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Gia-Shing Shieh","raw_affiliation_strings":["College of Medicine, National Cheng Kung University, Tainan, Taiwan","Division of Urology, Ministry of Health and Welfare Tainan Hospital, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Division of Urology, Ministry of Health and Welfare Tainan Hospital, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210138942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5015308343"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.0388,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71608898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.6960712671279907},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6711633205413818},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5330770015716553},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4501129388809204},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2388416826725006},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1246800422668457}],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6960712671279907},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6711633205413818},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5330770015716553},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4501129388809204},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2388416826725006},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1246800422668457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2020.2994217","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2994217","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09091806.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c21a3f9245b54f479fd4da69594a3d68","is_oa":true,"landing_page_url":"https://doaj.org/article/c21a3f9245b54f479fd4da69594a3d68","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 8, Pp 92196-92211 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2020.2994217","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2994217","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09091806.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8100000023841858,"display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3025844038.pdf","grobid_xml":"https://content.openalex.org/works/W3025844038.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1524624671","https://openalex.org/W1965295889","https://openalex.org/W1973466749","https://openalex.org/W1980041945","https://openalex.org/W1985280311","https://openalex.org/W1986216475","https://openalex.org/W2023261684","https://openalex.org/W2031790846","https://openalex.org/W2034910693","https://openalex.org/W2039698130","https://openalex.org/W2040912879","https://openalex.org/W2073141334","https://openalex.org/W2073604663","https://openalex.org/W2076372975","https://openalex.org/W2077204677","https://openalex.org/W2083166398","https://openalex.org/W2086162264","https://openalex.org/W2102244548","https://openalex.org/W2103991643","https://openalex.org/W2116967153","https://openalex.org/W2122982148","https://openalex.org/W2135629133","https://openalex.org/W2147032036","https://openalex.org/W2147555064","https://openalex.org/W2152945888","https://openalex.org/W2156677329","https://openalex.org/W2162369617","https://openalex.org/W2167237768","https://openalex.org/W2169880831","https://openalex.org/W2470469249","https://openalex.org/W2575060568","https://openalex.org/W2733944823","https://openalex.org/W2743906340","https://openalex.org/W2751360732","https://openalex.org/W2789599343","https://openalex.org/W2793986881","https://openalex.org/W2802248155","https://openalex.org/W2807317053","https://openalex.org/W2884691162","https://openalex.org/W2890191974","https://openalex.org/W2896520547","https://openalex.org/W2899003573","https://openalex.org/W2916363139","https://openalex.org/W2921334273","https://openalex.org/W2922085882","https://openalex.org/W2922470221","https://openalex.org/W2945449319","https://openalex.org/W2966038323","https://openalex.org/W4233394827","https://openalex.org/W7007710855"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2395385109","https://openalex.org/W2773633178","https://openalex.org/W2080101436","https://openalex.org/W2802335767","https://openalex.org/W2922348724","https://openalex.org/W2356350882","https://openalex.org/W4388090985","https://openalex.org/W200322357","https://openalex.org/W2390279801"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"a":[3,9,14,29,73,86,89,117,165,205,217,240],"cross-domain":[4],"integration":[5],"system":[6,61],"composed":[7,66],"of":[8,67,101,113,150,156,183,192,211],"gene":[10,43,233],"transfer":[11,36,44,234],"technique":[12],"with":[13,24,46,53,72,88,107,116,139,164,231],"pre-clinical":[15],"trial,":[16],"an":[17,21,81,93],"on-chip":[18],"circuit":[19,224],"design,":[20],"off-chip":[22],"hardware":[23],"peripheral":[25],"unit":[26,84],"integration,":[27],"and":[28,92,131,153,174,180,190,198,249],"custom":[30,241],"software":[31,242],"is":[32,37,65,104,121,162,229,244],"presented.":[33],"Opsin":[34],"protein-gene":[35],"successfully":[38],"conducted":[39],"to":[40,76,146,246],"demonstrate":[41],"that":[42],"treatment":[45],"optical":[47,157],"stimulation":[48,152],"has":[49],"several":[50],"benefits":[51],"compared":[52],"electrical":[54,151],"treatment.":[55],"The":[56,97,111,125,137,159,226],"proposed":[57,160],"wireless":[58],"programmable":[59],"stimulating":[60],"on":[62,142],"chip":[63],"(WPSSoC)":[64],"two":[68],"sensing":[69],"channels":[70],"combined":[71],"decimation":[74],"filter":[75],"acquire":[77],"intracranial":[78],"electroencephalography":[79],"(iEEG),":[80],"epilepsy":[82],"detection":[83],"(EDU),":[85],"stimulator":[87,138],"waveform":[90],"controller,":[91],"ultra-low-power":[94],"embedded":[95],"transceiver.":[96],"equivalent":[98],"sample":[99],"rate":[100],"sensed":[102],"data":[103],"375":[105],"samples/s":[106],"16-bit":[108],"output":[109],"data.":[110],"performance":[112],"intermodulation":[114],"distortion":[115],"third":[118],"order":[119],"(IMD3)":[120],"approximately":[122],"68":[123],"dB.":[124],"EDU":[126],"extracts":[127],"approximate":[128],"entropy":[129],"(ApEn)":[130],"spectrum":[132],"bins":[133],"for":[134],"the":[135,143],"classifier.":[136],"controller":[140],"features":[141],"waveform-adjustable":[144],"function":[145],"provide":[147,247],"0-510":[148],"\u03bcA":[149],"0-50":[154],"mW":[155,197],"stimulation.":[158],"transceiver":[161],"implemented":[163],"2.45":[166],"GHz":[167],"on-off":[168],"keying":[169],"(OOK)":[170],"carrier":[171],"frequency.":[172],"Transmitter":[173],"receiver":[175],"front-ends":[176],"perform":[177],"at":[178],"50.6":[179],"12.7":[181],"pJ/bit":[182],"energy":[184],"per":[185],"bit,":[186],"respectively.":[187,209],"Power":[188],"consumption":[189],"area":[191],"WPSSoC":[193],"are":[194,214],"about":[195],"1":[196],"13.67":[199],"mm":[200],"<sup":[201],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[202],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[203],"in":[204,216,235],"0.18":[206],"\u03bcm":[207],"process,":[208],"Circuits":[210],"each":[212],"part":[213],"integrated":[215],"4.3":[218],"cm":[219,222],"\u00d7":[220],"2":[221],"printed":[223],"board.":[225],"shrunk":[227],"device":[228],"verified":[230],"Thy1-ChR2-YFP":[232],"C57BL/6":[236],"mice":[237],"by":[238],"using":[239],"which":[243],"used":[245],"commands":[248],"monitor":[250],"iEEG.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}