{"id":"https://openalex.org/W3022729412","doi":"https://doi.org/10.1109/access.2020.2992672","title":"PCSPred_SC: Prediction of Protein Citrullination Sites Using an Effective Sequence-Based Combined Method","display_name":"PCSPred_SC: Prediction of Protein Citrullination Sites Using an Effective Sequence-Based Combined Method","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3022729412","doi":"https://doi.org/10.1109/access.2020.2992672","mag":"3022729412"},"language":"en","primary_location":{"id":"doi:10.1109/access.2020.2992672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2992672","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09087882.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09087882.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107410504","display_name":"L\u00edna Zhang","orcid":"https://orcid.org/0000-0003-3671-8690"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210158823","display_name":"Weihai Science and Technology Bureau","ror":"https://ror.org/05mx4xx46","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210158823"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lina Zhang","raw_affiliation_strings":["School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China","institution_ids":["https://openalex.org/I4210158823","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079955169","display_name":"Jin\u2010Gui Chen","orcid":"https://orcid.org/0000-0002-1752-4201"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210158823","display_name":"Weihai Science and Technology Bureau","ror":"https://ror.org/05mx4xx46","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210158823"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingui Chen","raw_affiliation_strings":["School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China","institution_ids":["https://openalex.org/I4210158823","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084281207","display_name":"Chengjin Zhang","orcid":"https://orcid.org/0000-0002-0066-2114"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210158823","display_name":"Weihai Science and Technology Bureau","ror":"https://ror.org/05mx4xx46","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210158823"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengjin Zhang","raw_affiliation_strings":["School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China","institution_ids":["https://openalex.org/I4210158823","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023736025","display_name":"Rui Gao","orcid":"https://orcid.org/0000-0002-3599-7678"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Gao","raw_affiliation_strings":["School of Control Science and Engineering, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Control Science and Engineering, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100693480","display_name":"Runtao Yang","orcid":"https://orcid.org/0000-0001-7542-1692"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210158823","display_name":"Weihai Science and Technology Bureau","ror":"https://ror.org/05mx4xx46","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210158823"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runtao Yang","raw_affiliation_strings":["School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China"],"raw_orcid":"https://orcid.org/0000-0001-7542-1692","affiliations":[{"raw_affiliation_string":"School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Weihai, China","institution_ids":["https://openalex.org/I4210158823","https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5107410504"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210158823"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.1667,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49356652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":95},"biblio":{"volume":"8","issue":null,"first_page":"88453","last_page":"88463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9821000099182129,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9509000182151794,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrullination","display_name":"Citrullination","score":0.7633009552955627},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7123839855194092},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6934899687767029},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6295437216758728},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4994773864746094},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4798116981983185},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.4556567668914795},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44667455554008484},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4394069314002991},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3414609432220459},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3344368040561676},{"id":"https://openalex.org/keywords/citrulline","display_name":"Citrulline","score":0.1365966796875},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11942082643508911}],"concepts":[{"id":"https://openalex.org/C48632299","wikidata":"https://www.wikidata.org/wiki/Q68581","display_name":"Citrullination","level":5,"score":0.7633009552955627},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7123839855194092},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6934899687767029},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6295437216758728},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4994773864746094},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4798116981983185},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.4556567668914795},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44667455554008484},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4394069314002991},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3414609432220459},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3344368040561676},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.1365966796875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11942082643508911},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2020.2992672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2992672","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09087882.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b7debe0b2e464fd5b938721fad4f7819","is_oa":true,"landing_page_url":"https://doaj.org/article/b7debe0b2e464fd5b938721fad4f7819","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 8, Pp 88453-88463 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2020.2992672","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2992672","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09087882.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1973267165","display_name":null,"funder_award_id":"61533011","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3570930218","display_name":null,"funder_award_id":"61603214","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3962627399","display_name":null,"funder_award_id":"U1806202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4612968745","display_name":null,"funder_award_id":"2018M630778","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6194174505","display_name":null,"funder_award_id":"61533011","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7535987406","display_name":null,"funder_award_id":"61573213","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8932005972","display_name":null,"funder_award_id":"61573213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G915367209","display_name":null,"funder_award_id":"61673245","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3022729412.pdf","grobid_xml":"https://content.openalex.org/works/W3022729412.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1532675490","https://openalex.org/W1537797133","https://openalex.org/W1981955336","https://openalex.org/W1985820548","https://openalex.org/W2034070267","https://openalex.org/W2037819382","https://openalex.org/W2040352648","https://openalex.org/W2063692638","https://openalex.org/W2081509574","https://openalex.org/W2082562176","https://openalex.org/W2093114687","https://openalex.org/W2104933073","https://openalex.org/W2122855193","https://openalex.org/W2123332832","https://openalex.org/W2129871852","https://openalex.org/W2132791018","https://openalex.org/W2148143831","https://openalex.org/W2153266668","https://openalex.org/W2156809104","https://openalex.org/W2160128879","https://openalex.org/W2168508521","https://openalex.org/W2217407338","https://openalex.org/W2257056231","https://openalex.org/W2338415548","https://openalex.org/W2423999230","https://openalex.org/W2488096231","https://openalex.org/W2516790083","https://openalex.org/W2538353315","https://openalex.org/W2569439418","https://openalex.org/W2600424538","https://openalex.org/W2611792444","https://openalex.org/W2618886090","https://openalex.org/W2622859518","https://openalex.org/W2748550961","https://openalex.org/W2749467817","https://openalex.org/W2754914719","https://openalex.org/W2763581042","https://openalex.org/W2765783049","https://openalex.org/W2772497662","https://openalex.org/W2773563175","https://openalex.org/W2783162988","https://openalex.org/W2783169536","https://openalex.org/W2783550932","https://openalex.org/W2784083480","https://openalex.org/W2790150162","https://openalex.org/W2791988510","https://openalex.org/W2793168264","https://openalex.org/W2793449375","https://openalex.org/W2794896638","https://openalex.org/W2795846614","https://openalex.org/W2800074215","https://openalex.org/W2804331675","https://openalex.org/W2810246703","https://openalex.org/W2884869637","https://openalex.org/W2885954425","https://openalex.org/W2886792527","https://openalex.org/W2904828342","https://openalex.org/W2911964244","https://openalex.org/W2946621368","https://openalex.org/W2958335087","https://openalex.org/W3124158594","https://openalex.org/W6675634716","https://openalex.org/W6679745481"],"related_works":["https://openalex.org/W2108980595","https://openalex.org/W2968257679","https://openalex.org/W4387235219","https://openalex.org/W1998890104","https://openalex.org/W2088104136","https://openalex.org/W2773563175","https://openalex.org/W2997694753","https://openalex.org/W2090751487","https://openalex.org/W4298148587","https://openalex.org/W1494243307"],"abstract_inverted_index":{"As":[0],"one":[1],"of":[2,14,22,28,52,55,96,150,175,197],"post-translational":[3],"modifications":[4],"(PTMs),":[5],"protein":[6,29,48],"citrullination":[7,30],"is":[8,33,183],"crucial":[9],"in":[10,19,131],"a":[11,20,63],"diverse":[12],"array":[13],"cellular":[15],"processes":[16],"and":[17,41,65,102,124,134,156],"implicated":[18],"slew":[21],"human":[23],"pathology.":[24],"Therefore,":[25],"accurate":[26],"identification":[27],"sites":[31],"(PCSs)":[32],"urgently":[34],"needed":[35],"to":[36,46,72,84,118,193],"illuminate":[37],"the":[38,42,47,53,56,75,90,93,113,120,125,138,148,168,173,186],"reaction":[39],"details":[40],"complex":[43],"pathogenesis":[44],"related":[45],"citrullination.":[49],"In":[50],"view":[51],"limitations":[54],"existing":[57],"PCS":[58],"predictors,":[59],"this":[60,179],"study":[61],"proposes":[62],"novel":[64],"powerful":[66],"sequence-based":[67],"combined":[68],"method":[69,188],"named":[70],"PCSPred_SC":[71,145],"further":[73],"enhance":[74],"prediction":[76,98],"performance.":[77],"Various":[78],"feature":[79,91,103,126],"extraction":[80],"methods":[81,105,115,128],"are":[82,106,116,129],"developed":[83],"mine":[85],"sequence-derived":[86],"biological":[87,199],"information.":[88],"Under":[89],"space,":[92],"predictive":[94],"capabilities":[95],"different":[97],"algorithms,":[99],"over-sampling":[100,114],"methods,":[101,170],"selection":[104,127],"respectively":[107],"explored.":[108],"Experimental":[109],"results":[110],"indicate":[111],"that":[112,185],"effective":[117],"solve":[119],"imbalanced":[121],"dataset":[122,140],"problem":[123],"significant":[130,191],"removing":[132],"irrelevant":[133],"redundant":[135],"features.":[136],"On":[137],"same":[139],"using":[141],"10-fold":[142],"cross":[143],"validation,":[144],"constructed":[146],"by":[147],"combination":[149],"support":[151],"vector":[152],"machine":[153],"(SVM),":[154],"Adasyn,":[155],"t-distributed":[157],"stochastic":[158],"neighbor":[159],"embedding":[160],"(t-SNE)":[161],"achieves":[162],"much":[163],"more":[164],"outstanding":[165],"performance":[166],"than":[167],"competing":[169],"while":[171],"reducing":[172],"number":[174],"features":[176],"used":[177],"for":[178],"task":[180],"remarkably.":[181],"It":[182],"anticipated":[184],"proposed":[187],"will":[189],"provide":[190],"information":[192],"broaden":[194],"our":[195],"knowledge":[196],"citrullination-related":[198],"processes.":[200]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2020-05-13T00:00:00"}
