{"id":"https://openalex.org/W3008067663","doi":"https://doi.org/10.1109/access.2020.2977108","title":"Fuzzy Logic System Application for Detecting SNP-SNP Interaction","display_name":"Fuzzy Logic System Application for Detecting SNP-SNP Interaction","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3008067663","doi":"https://doi.org/10.1109/access.2020.2977108","mag":"3008067663"},"language":"en","primary_location":{"id":"doi:10.1109/access.2020.2977108","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2977108","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09017977.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09017977.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065832977","display_name":"Cheng\u2010Hong Yang","orcid":"https://orcid.org/0000-0002-2741-0072"},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4387154394","display_name":"National Kaohsiung University of Science and Technology","ror":"https://ror.org/00hfj7g70","country_code":null,"type":"education","lineage":["https://openalex.org/I4387154394"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hong Yang","raw_affiliation_strings":["Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan","Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan","Ph. D. Program in Biomedical Engineering, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2741-0072","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4387154394"]},{"raw_affiliation_string":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Ph. D. Program in Biomedical Engineering, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034774683","display_name":"Li\u2010Yeh Chuang","orcid":"https://orcid.org/0000-0002-9817-5102"},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Yeh Chuang","raw_affiliation_strings":["Department of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan","Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I98298690"]},{"raw_affiliation_string":"Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068361665","display_name":"Yu\u2010Da Lin","orcid":"https://orcid.org/0000-0001-5100-6072"},"institutions":[{"id":"https://openalex.org/I4387154394","display_name":"National Kaohsiung University of Science and Technology","ror":"https://ror.org/00hfj7g70","country_code":null,"type":"education","lineage":["https://openalex.org/I4387154394"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Da Lin","raw_affiliation_strings":["Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4387154394"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.4806,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6703489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":null,"first_page":"49951","last_page":"49960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.6930993795394897},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6838802099227905},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.6519162058830261},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5658020973205566},{"id":"https://openalex.org/keywords/fuzzy-set","display_name":"Fuzzy set","score":0.5226380825042725},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.511031985282898},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48243483901023865},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.4815419316291809},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4475463628768921},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4468291699886322},{"id":"https://openalex.org/keywords/membership-function","display_name":"Membership function","score":0.4192139208316803},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.40178775787353516},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3656097650527954},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.33399519324302673},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.30779898166656494},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.2605489194393158},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13749250769615173},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1337953805923462}],"concepts":[{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.6930993795394897},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6838802099227905},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.6519162058830261},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5658020973205566},{"id":"https://openalex.org/C42011625","wikidata":"https://www.wikidata.org/wiki/Q1055058","display_name":"Fuzzy set","level":3,"score":0.5226380825042725},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.511031985282898},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48243483901023865},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4815419316291809},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4475463628768921},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4468291699886322},{"id":"https://openalex.org/C5263885","wikidata":"https://www.wikidata.org/wiki/Q1967302","display_name":"Membership function","level":4,"score":0.4192139208316803},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.40178775787353516},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3656097650527954},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33399519324302673},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30779898166656494},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2605489194393158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13749250769615173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1337953805923462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2020.2977108","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2977108","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09017977.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:bad6f8ca1c65458db0cc01cc689f0c78","is_oa":true,"landing_page_url":"https://doaj.org/article/bad6f8ca1c65458db0cc01cc689f0c78","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 8, Pp 49951-49960 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2020.2977108","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2020.2977108","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8948470/09017977.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1155323000","display_name":null,"funder_award_id":"108-2221-E-214-019-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G1852099315","display_name":null,"funder_award_id":"108-2811-E-992-502","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G37093097","display_name":null,"funder_award_id":"108-2221-E-992-031-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1571779206","https://openalex.org/W1717588182","https://openalex.org/W1822695366","https://openalex.org/W1974510435","https://openalex.org/W1993817351","https://openalex.org/W2012069179","https://openalex.org/W2016393220","https://openalex.org/W2041170649","https://openalex.org/W2043591360","https://openalex.org/W2063575312","https://openalex.org/W2085579219","https://openalex.org/W2089684487","https://openalex.org/W2104093114","https://openalex.org/W2118215201","https://openalex.org/W2119419044","https://openalex.org/W2122250592","https://openalex.org/W2126015874","https://openalex.org/W2126964466","https://openalex.org/W2134783591","https://openalex.org/W2136167691","https://openalex.org/W2141063866","https://openalex.org/W2150092391","https://openalex.org/W2152905639","https://openalex.org/W2153689210","https://openalex.org/W2154572047","https://openalex.org/W2155264882","https://openalex.org/W2155781289","https://openalex.org/W2167638767","https://openalex.org/W2426810552","https://openalex.org/W2504552073","https://openalex.org/W2510596894","https://openalex.org/W2526579808","https://openalex.org/W2600767115","https://openalex.org/W2605140612","https://openalex.org/W2766201984","https://openalex.org/W2785177491","https://openalex.org/W2790029186","https://openalex.org/W2800550692","https://openalex.org/W2803295257","https://openalex.org/W2883050039","https://openalex.org/W2884533157","https://openalex.org/W2887059233","https://openalex.org/W2895756362","https://openalex.org/W2899434347","https://openalex.org/W2908045104","https://openalex.org/W2912565176","https://openalex.org/W2999991510","https://openalex.org/W3151658902","https://openalex.org/W4211007335","https://openalex.org/W6756196682","https://openalex.org/W6772874008"],"related_works":["https://openalex.org/W3115968391","https://openalex.org/W2543073749","https://openalex.org/W2071860924","https://openalex.org/W283990522","https://openalex.org/W633389731","https://openalex.org/W2567343548","https://openalex.org/W2790029186","https://openalex.org/W3120769026","https://openalex.org/W2179307658","https://openalex.org/W2489911253"],"abstract_inverted_index":{"The":[0,211],"identification":[1],"of":[2,36,81,112,147,169,177,182,190],"interactions":[3,235,278],"between":[4,90],"single-nucleotide":[5],"polymorphisms":[6],"(SNP-SNP":[7],"interactions)":[8],"is":[9,41,125],"crucial":[10],"for":[11],"determining":[12,78],"human":[13],"genetic":[14],"disease":[15,239],"susceptibility.":[16],"With":[17],"rapid":[18],"technological":[19],"advancements,":[20],"multiobjective":[21],"multifactor":[22,119],"dimensionality":[23],"reduction":[24],"(MOMDR)":[25],"measurements":[26,156],"have":[27],"achieved":[28],"high":[29],"detection":[30,146,168,208],"success":[31,209],"rates.":[32],"However,":[33],"the":[34,79,88,91,100,109,122,133,144,148,167,175,178,188,247,268],"classification":[35,179],"high-":[37,113],"or":[38],"low-risk":[39,115],"groups":[40,116],"central":[42],"to":[43,48,107,127,198,201,207,275],"MOMDR":[44,105,183,220],"and":[45,94,97,114,184,216,261],"has":[46],"yet":[47],"be":[49,199,273],"extensively":[50],"studied.":[51],"To":[52],"address":[53],"limitations":[54],"in":[55,70,117,226,236,240,259],"binary":[56,215],"classification,":[57],"we":[58,195],"propose":[59],"an":[60],"improved":[61,84,101,134,269],"fuzzy":[62,217],"sigmoid":[63,270],"(FS)":[64],"approach":[65,86,103,136],"that":[66,214,264],"uses":[67],"membership":[68,110,130,265],"degrees":[69,111],"MOMDR,":[71],"thus":[72,142,165,262],"denoting":[73],"it":[74],"as":[75,279,281],"FSMOMDR.":[76],"For":[77],"interval":[80],"membership,":[82],"our":[83],"FS":[85,102,135],"assesses":[87],"distance":[89],"ithmultifactor":[92],"class":[93,120],"outcome":[95],"(cases":[96],"controls).":[98],"Thus,":[99,229],"enables":[104,143],"algorithms":[106],"determine":[108],"each":[118],"because":[121],"two-element":[123],"set":[124,244],"extended":[126],"a":[128,241],"specified":[129],"interval.":[131],"Moreover,":[132],"can":[137,157,221,272],"handle":[138],"uncertain":[139,257],"information,":[140],"which":[141],"effective":[145],"m":[149],"-locus":[150],"combinations":[151],"with":[152,205],"similar":[153,160],"distributions.":[154],"FSMOMDR":[155,197,230],"also":[158],"distinguish":[159],"frequencies":[161],"among":[162],"genotype":[163],"combinations,":[164],"enabling":[166],"more":[170],"significant":[171],"SNP-SNP":[172,234,277],"interactions.":[173],"On":[174],"basis":[176],"accuracy":[180],"rate":[181],"results":[185,212],"obtained":[186,245],"from":[187,246],"analysis":[189],"several":[191],"test":[192],"data":[193,243],"sets,":[194],"determined":[196],"superior":[200],"other":[202],"MDR-based":[203],"methods":[204],"respect":[206],"rate.":[210],"indicate":[213],"classifications":[218],"involving":[219],"provide":[222],"insight":[223],"into":[224],"uncertainty":[225],"risk":[227],"classification.":[228],"could":[231,254],"successfully":[232,255],"detect":[233],"coronary":[237],"artery":[238],"large":[242],"Wellcome":[248],"Trust":[249],"Case":[250],"Control":[251],"Consortium.":[252],"We":[253],"reduce":[256],"information":[258],"MDR":[260],"suggest":[263],"based":[266],"on":[267],"function":[271],"used":[274],"identify":[276],"well":[280],"obtain":[282],"content":[283],"knowledge.":[284]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
