{"id":"https://openalex.org/W2993272395","doi":"https://doi.org/10.1109/access.2019.2955564","title":"Improving Depth Sensitive Fluorescence Spectroscopy With Wavefront Shaping by Spectral and Spatial Filtering","display_name":"Improving Depth Sensitive Fluorescence Spectroscopy With Wavefront Shaping by Spectral and Spatial Filtering","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2993272395","doi":"https://doi.org/10.1109/access.2019.2955564","mag":"2993272395"},"language":"en","primary_location":{"id":"doi:10.1109/access.2019.2955564","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2955564","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08911319.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08911319.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084965142","display_name":"Chao-Mao Hsieh","orcid":"https://orcid.org/0000-0002-8860-1649"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Chao-Mao Hsieh","raw_affiliation_strings":["School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103079979","display_name":"Manish Verma","orcid":"https://orcid.org/0000-0001-6366-9420"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Manish Verma","raw_affiliation_strings":["School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072478964","display_name":"Quan Liu","orcid":"https://orcid.org/0000-0001-7730-5775"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Quan Liu","raw_affiliation_strings":["School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084965142"],"corresponding_institution_ids":["https://openalex.org/I172675005"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.4884,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.56407563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":null,"first_page":"170192","last_page":"170198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11996","display_name":"Random lasers and scattering media","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11996","display_name":"Random lasers and scattering media","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wavefront","display_name":"Wavefront","score":0.7733323574066162},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.6936032772064209},{"id":"https://openalex.org/keywords/spectroscopy","display_name":"Spectroscopy","score":0.5630192160606384},{"id":"https://openalex.org/keywords/fluorescence-spectroscopy","display_name":"Fluorescence spectroscopy","score":0.5391957759857178},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.5052688717842102},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4975879490375519},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4899705946445465},{"id":"https://openalex.org/keywords/adaptive-optics","display_name":"Adaptive optics","score":0.48476049304008484},{"id":"https://openalex.org/keywords/scattering","display_name":"Scattering","score":0.476111501455307},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.4256989657878876},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3446164131164551},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32334214448928833}],"concepts":[{"id":"https://openalex.org/C165699331","wikidata":"https://www.wikidata.org/wiki/Q461533","display_name":"Wavefront","level":2,"score":0.7733323574066162},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6936032772064209},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.5630192160606384},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.5391957759857178},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.5052688717842102},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4975879490375519},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4899705946445465},{"id":"https://openalex.org/C132771110","wikidata":"https://www.wikidata.org/wiki/Q506922","display_name":"Adaptive optics","level":2,"score":0.48476049304008484},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.476111501455307},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4256989657878876},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3446164131164551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32334214448928833},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/access.2019.2955564","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2955564","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08911319.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:86487ba107194f1a890fae0cca1f887b","is_oa":true,"landing_page_url":"https://doaj.org/article/86487ba107194f1a890fae0cca1f887b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 7, Pp 170192-170198 (2019)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/145927","is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/145927","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1109/access.2019.2955564","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2955564","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08911319.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1233310532","display_name":null,"funder_award_id":"NAM/15004","funder_id":"https://openalex.org/F4320320766","funder_display_name":"Nanyang Technological University"},{"id":"https://openalex.org/G2023881915","display_name":null,"funder_award_id":"MOE2015-T2-2-112","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G2064790790","display_name":null,"funder_award_id":"H17/01/a0/008","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"},{"id":"https://openalex.org/G2764426690","display_name":null,"funder_award_id":"H17/01/a0/0F9","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"},{"id":"https://openalex.org/G2884910486","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"},{"id":"https://openalex.org/G3449675161","display_name":null,"funder_award_id":"MOE2017-T2-2-057","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"}],"funders":[{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320320766","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2993272395.pdf","grobid_xml":"https://content.openalex.org/works/W2993272395.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1479838483","https://openalex.org/W1786673417","https://openalex.org/W1965982374","https://openalex.org/W1971965883","https://openalex.org/W1982095576","https://openalex.org/W1982980172","https://openalex.org/W1989568798","https://openalex.org/W2001116122","https://openalex.org/W2004023149","https://openalex.org/W2008913411","https://openalex.org/W2013125633","https://openalex.org/W2020537642","https://openalex.org/W2022437246","https://openalex.org/W2079336472","https://openalex.org/W2081758400","https://openalex.org/W2083582159","https://openalex.org/W2094032733","https://openalex.org/W2094655382","https://openalex.org/W2100470220","https://openalex.org/W2114368628","https://openalex.org/W2122559905","https://openalex.org/W2126033219","https://openalex.org/W2137502999","https://openalex.org/W2137580688","https://openalex.org/W2145458836","https://openalex.org/W2147607085","https://openalex.org/W2148474445","https://openalex.org/W2153936654","https://openalex.org/W2169847880","https://openalex.org/W2171112073","https://openalex.org/W2181827855","https://openalex.org/W2316888153","https://openalex.org/W2566982585","https://openalex.org/W2621991696","https://openalex.org/W2751496889","https://openalex.org/W2759176516","https://openalex.org/W2766577925","https://openalex.org/W2791054599","https://openalex.org/W2963208773","https://openalex.org/W3098241368","https://openalex.org/W3103996473","https://openalex.org/W4233147482","https://openalex.org/W6628904833"],"related_works":["https://openalex.org/W2049040703","https://openalex.org/W1994127078","https://openalex.org/W2048446592","https://openalex.org/W2996224838","https://openalex.org/W3017180796","https://openalex.org/W2069955960","https://openalex.org/W2154607131","https://openalex.org/W2046546828","https://openalex.org/W3006686693","https://openalex.org/W2055108729"],"abstract_inverted_index":{"Depth":[0],"sensitive":[1,34,98,137,235],"optical":[2,6,25,35,236,262],"spectroscopy":[3,139,237,263],"preferentially":[4],"detects":[5],"spectra":[7],"from":[8,106,114,161,206],"different":[9],"depths":[10],"in":[11,19,40,86,96,102,146,203,214,220,238,259,277],"layered":[12,268],"samples,":[13],"which":[14,180,212,278],"plays":[15],"a":[16,48,76,198,250],"crucial":[17],"role":[18,186],"many":[20],"applications":[21],"such":[22,270],"as":[23,271],"the":[24,44,72,80,103,107,112,115,133,158,162,166,185,193,207,239,254,265,279],"diagnosis":[26],"of":[27,82,135,187,200,222,241,256,267,281],"epithelial":[28,272],"precancer":[29],"and":[30,127,174],"cancer.":[31],"In":[32,119],"depth":[33,45,73,97,136,234,260],"measurements,":[36],"multiple":[37],"light":[38,69],"scattering":[39,148],"tissues":[41,87,273],"significantly":[42,131],"degrades":[43],"sensitivity":[46,74],"to":[47,67,70,75,93,111,165,184,216],"subsurface":[49],"target":[50,77,108,163,208],"layer.":[51,78,118],"To":[52],"address":[53],"this":[54,120],"issue,":[55],"feedback":[56,142,167,242],"based":[57,143,243],"wavefront":[58,144,170,244,257],"shaping":[59,145,258],"led":[60],"by":[61,141,155],"guide":[62,84,284],"stars":[63,85],"can":[64,130],"be":[65],"used":[66],"refocus":[68],"increase":[71],"However,":[79],"lack":[81],"intrinsic":[83],"or":[88,189,274,288],"tissue-like":[89,147],"samples":[90],"often":[91],"leads":[92],"poor":[94],"enhancement":[95,202,219,227],"Raman/fluorescence":[99],"measurements":[100],"(~20%":[101],"past":[104],"literature)":[105],"layer":[109,164,209],"due":[110],"contribution":[113,160,205],"overlaying":[116],"non-target":[117],"study,":[121],"we":[122],"demonstrate":[123],"that":[124],"spatial":[125],"filtering":[126,129,152,194],"spectral":[128],"improve":[132],"performance":[134],"fluorescence":[138,178,204],"assisted":[140],"phantoms.":[149],"The":[150],"two":[151],"techniques":[153,195],"work":[154,248],"effectively":[156],"increasing":[157],"relative":[159],"signal":[168],"during":[169],"optimization":[171],"through":[172],"spatially":[173],"spectrally":[175],"rejecting":[176],"off-target":[177],"light,":[179],"is":[181,210,213,286],"essentially":[182],"similar":[183],"time":[188],"coherence":[190],"gating.":[191],"When":[192],"are":[196],"applied,":[197],"maximum":[199],"three-fold":[201],"observed,":[211],"contrast":[215],"nearly":[217],"no":[218,223],"case":[221],"filtering.":[224],"This":[225],"significant":[226],"has":[228],"not":[229,289],"been":[230],"reported":[231],"previously":[232],"for":[233,264],"area":[240],"shaping.":[245],"Therefore,":[246],"our":[247],"represents":[249],"new":[251],"advance":[252],"towards":[253],"application":[255],"resolved":[261],"characterization":[266],"structures":[269],"drug":[275],"tablets,":[276],"creation":[280],"an":[282],"external":[283],"star":[285],"challenging":[287],"allowed.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
