{"id":"https://openalex.org/W2947643675","doi":"https://doi.org/10.1109/access.2019.2919000","title":"Full-SAW Microfluidics-Based Lab-on-a-Chip for Biosensing","display_name":"Full-SAW Microfluidics-Based Lab-on-a-Chip for Biosensing","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2947643675","doi":"https://doi.org/10.1109/access.2019.2919000","mag":"2947643675"},"language":"en","primary_location":{"id":"doi:10.1109/access.2019.2919000","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2919000","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08723025.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08723025.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009925062","display_name":"Matteo Agostini","orcid":"https://orcid.org/0000-0002-5228-1022"},"institutions":[{"id":"https://openalex.org/I4210087815","display_name":"Istituto Nanoscienze","ror":"https://ror.org/0042e5975","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087815","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210108356","display_name":"National Enterprise for NanoScience and NanoTechnology","ror":"https://ror.org/01sgfhb12","country_code":"IT","type":"facility","lineage":["https://openalex.org/I157210198","https://openalex.org/I162290304","https://openalex.org/I30771326","https://openalex.org/I4210087815","https://openalex.org/I4210108356","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Agostini","raw_affiliation_strings":["Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy","institution_ids":["https://openalex.org/I4210108356","https://openalex.org/I4210087815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077622093","display_name":"Gina Greco","orcid":"https://orcid.org/0000-0002-9432-8431"},"institutions":[{"id":"https://openalex.org/I4210087815","display_name":"Istituto Nanoscienze","ror":"https://ror.org/0042e5975","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087815","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210108356","display_name":"National Enterprise for NanoScience and NanoTechnology","ror":"https://ror.org/01sgfhb12","country_code":"IT","type":"facility","lineage":["https://openalex.org/I157210198","https://openalex.org/I162290304","https://openalex.org/I30771326","https://openalex.org/I4210087815","https://openalex.org/I4210108356","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gina Greco","raw_affiliation_strings":["Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy","institution_ids":["https://openalex.org/I4210108356","https://openalex.org/I4210087815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084886246","display_name":"Marco Cecchini","orcid":"https://orcid.org/0000-0002-9688-2356"},"institutions":[{"id":"https://openalex.org/I4210087815","display_name":"Istituto Nanoscienze","ror":"https://ror.org/0042e5975","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087815","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210108356","display_name":"National Enterprise for NanoScience and NanoTechnology","ror":"https://ror.org/01sgfhb12","country_code":"IT","type":"facility","lineage":["https://openalex.org/I157210198","https://openalex.org/I162290304","https://openalex.org/I30771326","https://openalex.org/I4210087815","https://openalex.org/I4210108356","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Cecchini","raw_affiliation_strings":["Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9688-2356","affiliations":[{"raw_affiliation_string":"Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy","institution_ids":["https://openalex.org/I4210108356","https://openalex.org/I4210087815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":2.2931,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87689645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"70901","last_page":"70909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11160","display_name":"Acoustic Wave Resonator Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11160","display_name":"Acoustic Wave Resonator Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.9242647290229797},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6649666428565979},{"id":"https://openalex.org/keywords/surface-acoustic-wave","display_name":"Surface acoustic wave","score":0.6372230648994446},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.6138586401939392},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.575492262840271},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.5569281578063965},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5535441637039185},{"id":"https://openalex.org/keywords/streptavidin","display_name":"Streptavidin","score":0.5380565524101257},{"id":"https://openalex.org/keywords/resonator","display_name":"Resonator","score":0.46222200989723206},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"Surface plasmon resonance","score":0.44574958086013794},{"id":"https://openalex.org/keywords/quartz-crystal-microbalance","display_name":"Quartz crystal microbalance","score":0.436906635761261},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.37170907855033875},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36053895950317383},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23809731006622314},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.1991400122642517},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.19385313987731934},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1311388909816742},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.10215818881988525}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.9242647290229797},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6649666428565979},{"id":"https://openalex.org/C162954803","wikidata":"https://www.wikidata.org/wiki/Q424074","display_name":"Surface acoustic wave","level":2,"score":0.6372230648994446},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6138586401939392},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.575492262840271},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.5569281578063965},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5535441637039185},{"id":"https://openalex.org/C2776190903","wikidata":"https://www.wikidata.org/wiki/Q421817","display_name":"Streptavidin","level":3,"score":0.5380565524101257},{"id":"https://openalex.org/C97126364","wikidata":"https://www.wikidata.org/wiki/Q349669","display_name":"Resonator","level":2,"score":0.46222200989723206},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.44574958086013794},{"id":"https://openalex.org/C9996572","wikidata":"https://www.wikidata.org/wiki/Q629569","display_name":"Quartz crystal microbalance","level":3,"score":0.436906635761261},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.37170907855033875},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36053895950317383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23809731006622314},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1991400122642517},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.19385313987731934},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1311388909816742},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10215818881988525},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/access.2019.2919000","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2919000","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08723025.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:ricerca.sns.it:11384/91796","is_oa":true,"landing_page_url":"http://hdl.handle.net/11384/91796","pdf_url":"https://ricerca.sns.it/bitstream/11384/91796/1/08723025.pdf","source":{"id":"https://openalex.org/S7407050981","display_name":"Scuola Normale Superiore di Pisa","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7adadbb141e04b39b1bac1e048fb1811","is_oa":true,"landing_page_url":"https://doaj.org/article/7adadbb141e04b39b1bac1e048fb1811","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 7, Pp 70901-70909 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2019.2919000","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2019.2919000","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08723025.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326084","display_name":"Regione Toscana","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947643675.pdf","grobid_xml":"https://content.openalex.org/works/W2947643675.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W289241723","https://openalex.org/W1964724638","https://openalex.org/W1964846027","https://openalex.org/W1964875359","https://openalex.org/W1991671987","https://openalex.org/W2001607419","https://openalex.org/W2010550924","https://openalex.org/W2016921326","https://openalex.org/W2037315293","https://openalex.org/W2082607189","https://openalex.org/W2092804567","https://openalex.org/W2106330541","https://openalex.org/W2127159287","https://openalex.org/W2128609649","https://openalex.org/W2142756470","https://openalex.org/W2146288323","https://openalex.org/W2169876926","https://openalex.org/W2261036342","https://openalex.org/W2274674029","https://openalex.org/W2275863778","https://openalex.org/W2335213505","https://openalex.org/W2610375524","https://openalex.org/W2727540899","https://openalex.org/W2766883958","https://openalex.org/W2803446458","https://openalex.org/W2805687099"],"related_works":["https://openalex.org/W4243616808","https://openalex.org/W6746358","https://openalex.org/W2002166601","https://openalex.org/W159511838","https://openalex.org/W4284704689","https://openalex.org/W2645406450","https://openalex.org/W4378978456","https://openalex.org/W2050121346","https://openalex.org/W2161658658","https://openalex.org/W2536608059"],"abstract_inverted_index":{"Many":[0],"approaches":[1],"to":[2,56,90],"diagnostic":[3],"testing":[4],"remain":[5],"decades":[6],"old.":[7],"Well-established":[8],"biosensing":[9],"technologies":[10],"(e.g.,":[11,37],"enzyme-linked":[12],"immunosorbent":[13],"assays":[14,94],"and":[15,24,42,65,178],"radio-immunoassays)":[16],"typically":[17],"cannot":[18],"fulfill":[19],"the":[20,105,125,144,171,179,192],"requirements":[21],"of":[22,26,110,127,155,194],"portability":[23],"ease":[25],"use":[27],"necessary":[28],"for":[29,71,191],"point-of-care":[30],"purposes.":[31],"Several":[32],"alternatives":[33],"have":[34],"been":[35],"proposed":[36],"quartz-crystal-microbalances,":[38],"electrochemical":[39],"sensors,":[40],"cantilevers,":[41],"surface-plasmon-resonance":[43],"sensors)":[44],"but":[45],"often":[46],"lack":[47],"high":[48,138],"performance":[49],"or":[50],"still":[51],"necessitate":[52],"bulk":[53],"ancillary":[54],"instruments":[55],"operate.":[57],"Here":[58],"we":[59,84],"present":[60,141],"a":[61,129,161],"highly":[62,92],"sensitive,":[63],"versatile,":[64],"easily":[66],"integrable":[67],"microfluidic":[68],"lab-on-a-chip":[69],"(LoC)":[70],"biosensing,":[72],"fully":[73],"based":[74],"on":[75],"surface":[76],"acoustic":[77],"waves":[78],"(SAWs).":[79],"By":[80],"using":[81],"ultra-high-frequency":[82],"resonator-biosensors,":[83],"show":[85],"that":[86,148],"it":[87],"is":[88,102],"possible":[89],"perform":[91],"sensitive":[93],"in":[95,108,132,157,196],"complex":[96,158],"media.":[97,159],"This":[98,184],"all-electrical":[99],"readout":[100],"platform":[101,169],"benchmarked":[103],"with":[104,124,143,163],"biotin-streptavidin":[106],"binding":[107,112],"presence":[109],"non-specific":[111],"proteins":[113],"(serum":[114],"albumin)":[115],"at":[116,137],"physiological":[117],"concentration.":[118],"The":[119],"benchmark":[120],"experiments":[121],"were":[122],"performed":[123],"idea":[126],"mimicking":[128],"biological":[130,197],"fluid,":[131],"which":[133],"other":[134],"molecular":[135],"species":[136],"concentration":[139],"are":[140],"together":[142],"analytes.":[145],"We":[146],"demonstrate":[147],"this":[149,167],"LoC":[150,186],"can":[151],"detect":[152],"sub-nanomolar":[153],"concentrations":[154],"analytes":[156],"As":[160],"comparison":[162],"similar":[164],"acoustic-wave-based":[165],"systems,":[166],"full-SAW":[168,185],"outperforms":[170],"standard":[172],"commercial":[173],"gravimetric":[174],"sensors":[175],"(i.e.,":[176],"quartz-crystal-microbalances)":[177],"more":[180],"common":[181],"Love-SAW":[182],"biosensors.":[183],"could":[187],"be":[188],"further":[189],"developed":[190],"detection":[193],"biomarkers":[195],"fluids.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
