{"id":"https://openalex.org/W2896861622","doi":"https://doi.org/10.1109/access.2018.2885518","title":"The Multi-Scale Impact of the Alzheimer\u2019s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks","display_name":"The Multi-Scale Impact of the Alzheimer\u2019s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2896861622","doi":"https://doi.org/10.1109/access.2018.2885518","mag":"2896861622"},"language":"en","primary_location":{"id":"doi:10.1109/access.2018.2885518","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2885518","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2018.2885518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084092008","display_name":"Michael Taynnan Barros","orcid":"https://orcid.org/0000-0002-9765-7660"},"institutions":[{"id":"https://openalex.org/I7478328","display_name":"Waterford Institute of Technology","ror":"https://ror.org/03ypxwh20","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I7478328"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael Taynnan Barros","raw_affiliation_strings":["Telecommunication Software and Systems Group, Waterford Institute of Technology, Waterford, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-9765-7660","affiliations":[{"raw_affiliation_string":"Telecommunication Software and Systems Group, Waterford Institute of Technology, Waterford, Ireland","institution_ids":["https://openalex.org/I7478328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065035079","display_name":"Walisson de Souza e Silva","orcid":"https://orcid.org/0000-0002-6693-2383"},"institutions":[{"id":"https://openalex.org/I3018006580","display_name":"Instituto Federal de Educa\u00e7\u00e3o Ci\u00eancia e Tecnologia da Para\u00edba","ror":"https://ror.org/01xc5jm57","country_code":"BR","type":"education","lineage":["https://openalex.org/I3018006580"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Walisson Silva","raw_affiliation_strings":["Federal Institute of Education, Science and Technology of Para\u00edba, Jo\u00e3o Pessoa, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute of Education, Science and Technology of Para\u00edba, Jo\u00e3o Pessoa, Brazil","institution_ids":["https://openalex.org/I3018006580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052766585","display_name":"Carlos Danilo Miranda Regis","orcid":"https://orcid.org/0000-0002-3555-0024"},"institutions":[{"id":"https://openalex.org/I3018006580","display_name":"Instituto Federal de Educa\u00e7\u00e3o Ci\u00eancia e Tecnologia da Para\u00edba","ror":"https://ror.org/01xc5jm57","country_code":"BR","type":"education","lineage":["https://openalex.org/I3018006580"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Danilo Miranda Regis","raw_affiliation_strings":["Federal Institute of Education, Science and Technology of Para\u00edba, Jo\u00e3o Pessoa, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute of Education, Science and Technology of Para\u00edba, Jo\u00e3o Pessoa, Brazil","institution_ids":["https://openalex.org/I3018006580"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.4494,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.80976467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"6","issue":null,"first_page":"78904","last_page":"78917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte","display_name":"Astrocyte","score":0.7435844540596008},{"id":"https://openalex.org/keywords/molecular-communication","display_name":"Molecular communication","score":0.7145805954933167},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.6309598684310913},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.616298496723175},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4934615194797516},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4875797629356384},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.46953284740448},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.3599521517753601},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.304173082113266},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.2668512463569641},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25270164012908936},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17628559470176697},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1006341278553009},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.09633803367614746},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.08274167776107788}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7435844540596008},{"id":"https://openalex.org/C2779767902","wikidata":"https://www.wikidata.org/wiki/Q17037278","display_name":"Molecular communication","level":4,"score":0.7145805954933167},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.6309598684310913},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.616298496723175},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4934615194797516},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4875797629356384},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46953284740448},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.3599521517753601},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.304173082113266},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2668512463569641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25270164012908936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17628559470176697},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1006341278553009},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09633803367614746},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.08274167776107788},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C47798520","wikidata":"https://www.wikidata.org/wiki/Q190157","display_name":"Transmitter","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/access.2018.2885518","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2885518","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ea1caafc846140108cca0d23700a43b9","is_oa":true,"landing_page_url":"https://doaj.org/article/ea1caafc846140108cca0d23700a43b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 6, Pp 78904-78917 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/access.2018.2885518","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2885518","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5863449022","display_name":null,"funder_award_id":"GOIPD/2016/650","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G7226090481","display_name":"CONNECT: The Centre for Future Networks & Communications","funder_award_id":"13/RC/2077","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1486208308","https://openalex.org/W1663064082","https://openalex.org/W1970820517","https://openalex.org/W1988499586","https://openalex.org/W2005478754","https://openalex.org/W2010172543","https://openalex.org/W2018648013","https://openalex.org/W2029227072","https://openalex.org/W2030127292","https://openalex.org/W2034537762","https://openalex.org/W2036288989","https://openalex.org/W2039232566","https://openalex.org/W2042670485","https://openalex.org/W2054691085","https://openalex.org/W2057286673","https://openalex.org/W2058624548","https://openalex.org/W2058740279","https://openalex.org/W2065705799","https://openalex.org/W2069888362","https://openalex.org/W2075447040","https://openalex.org/W2084972185","https://openalex.org/W2087058693","https://openalex.org/W2088242218","https://openalex.org/W2088873749","https://openalex.org/W2092030050","https://openalex.org/W2096410114","https://openalex.org/W2115742965","https://openalex.org/W2128650885","https://openalex.org/W2129896258","https://openalex.org/W2155418451","https://openalex.org/W2160485538","https://openalex.org/W2169061810","https://openalex.org/W2171502370","https://openalex.org/W2172294131","https://openalex.org/W2214722615","https://openalex.org/W2219140418","https://openalex.org/W2258320835","https://openalex.org/W2329336071","https://openalex.org/W2333207028","https://openalex.org/W2483776236","https://openalex.org/W2537558553","https://openalex.org/W2556381928","https://openalex.org/W2584102230","https://openalex.org/W2591218273","https://openalex.org/W2645661223","https://openalex.org/W2736005079","https://openalex.org/W2762639468","https://openalex.org/W2774446342","https://openalex.org/W2775056312","https://openalex.org/W2791832538","https://openalex.org/W2799538659","https://openalex.org/W2888546046","https://openalex.org/W2950653190","https://openalex.org/W4294620485","https://openalex.org/W4300072715"],"related_works":["https://openalex.org/W2163496989","https://openalex.org/W2054910325","https://openalex.org/W3135645983","https://openalex.org/W3000508184","https://openalex.org/W1493890705","https://openalex.org/W2610758737","https://openalex.org/W2782595656","https://openalex.org/W2283480350","https://openalex.org/W2052126869","https://openalex.org/W2554633690"],"abstract_inverted_index":{"The":[0,169],"Internet":[1],"of":[2,34,38,55,66,80,114,184],"Bio-Nano-Things":[3],"is":[4],"a":[5,43,77,151,190],"new":[6],"paradigm":[7],"that":[8,46,93,172],"can":[9,188],"bring":[10],"novel":[11],"remotely":[12],"controlled":[13],"actuation":[14],"and":[15,82,91,106,127,143,149,166,201,217],"sensing":[16,25],"techniques":[17,26,54],"inside":[18],"the":[19,28,32,48,56,64,67,88,96,138,141,173,178],"human":[20],"body.":[21],"Toward":[22],"precise":[23],"bionano":[24],"in":[27,70],"brain,":[29],"we":[30,62,147],"investigate":[31,63],"challenges":[33],"modeling":[35],"spatial":[36],"distribution":[37],"astrocyte":[39,186],"networks":[40,86,187],"by":[41],"developing":[42],"mathematical":[44],"framework":[45],"lays":[47],"groundwork":[49],"for":[50,95],"future":[51],"early":[52],"detection":[53],"neurodegenerative":[57],"disease.":[58,74],"In":[59],"this":[60],"paper,":[61],"effect":[65,192],"\u03b2-amyloid":[68],"plaques":[69],"astrocytes":[71,85,107,115,196],"with":[72,155,197,209],"Alzheimer's":[73,83,185],"We":[75,109],"developed":[76],"computation":[78],"model":[79,136],"healthy":[81,207],"diseases":[84],"from":[87],"state-of-the-art":[89],"models":[90],"results":[92,170],"account":[94],"intracellular":[97,142],"pathways,":[98],"IP3":[99],"dynamics,":[100],"gap":[101],"junctions,":[102],"voltage-gated":[103],"calcium":[104],"channels,":[105],"volumes.":[108],"also":[110],"implemented":[111],"different":[112],"types":[113],"network":[116,216,220],"topologies,":[117],"including":[118],"shortcut":[119],"networks,":[120,123,126],"regular":[121],"degree":[122],"Erd\u00f6s":[124,214],"R\u00e9nyi":[125,215],"link":[128,218],"radius":[129,219],"networks.":[130],"A":[131],"proposed":[132],"multi-scale":[133,191],"stochastic":[134],"computational":[135],"captures":[137],"relationship":[139],"between":[140,195],"intercellular":[144],"scales.":[145],"Finally,":[146],"designed":[148],"evaluated":[150],"singlehop":[152],"communication":[153,194],"system":[154],"frequency":[156],"modulation":[157],"using":[158],"metrics":[159],"such":[160],"as":[161],"propagation":[162],"extend,":[163],"molecular":[164,199],"delay,":[165],"channel":[167,203],"gain.":[168],"show":[171],"more":[174],"unstable":[175],"but":[176],"at":[177],"same":[179],"time":[180],"lower":[181,202],"level":[182],"oscillations":[183],"create":[189],"on":[193,213],"increased":[198],"delay":[200],"gain":[204],"compared":[205],"to":[206],"astrocytes,":[208],"an":[210],"elevated":[211],"impact":[212],"topologies.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}
