{"id":"https://openalex.org/W2902930318","doi":"https://doi.org/10.1109/access.2018.2884126","title":"Delta Radiomics Improves Pulmonary Nodule Malignancy Prediction in Lung Cancer Screening","display_name":"Delta Radiomics Improves Pulmonary Nodule Malignancy Prediction in Lung Cancer Screening","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2902930318","doi":"https://doi.org/10.1109/access.2018.2884126","mag":"2902930318"},"language":"en","primary_location":{"id":"doi:10.1109/access.2018.2884126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2884126","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1109/access.2018.2884126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016883774","display_name":"Saeed Alahmari","orcid":"https://orcid.org/0000-0001-7344-9448"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saeed S. Alahmari","raw_affiliation_strings":["Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA"],"raw_orcid":"https://orcid.org/0000-0001-7344-9448","affiliations":[{"raw_affiliation_string":"Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048607623","display_name":"Dmitry Cherezov","orcid":"https://orcid.org/0000-0001-5246-1544"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry Cherezov","raw_affiliation_strings":["Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053211631","display_name":"Dmitry B. Goldgof","orcid":"https://orcid.org/0000-0001-5461-863X"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry B. Goldgof","raw_affiliation_strings":["Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000168449","display_name":"Lawrence Hall","orcid":"https://orcid.org/0000-0002-7898-8456"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence O. Hall","raw_affiliation_strings":["Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences and Engineering, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082346230","display_name":"Robert J. Gillies","orcid":"https://orcid.org/0000-0002-8888-7747"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Gillies","raw_affiliation_strings":["Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066835564","display_name":"Matthew B. Schabath","orcid":"https://orcid.org/0000-0003-3241-3216"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B. Schabath","raw_affiliation_strings":["Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016883774"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":5.7343,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.96831755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"6","issue":null,"first_page":"77796","last_page":"77806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.8976631164550781},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.7096942663192749},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6293139457702637},{"id":"https://openalex.org/keywords/malignancy","display_name":"Malignancy","score":0.6077398061752319},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5958814024925232},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"Lung cancer screening","score":0.5000662803649902},{"id":"https://openalex.org/keywords/nodule","display_name":"Nodule (geology)","score":0.46930837631225586},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.44704416394233704},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.41741201281547546},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4062952399253845},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34375423192977905},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34184959530830383},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.20732331275939941},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.12839025259017944},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11803010106086731}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.8976631164550781},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7096942663192749},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6293139457702637},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6077398061752319},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5958814024925232},{"id":"https://openalex.org/C2777405583","wikidata":"https://www.wikidata.org/wiki/Q6704277","display_name":"Lung cancer screening","level":3,"score":0.5000662803649902},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.46930837631225586},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.44704416394233704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41741201281547546},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4062952399253845},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34375423192977905},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34184959530830383},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.20732331275939941},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12839025259017944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11803010106086731},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/access.2018.2884126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2884126","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},{"id":"pmh:oai:digitalcommons.usf.edu:esb_facpub-1113","is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/esb_facpub/113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computer Science and Engineering Faculty Publications","raw_type":"article"},{"id":"pmh:oai:scholarcommons.usf.edu:esb_facpub-1113","is_oa":false,"landing_page_url":"https://scholarcommons.usf.edu/esb_facpub/113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computer Science and Engineering Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4a3a7d93d516421294393dc0901c86b2","is_oa":true,"landing_page_url":"https://doaj.org/article/4a3a7d93d516421294393dc0901c86b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access, Vol 6, Pp 77796-77806 (2018)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6312194","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6312194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Access","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/access.2018.2884126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2884126","pdf_url":null,"source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Access","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4039895282","display_name":null,"funder_award_id":"U01-CA143062","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4948394863","display_name":null,"funder_award_id":"U24 CA180927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W3822628","https://openalex.org/W130099911","https://openalex.org/W1213336605","https://openalex.org/W1514907448","https://openalex.org/W1583700199","https://openalex.org/W1661871015","https://openalex.org/W1924689489","https://openalex.org/W1968114652","https://openalex.org/W2008056655","https://openalex.org/W2017837130","https://openalex.org/W2061077502","https://openalex.org/W2062744135","https://openalex.org/W2086148793","https://openalex.org/W2087676836","https://openalex.org/W2097475056","https://openalex.org/W2109117547","https://openalex.org/W2119821739","https://openalex.org/W2131987814","https://openalex.org/W2132147596","https://openalex.org/W2133990480","https://openalex.org/W2149706766","https://openalex.org/W2154053567","https://openalex.org/W2155063211","https://openalex.org/W2157825442","https://openalex.org/W2166962164","https://openalex.org/W2174661749","https://openalex.org/W2227602841","https://openalex.org/W2289073724","https://openalex.org/W2470491115","https://openalex.org/W2482351703","https://openalex.org/W2523312410","https://openalex.org/W2599895745","https://openalex.org/W2605851261","https://openalex.org/W2617267541","https://openalex.org/W2767128594","https://openalex.org/W2911964244","https://openalex.org/W4236137412","https://openalex.org/W4239510810","https://openalex.org/W4292865245","https://openalex.org/W6630611256","https://openalex.org/W6636914306","https://openalex.org/W6640261747","https://openalex.org/W6738180639"],"related_works":["https://openalex.org/W3000891326","https://openalex.org/W4205100762","https://openalex.org/W2559998622","https://openalex.org/W2605851261","https://openalex.org/W2734724112","https://openalex.org/W2582997534","https://openalex.org/W3009210156","https://openalex.org/W4388577230","https://openalex.org/W2011970480","https://openalex.org/W4403642195"],"abstract_inverted_index":{"Low-dose":[0],"computed":[1],"tomography":[2],"(LDCT)":[3],"plays":[4],"a":[5,53],"critical":[6],"role":[7],"in":[8,82,88,100,181],"the":[9,16,43,111,131,136,164,182],"early":[10,20],"detection":[11,21,36],"of":[12,19,28,35,37,45,113,167,179],"lung":[13,68,101,126,183],"cancer.":[14],"Despite":[15],"life-saving":[17],"benefit":[18],"by":[22],"LDCT,":[23],"there":[24],"are":[25],"many":[26],"limitations":[27],"this":[29,161],"imaging":[30],"modality":[31],"including":[32],"high":[33],"rates":[34],"indeterminate":[38],"pulmonary":[39],"nodules.":[40],"Radiomics":[41],"is":[42],"process":[44],"extracting":[46],"and":[47],"analyzing":[48],"image-based,":[49],"quantitative":[50],"features":[51,83,120,146,151,158,171,175],"from":[52],"region-of-interest":[54],"which":[55],"then":[56],"can":[57,66],"be":[58],"analyzed":[59],"to":[60,109,124,176],"develop":[61],"decision":[62],"support":[63],"tools":[64],"that":[65,77],"improve":[67,177],"cancer":[69,102,184],"screening.":[70,103],"Although":[71],"prior":[72],"published":[73],"research":[74],"has":[75,94],"shown":[76],"delta":[78,98,115,145,169],"radiomics":[79,99,170,174],"(i.e.,":[80],"changes":[81],"over":[84],"time)":[85],"have":[86],"utility":[87,166],"predicting":[89],"treatment":[90],"response,":[91],"limited":[92],"work":[93],"been":[95],"conducted":[96,107],"using":[97,121],"As":[104],"such,":[105],"we":[106],"analyses":[108],"assess":[110],"performance":[112,178],"incorporating":[114],"with":[116,149,172],"conventional":[117,150,157,173],"(non":[118],"delta)":[119],"machine":[122],"learning":[123],"predict":[125],"nodule":[127],"malignancy.":[128],"We":[129],"found":[130],"best":[132],"improved":[133],"area":[134],"under":[135],"receiver":[137],"operating":[138],"characteristic":[139],"curve":[140],"(AUC)":[141],"was":[142],"0.822":[143],"when":[144],"were":[147],"combined":[148],"versus":[152],"an":[153],"AUC":[154],"0.773":[155],"for":[156],"only.":[159],"Overall,":[160],"paper":[162],"demonstrates":[163],"important":[165],"combining":[168],"models":[180],"screening":[185],"setting.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2018-12-11T00:00:00"}