{"id":"https://openalex.org/W1601709137","doi":"https://doi.org/10.1109/acc.2015.7172001","title":"Simultaneous design and control framework for multi-segment multi-addition plug-flow crystallizer for anti-solvent crystallizations","display_name":"Simultaneous design and control framework for multi-segment multi-addition plug-flow crystallizer for anti-solvent crystallizations","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W1601709137","doi":"https://doi.org/10.1109/acc.2015.7172001","mag":"1601709137"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2015.7172001","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2015.7172001","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.lboro.ac.uk/2134/19117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035333089","display_name":"Qinglin Su","orcid":"https://orcid.org/0000-0002-6840-1631"},"institutions":[{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qinglin Su","raw_affiliation_strings":["Chemical Engineering Department, Loughborough University, UK","Chemical Engineering Department, Loughborough University, LE11 3TU UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering Department, Loughborough University, UK","institution_ids":["https://openalex.org/I143804889"]},{"raw_affiliation_string":"Chemical Engineering Department, Loughborough University, LE11 3TU UK","institution_ids":["https://openalex.org/I143804889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046274300","display_name":"Chris D. Rielly","orcid":"https://orcid.org/0000-0002-1110-189X"},"institutions":[{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris D. Rielly","raw_affiliation_strings":["Chemical Engineering Department, Loughborough University, UK","Chemical Engineering Department, Loughborough University, LE11 3TU UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering Department, Loughborough University, UK","institution_ids":["https://openalex.org/I143804889"]},{"raw_affiliation_string":"Chemical Engineering Department, Loughborough University, LE11 3TU UK","institution_ids":["https://openalex.org/I143804889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057438733","display_name":"Zolt\u00e1n K. Nagy","orcid":"https://orcid.org/0000-0003-4787-6678"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoltan K. Nagy","raw_affiliation_strings":["School of Chemical Engineering, Purdue University, West Lafayette, IN, USA","School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 \u2013 2100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 \u2013 2100, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4276","last_page":"4281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystallization","display_name":"Crystallization","score":0.7424596548080444},{"id":"https://openalex.org/keywords/plug-flow","display_name":"Plug flow","score":0.7165197134017944},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.5857867002487183},{"id":"https://openalex.org/keywords/residence-time-distribution","display_name":"Residence time distribution","score":0.5050850510597229},{"id":"https://openalex.org/keywords/nucleation","display_name":"Nucleation","score":0.47700121998786926},{"id":"https://openalex.org/keywords/supersaturation","display_name":"Supersaturation","score":0.47651445865631104},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.4135361313819885},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.40921109914779663},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.35638388991355896},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.326986700296402},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.291705846786499},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22719210386276245},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.1208203136920929}],"concepts":[{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.7424596548080444},{"id":"https://openalex.org/C191545125","wikidata":"https://www.wikidata.org/wiki/Q383758","display_name":"Plug flow","level":2,"score":0.7165197134017944},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.5857867002487183},{"id":"https://openalex.org/C144058455","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Residence time distribution","level":3,"score":0.5050850510597229},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.47700121998786926},{"id":"https://openalex.org/C200447597","wikidata":"https://www.wikidata.org/wiki/Q334104","display_name":"Supersaturation","level":2,"score":0.47651445865631104},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.4135361313819885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40921109914779663},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.35638388991355896},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.326986700296402},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.291705846786499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22719210386276245},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.1208203136920929},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/acc.2015.7172001","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2015.7172001","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 American Control Conference (ACC)","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.lboro.ac.uk:2134/19117","is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/19117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Contribution"},{"id":"pmh:oai:figshare.com:article/9245387","is_oa":true,"landing_page_url":"https://figshare.com/articles/conference_contribution/Simultaneous_design_and_control_framework_for_multi-segment_multi-addition_plug-flow_crystallizer_for_anti-solvent_crystallizations/9245387","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"<dc:type>Conference contribution"}],"best_oa_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/19117","is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/19117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Contribution"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1524777652","display_name":null,"funder_award_id":"EP/K014250/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1963885647","https://openalex.org/W1969372975","https://openalex.org/W1970433183","https://openalex.org/W1974353829","https://openalex.org/W1987291580","https://openalex.org/W2000885428","https://openalex.org/W2001032983","https://openalex.org/W2001902736","https://openalex.org/W2013996326","https://openalex.org/W2036082779","https://openalex.org/W2044838247","https://openalex.org/W2045133945","https://openalex.org/W2073591017","https://openalex.org/W2081093458","https://openalex.org/W2118078149","https://openalex.org/W2316815274"],"related_works":["https://openalex.org/W2431749009","https://openalex.org/W2864580978","https://openalex.org/W226119683","https://openalex.org/W3126832077","https://openalex.org/W2742609606","https://openalex.org/W2278771383","https://openalex.org/W1963885647","https://openalex.org/W3096204237","https://openalex.org/W3191437358","https://openalex.org/W2986254079","https://openalex.org/W2894148127","https://openalex.org/W2091666907","https://openalex.org/W9866146","https://openalex.org/W1989428604","https://openalex.org/W2898336385","https://openalex.org/W3201480898","https://openalex.org/W2892433992","https://openalex.org/W2937782758","https://openalex.org/W171158120","https://openalex.org/W2057556135"],"abstract_inverted_index":{"Tubular":[0],"reactors,":[1,10],"which":[2,56,67,156,206],"are":[3,57,135,166],"often":[4],"assumed":[5],"to":[6,69,112,144,167,181],"behave":[7],"as":[8,60,83,120,178],"plug-flow":[9,131,141],"have":[11,41,97],"many":[12],"applications":[13],"in":[14,155,204],"chemical":[15],"reaction":[16],"engineering,":[17],"because":[18],"of":[19,27,35,80,151,163,174,185,214],"their":[20],"narrow":[21],"residence":[22,95],"time":[23,96],"distribution":[24,162],"and":[25,38,53,73,88,93,103,149,161],"ease":[26],"scaling-up.":[28],"In":[29,125],"the":[30,33,44,78,114,121,146,157,183,197,201,212],"pharmaceutical":[31,65],"industries,":[32],"requirements":[34],"fast":[36],"development":[37],"scalable":[39],"design":[40,148,199],"also":[42,222],"made":[43],"tubular":[45],"crystallizer":[46,132,142,187],"a":[47,106,138],"promising":[48,116],"platform":[49],"for":[50,64],"continuous":[51],"manufacturing":[52,66],"crystallization":[54,153,172],"processes":[55],"widely":[58],"recognized":[59],"an":[61,179],"emerging":[62],"technology":[63],"aims":[68],"replace":[70],"conventional":[71],"capital-":[72],"labor-intensive":[74],"batch":[75,217],"operations.":[76],"However,":[77],"interaction":[79],"effects,":[81],"such":[82,119],"supersaturation,":[84],"seed":[85],"loading,":[86],"nucleation":[87],"crystal":[89,122],"growth,":[90],"tube":[91],"configuration":[92],"mean":[94],"not":[98],"yet":[99],"been":[100],"fully":[101],"understood":[102],"optimized,":[104],"from":[105],"process":[107],"systems":[108],"engineering":[109],"(PSE)":[110],"perspective,":[111],"achieve":[113],"most":[115],"product":[117],"qualities,":[118],"size":[123],"distribution.":[124],"this":[126],"study,":[127],"standardized":[128],"modules":[129],"representing":[130],"(PFC)":[133],"segments":[134],"assembled":[136],"into":[137],"multi-segment":[139],"multi-addition":[140],"(MSMA-PFC)":[143],"facilitate":[145],"versatile":[147],"control":[150],"anti-solvent":[152,164,171,209],"processes,":[154],"total":[158],"number,":[159],"locations,":[160],"addition":[165],"be":[168],"optimized.":[169],"An":[170],"system":[173],"paracetamol-acetone-water":[175],"was":[176,194],"used":[177],"example":[180],"compare":[182],"performances":[184],"different":[186],"configurations":[188],"operated":[189],"under":[190],"optimal":[191],"design.":[192],"It":[193],"noticed":[195],"that":[196],"proposed":[198],"outperforms":[200],"previous":[202],"designs":[203],"literature":[205],"considered":[207],"equally-spaced":[208],"additions.":[210],"Furthermore,":[211],"possibility":[213],"replacing":[215],"existing":[216],"crystallizers":[218],"by":[219],"MSMA-PFC":[220],"is":[221],"discussed.":[223]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
