{"id":"https://openalex.org/W2126820441","doi":"https://doi.org/10.1109/acc.2014.6858854","title":"The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant","display_name":"The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2126820441","doi":"https://doi.org/10.1109/acc.2014.6858854","mag":"2126820441"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2014.6858854","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2014.6858854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008637769","display_name":"Richard Lakerveld","orcid":"https://orcid.org/0000-0001-7444-2678"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Lakerveld","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072025114","display_name":"Brahim Benyahia","orcid":"https://orcid.org/0000-0002-5397-1498"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brahim Benyahia","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067906479","display_name":"Patrick L. Heider","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick L. Heider","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454595","display_name":"Hai\u2010Tao Zhang","orcid":"https://orcid.org/0009-0001-3305-5767"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haitao Zhang","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027570301","display_name":"Aaron Wolfe","orcid":"https://orcid.org/0000-0002-4926-5064"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Wolfe","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109227861","display_name":"Chris Testa","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Testa","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003536833","display_name":"Sean Ogden","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Ogden","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069099348","display_name":"Devin R. Hersey","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin R. Hersey","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043839284","display_name":"Salvatore Mascia","orcid":"https://orcid.org/0000-0002-9583-8839"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore Mascia","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111597343","display_name":"James M. B. Evans","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M.B. Evans","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083684552","display_name":"Richard D. Braatz","orcid":"https://orcid.org/0000-0003-4304-3484"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Braatz","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037278011","display_name":"Paul I. Barton","orcid":"https://orcid.org/0000-0003-2895-9443"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul I. Barton","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US","Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5008637769"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.18344765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":null,"first_page":"3512","last_page":"3517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmaceutical-manufacturing","display_name":"Pharmaceutical manufacturing","score":0.7590396404266357},{"id":"https://openalex.org/keywords/manufacturing-engineering","display_name":"Manufacturing engineering","score":0.6181964874267578},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.56036376953125},{"id":"https://openalex.org/keywords/pilot-plant","display_name":"Pilot plant","score":0.5498164892196655},{"id":"https://openalex.org/keywords/process-control","display_name":"Process control","score":0.5414308309555054},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5284538269042969},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.5055899620056152},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4680131673812866},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.46030193567276},{"id":"https://openalex.org/keywords/product","display_name":"Product (mathematics)","score":0.43744656443595886},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.33066052198410034},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3239005208015442},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10018664598464966},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09432542324066162},{"id":"https://openalex.org/keywords/waste-management","display_name":"Waste management","score":0.09134447574615479}],"concepts":[{"id":"https://openalex.org/C2778938233","wikidata":"https://www.wikidata.org/wiki/Q7180757","display_name":"Pharmaceutical manufacturing","level":2,"score":0.7590396404266357},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.6181964874267578},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.56036376953125},{"id":"https://openalex.org/C2780956279","wikidata":"https://www.wikidata.org/wiki/Q577117","display_name":"Pilot plant","level":2,"score":0.5498164892196655},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.5414308309555054},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5284538269042969},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5055899620056152},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4680131673812866},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.46030193567276},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.43744656443595886},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.33066052198410034},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3239005208015442},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10018664598464966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09432542324066162},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.09134447574615479},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/acc.2014.6858854","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2014.6858854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 American Control Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-62721","is_oa":false,"landing_page_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346492604015","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W105695126","https://openalex.org/W1532102145","https://openalex.org/W1770883461","https://openalex.org/W1983367166","https://openalex.org/W1988718129","https://openalex.org/W1998154903","https://openalex.org/W2017896325","https://openalex.org/W2045667156","https://openalex.org/W2054691671","https://openalex.org/W2061872918","https://openalex.org/W2112211764","https://openalex.org/W2113433055","https://openalex.org/W2140837669","https://openalex.org/W2141223569","https://openalex.org/W2146993554","https://openalex.org/W2154400019","https://openalex.org/W2166896249","https://openalex.org/W2315703870","https://openalex.org/W2504091950","https://openalex.org/W3110471395"],"related_works":["https://openalex.org/W2274537270","https://openalex.org/W67532948","https://openalex.org/W2213851874","https://openalex.org/W4206296042","https://openalex.org/W4229930767","https://openalex.org/W114260869","https://openalex.org/W2289437898","https://openalex.org/W1480154954","https://openalex.org/W3131671888","https://openalex.org/W1599968825"],"abstract_inverted_index":{"Continuous":[0],"manufacturing":[1,11],"has":[2],"the":[3,10,24,39,70,75,78],"potential":[4],"to":[5,9,16,61,83],"provide":[6],"substantial":[7],"improvements":[8],"of":[12,26,34,42,69,77,91],"pharmaceutical":[13,51,57],"products":[14],"compared":[15],"traditional":[17],"batch-wise":[18],"manufacturing.":[19],"A":[20],"key":[21],"challenge":[22],"is":[23],"development":[25],"effective":[27],"control":[28,46,72],"strategies":[29],"for":[30,48,87],"this":[31],"new":[32],"type":[33],"process.":[35],"This":[36],"contribution":[37],"presents":[38],"experimental":[40],"application":[41],"an":[43],"automated":[44,71],"plant-wide":[45],"strategy":[47],"a":[49,56,64,88],"continuous":[50,65],"pilot":[52],"plant":[53],"that":[54],"produces":[55],"product":[58],"from":[59],"start":[60],"finish":[62],"in":[63],"fashion.":[66],"The":[67],"performance":[68],"loops":[73],"demonstrate":[74],"maintenance":[76],"critical":[79],"material":[80],"attributes":[81],"close":[82],"their":[84],"desired":[85],"setpoints":[86],"sustained":[89],"period":[90],"operation.":[92]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
