{"id":"https://openalex.org/W1989962331","doi":"https://doi.org/10.1109/acc.2013.6580413","title":"Gene target identification for biofilm-associated pathogens: an application to pseudomonas aeruginosa","display_name":"Gene target identification for biofilm-associated pathogens: an application to pseudomonas aeruginosa","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W1989962331","doi":"https://doi.org/10.1109/acc.2013.6580413","mag":"1989962331"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2013.6580413","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580413","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089790370","display_name":"Zhaobin Xu","orcid":"https://orcid.org/0000-0002-1136-5684"},"institutions":[{"id":"https://openalex.org/I7863295","display_name":"Villanova University","ror":"https://ror.org/02g7kd627","country_code":"US","type":"education","lineage":["https://openalex.org/I7863295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhaobin Xu","raw_affiliation_strings":["Chemical Engineering, Villanova University, Villanova, PA, USA","Chem. Eng., Villanova Univ., Villanova, PA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical Engineering, Villanova University, Villanova, PA, USA","institution_ids":["https://openalex.org/I7863295"]},{"raw_affiliation_string":"Chem. Eng., Villanova Univ., Villanova, PA, USA","institution_ids":["https://openalex.org/I7863295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001961475","display_name":"Xin Fang","orcid":"https://orcid.org/0000-0002-4118-7815"},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Fang","raw_affiliation_strings":["Advancement of Military Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA","Henry M. Jackson Found. for the Advancement of Mil. Med., Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"Advancement of Military Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"Henry M. Jackson Found. for the Advancement of Mil. Med., Bethesda, MD, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082173877","display_name":"Thomas K. Wood","orcid":"https://orcid.org/0000-0002-6258-529X"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K. Wood","raw_affiliation_strings":["Departments of Chemical Engineering and Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA","Depts. of Chem. Eng. & Biochem. & Mol. Biol., Pennsylvania State Univ., University Park, PA, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Depts. of Chem. Eng. & Biochem. & Mol. Biol., Pennsylvania State Univ., University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090194358","display_name":"Zuyi Huang","orcid":"https://orcid.org/0000-0002-1393-2961"},"institutions":[{"id":"https://openalex.org/I7863295","display_name":"Villanova University","ror":"https://ror.org/02g7kd627","country_code":"US","type":"education","lineage":["https://openalex.org/I7863295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuyi Huang","raw_affiliation_strings":["Chemical Engineering, Villanova University, Villanova, PA, USA","Chem. Eng., Villanova Univ., Villanova, PA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical Engineering, Villanova University, Villanova, PA, USA","institution_ids":["https://openalex.org/I7863295"]},{"raw_affiliation_string":"Chem. Eng., Villanova Univ., Villanova, PA, USA","institution_ids":["https://openalex.org/I7863295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089790370"],"corresponding_institution_ids":["https://openalex.org/I7863295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05403445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":null,"first_page":"3765","last_page":"3770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11791","display_name":"Microbial Community Ecology and Physiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biofilm","display_name":"Biofilm","score":0.9697739481925964},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9107218384742737},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6981407403945923},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.6847245693206787},{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.6502258777618408},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6401715874671936},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.493843138217926},{"id":"https://openalex.org/keywords/human-pathogen","display_name":"Human pathogen","score":0.46862083673477173},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.4679652154445648},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.433064341545105},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22595611214637756}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9697739481925964},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.9107218384742737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6981407403945923},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6847245693206787},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6502258777618408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6401715874671936},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.493843138217926},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.46862083673477173},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4679652154445648},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.433064341545105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22595611214637756}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2013.6580413","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580413","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1969846013","https://openalex.org/W1981085402","https://openalex.org/W2010579377","https://openalex.org/W2013964962","https://openalex.org/W2019516978","https://openalex.org/W2036748232","https://openalex.org/W2048625951","https://openalex.org/W2059260241","https://openalex.org/W2081492047","https://openalex.org/W2105173502","https://openalex.org/W2115933619","https://openalex.org/W2116854231","https://openalex.org/W2119642783","https://openalex.org/W2130780855","https://openalex.org/W2147472054","https://openalex.org/W2152394523","https://openalex.org/W2162237022","https://openalex.org/W2166481425","https://openalex.org/W4238101851","https://openalex.org/W4255375128"],"related_works":["https://openalex.org/W4319459883","https://openalex.org/W2377024769","https://openalex.org/W2365912673","https://openalex.org/W2984106036","https://openalex.org/W3030861211","https://openalex.org/W2301938379","https://openalex.org/W2952275400","https://openalex.org/W3212778000","https://openalex.org/W3101528127","https://openalex.org/W2037903640"],"abstract_inverted_index":{"Prevention":[0],"of":[1,4,19,55,136,145,150,175,195],"the":[2,8,17,40,51,68,97,101,134,143,148,191],"initiation":[3],"biofilm":[5,52,108],"formation":[6,53,109,144],"is":[7,24,75,129],"most":[9,137,151],"important":[10],"step":[11],"for":[12,96,186],"combating":[13],"biofilm-associated":[14,48],"pathogens,":[15],"as":[16,67,182],"ability":[18],"pathogens":[20],"to":[21,27,36,46,64,79,89,119,123,131,169],"resist":[22],"antibiotics":[23],"enhanced":[25],"10":[26],"1000":[28],"times":[29],"once":[30],"they":[31,111],"form":[32,71],"biofilms.":[33],"Genes":[34],"essential":[35,61,95,138,157],"bacterial":[37,98],"growth":[38],"in":[39,59,100,190],"planktonic":[41,102],"state":[42,103],"are":[43,94,112],"potential":[44,183],"targets":[45,92,168,185],"treat":[47,124,170],"pathogens.":[49],"However,":[50],"capability":[54],"strains":[56],"with":[57],"mutations":[58],"these":[60,176],"genes":[62,122,140,153,177],"needs":[63],"be":[65],"evaluated,":[66],"pathogen":[69],"might":[70,141,154],"biofilms":[72,146],"before":[73],"it":[74],"eliminated.":[76],"In":[77],"order":[78],"address":[80],"this":[81,83],"issue,":[82],"work":[84],"proposes":[85],"a":[86],"systems-biology":[87],"approach":[88,116],"identify":[90,120],"gene":[91,167],"that":[93,133],"metabolism":[99],"but":[104],"do":[105],"not":[106],"induce":[107,142],"when":[110],"inactivated.":[113],"The":[114],"proposed":[115],"was":[117],"applied":[118],"target":[121],"Pseudomonas":[125],"aeruginosa":[126],"infections.":[127],"It":[128],"interesting":[130],"find":[132],"inhibition":[135,149],"planktonic-growth":[139,158],"while":[147],"non-essential":[152],"not.":[155],"Four":[156],"genes,":[159],"i.e.,":[160],"lysC,":[161],"cysH,":[162],"adk,":[163],"and":[164],"galU,":[165],"constitute":[166],"P.":[171,196],"aeruginosa.":[172,197],"All":[173],"four":[174],"have":[178],"been":[179],"experimentally":[180],"suggested":[181],"drug":[184],"their":[187],"crucial":[188],"role":[189],"survival":[192],"or":[193],"virulence":[194]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}