{"id":"https://openalex.org/W2032939082","doi":"https://doi.org/10.1109/acc.2013.6580140","title":"LQR tracking of a delay differential equation model for the study of nanoparticle dosing strategies for cancer therapy","display_name":"LQR tracking of a delay differential equation model for the study of nanoparticle dosing strategies for cancer therapy","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W2032939082","doi":"https://doi.org/10.1109/acc.2013.6580140","mag":"2032939082"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2013.6580140","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580140","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072836630","display_name":"Pratik Adhikari","orcid":null},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratik Adhikari","raw_affiliation_strings":["Student of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","Biomed. Eng., Louisiana Tech. Univ., Ruston, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]},{"raw_affiliation_string":"Biomed. Eng., Louisiana Tech. Univ., Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080065683","display_name":"Scarlett S. Bracey","orcid":null},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scarlett S. Bracey","raw_affiliation_strings":["Student of Computational Analysis and Modeling, Louisiana Tech University, Ruston, LA, USA","Comput. Anal. & Modeling, Louisiana Tech Univ., Ruston, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student of Computational Analysis and Modeling, Louisiana Tech University, Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]},{"raw_affiliation_string":"Comput. Anal. & Modeling, Louisiana Tech Univ., Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036744281","display_name":"Katie A. Evans","orcid":null},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie A. Evans","raw_affiliation_strings":["Faculty of Mathematics and Statistics, Louisiana Tech University, Ruston, LA, USA","Fac. of Math. & Stat., Louisiana Tech Univ., Ruston, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Statistics, Louisiana Tech University, Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]},{"raw_affiliation_string":"Fac. of Math. & Stat., Louisiana Tech Univ., Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075595146","display_name":"Isidro B. Maga\u00f1a","orcid":"https://orcid.org/0000-0002-5204-3243"},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isidro B. Magana","raw_affiliation_strings":["Student of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","Biomed. Eng., Louisiana Tech. Univ., Ruston, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]},{"raw_affiliation_string":"Biomed. Eng., Louisiana Tech. Univ., Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008289992","display_name":"D. Patrick O\u2019Neal","orcid":"https://orcid.org/0000-0001-6573-1945"},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Patrick O'Neal","raw_affiliation_strings":["Faculty of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","Fac. of Biomed. Eng., Louisiana Tech Univ., Ruston, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]},{"raw_affiliation_string":"Fac. of Biomed. Eng., Louisiana Tech Univ., Ruston, LA, USA","institution_ids":["https://openalex.org/I919208787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I919208787"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"2068","last_page":"2073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.6620105504989624},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.5933175086975098},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.5705147981643677},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"Cancer therapy","score":0.5410593152046204},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.49252161383628845},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4866965115070343},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.45914432406425476},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4209054708480835},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2533932626247406},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19679605960845947},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17149192094802856},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16950294375419617},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16564133763313293},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.12928006052970886},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.12376290559768677}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6620105504989624},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.5933175086975098},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.5705147981643677},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5410593152046204},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.49252161383628845},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4866965115070343},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45914432406425476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4209054708480835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2533932626247406},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19679605960845947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17149192094802856},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16950294375419617},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16564133763313293},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.12928006052970886},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12376290559768677},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2013.6580140","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580140","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W44078951","https://openalex.org/W1968895422","https://openalex.org/W1970916399","https://openalex.org/W1978186749","https://openalex.org/W1987483448","https://openalex.org/W2014466852","https://openalex.org/W2023808520","https://openalex.org/W2032798297","https://openalex.org/W2038963357","https://openalex.org/W2049804905","https://openalex.org/W2060542320","https://openalex.org/W2081444498","https://openalex.org/W2107169663","https://openalex.org/W2118683725","https://openalex.org/W4390951742","https://openalex.org/W6601788095"],"related_works":["https://openalex.org/W3166797618","https://openalex.org/W2915644342","https://openalex.org/W2159406923","https://openalex.org/W4288738052","https://openalex.org/W2911677179","https://openalex.org/W4391224393","https://openalex.org/W2151922639","https://openalex.org/W3034286462","https://openalex.org/W1992426253","https://openalex.org/W2124818340"],"abstract_inverted_index":{"Currently,":[0],"the":[1,18,21,48,51,55,59,107,125,165,169,180,186,198,201,204],"most":[2],"commonly":[3,118],"used":[4],"treatments":[5],"for":[6,23,68,146,185,215],"cancerous":[7],"tumors":[8],"(chemotherapy,":[9],"radiation,":[10],"etc.)":[11],"have":[12],"almost":[13],"no":[14,44,73,81],"method":[15,42],"of":[16,20,46,50,109,121,140,148,188,200,203],"monitoring":[17],"administration":[19],"treatment":[22,36],"adverse":[24],"effects":[25,49,202],"in":[26,124,144,156,168,178,197,206],"real":[27,31],"time.":[28],"Without":[29],"any":[30],"time":[32,173],"feedback":[33,160],"or":[34],"control,":[35],"becomes":[37],"a":[38,117,157,207],"\u201cguess":[39],"and":[40,78,94,128,182,218],"check\u201d":[41],"with":[43,100],"way":[45],"predicting":[47],"drugs":[52,205],"based":[53],"on":[54],"actual":[56],"bioavailability":[57],"to":[58,75,84,102,112,163,212],"patient's":[60,208],"body.":[61],"One":[62],"particular":[63],"drug":[64,122,216],"may":[65],"be":[66],"effective":[67],"one":[69],"patient,":[70],"yet":[71],"provide":[72],"benefit":[74],"another.":[76],"Doctors":[77],"scientists":[79],"do":[80],"routinely":[82],"attempt":[83],"quantifiably":[85],"explain":[86],"this":[87,90,134],"discrepancy.":[88],"In":[89],"work,":[91],"mathematical":[92],"modeling":[93],"analysis":[95],"techniques":[96],"are":[97],"joined":[98],"together":[99],"experimentation":[101],"gain":[103],"further":[104],"insight":[105],"into":[106],"challenges":[108],"nanoparticle":[110,166],"delivery":[111,147],"tumor":[113],"sites.":[114],"There":[115],"exists":[116],"accepted":[119],"model":[120,135,152],"clearance":[123],"pharmacokinetics":[126],"community,":[127],"it":[129],"is":[130,153,175],"demonstrated":[131],"here":[132],"that":[133],"provides":[136],"an":[137],"accurate":[138],"reflection":[139],"reality,":[141],"as":[142],"observed":[143],"experiment":[145],"gold-coated":[149],"nanorods.":[150],"This":[151,193],"then":[154],"utilized":[155],"state":[158,181],"space":[159],"control":[161,183],"framework":[162],"regulate":[164],"concentration":[167],"bloodstream.":[170],"An":[171],"equal":[172],"delay":[174],"also":[176],"introduced":[177],"both":[179],"input":[184],"purpose":[187],"studying":[189],"alternate":[190],"dosing":[191],"strategies.":[192],"study":[194],"will":[195],"aid":[196],"prediction":[199],"body,":[209],"thus":[210],"leading":[211],"better":[213],"models":[214],"regimen":[217],"administration.":[219]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
