{"id":"https://openalex.org/W2045552729","doi":"https://doi.org/10.1109/acc.2013.6580112","title":"Modeling and control of protein crystal shape distribution","display_name":"Modeling and control of protein crystal shape distribution","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W2045552729","doi":"https://doi.org/10.1109/acc.2013.6580112","mag":"2045552729"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2013.6580112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049141672","display_name":"Michael Nayhouse","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Nayhouse","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028617759","display_name":"Joseph Sang\u2010Il Kwon","orcid":"https://orcid.org/0000-0002-7903-5681"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Sang-Il Kwon","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012189317","display_name":"Gerassimos Orkoulas","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerassimos Orkoulas","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Chem. & Biomol. Eng., Univ. of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002367171","display_name":"Panagiotis D. Christofides","orcid":"https://orcid.org/0000-0002-8772-4348"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panagiotis D. Christofides","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering and Department of Electrical Engineering, University of California, Los Angeles, CA, USA","Dept. of Chem. & Biomol. Eng. & the Dept. of Electr. Eng., Univ. of California, Los Angeles, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering and Department of Electrical Engineering, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Chem. & Biomol. Eng. & the Dept. of Electr. Eng., Univ. of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049141672"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08815233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1896","last_page":"1901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetic-monte-carlo","display_name":"Kinetic Monte Carlo","score":0.7030388116836548},{"id":"https://openalex.org/keywords/crystallization","display_name":"Crystallization","score":0.6840035319328308},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"Protein crystallization","score":0.6830301880836487},{"id":"https://openalex.org/keywords/nucleation","display_name":"Nucleation","score":0.5910083651542664},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5455169677734375},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.5204882025718689},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5034846663475037},{"id":"https://openalex.org/keywords/desorption","display_name":"Desorption","score":0.5027575492858887},{"id":"https://openalex.org/keywords/tetragonal-crystal-system","display_name":"Tetragonal crystal system","score":0.48467662930488586},{"id":"https://openalex.org/keywords/crystal","display_name":"Crystal (programming language)","score":0.4809233844280243},{"id":"https://openalex.org/keywords/lysozyme","display_name":"Lysozyme","score":0.45785555243492126},{"id":"https://openalex.org/keywords/crystal-growth","display_name":"Crystal growth","score":0.42864325642585754},{"id":"https://openalex.org/keywords/adsorption","display_name":"Adsorption","score":0.36045804619789124},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.3437155485153198},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3109239935874939},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.3038853108882904},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"Crystal structure","score":0.2367577850818634},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21619698405265808},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20223233103752136},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17188507318496704},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.16042867302894592},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08852499723434448}],"concepts":[{"id":"https://openalex.org/C45786274","wikidata":"https://www.wikidata.org/wiki/Q3333611","display_name":"Kinetic Monte Carlo","level":3,"score":0.7030388116836548},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.6840035319328308},{"id":"https://openalex.org/C153064111","wikidata":"https://www.wikidata.org/wiki/Q1281033","display_name":"Protein crystallization","level":3,"score":0.6830301880836487},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.5910083651542664},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5455169677734375},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5204882025718689},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5034846663475037},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.5027575492858887},{"id":"https://openalex.org/C170751736","wikidata":"https://www.wikidata.org/wiki/Q503601","display_name":"Tetragonal crystal system","level":3,"score":0.48467662930488586},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.4809233844280243},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.45785555243492126},{"id":"https://openalex.org/C26456737","wikidata":"https://www.wikidata.org/wiki/Q185154","display_name":"Crystal growth","level":2,"score":0.42864325642585754},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.36045804619789124},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.3437155485153198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3109239935874939},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3038853108882904},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.2367577850818634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21619698405265808},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20223233103752136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17188507318496704},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.16042867302894592},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08852499723434448},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2013.6580112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2013.6580112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5299999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1599175522","https://openalex.org/W1972585513","https://openalex.org/W1973341137","https://openalex.org/W1979621040","https://openalex.org/W1987368754","https://openalex.org/W1989395389","https://openalex.org/W1991426413","https://openalex.org/W1993721898","https://openalex.org/W2009572041","https://openalex.org/W2011106336","https://openalex.org/W2016107710","https://openalex.org/W2016455886","https://openalex.org/W2036223873","https://openalex.org/W2042321087","https://openalex.org/W2054048343","https://openalex.org/W2063691025","https://openalex.org/W2063993669","https://openalex.org/W2064277013","https://openalex.org/W2067516819","https://openalex.org/W2070739476","https://openalex.org/W2071960572","https://openalex.org/W2074681199","https://openalex.org/W2084782536","https://openalex.org/W2084924279","https://openalex.org/W2085061065","https://openalex.org/W2092127890","https://openalex.org/W2095162303","https://openalex.org/W2095921114","https://openalex.org/W2124153771","https://openalex.org/W2129522178","https://openalex.org/W2130543390","https://openalex.org/W2137971290","https://openalex.org/W2140993382","https://openalex.org/W2155149633","https://openalex.org/W2155418451","https://openalex.org/W2167154952","https://openalex.org/W2221066201","https://openalex.org/W2327909219","https://openalex.org/W4241366409"],"related_works":["https://openalex.org/W2081453366","https://openalex.org/W2022802672","https://openalex.org/W2361332783","https://openalex.org/W341904646","https://openalex.org/W2095477540","https://openalex.org/W1976383419","https://openalex.org/W2113290656","https://openalex.org/W2073184671","https://openalex.org/W1974745230","https://openalex.org/W2143441462"],"abstract_inverted_index":{"The":[0,37,116,220],"production":[1],"of":[2,24,49,66,92,105,111,118,128,135,214,241,252],"highly":[3],"ordered,":[4],"high":[5],"quality":[6],"protein":[7,27,55,206],"crystals":[8,68,207],"through":[9],"batch":[10],"crystallization":[11,28],"processes":[12],"is":[13,29,60],"vital":[14],"in":[15,21,33,211,216,249,255],"devising":[16],"proteins":[17],"for":[18,46,102,122,243],"therapeutic":[19],"purposes":[20],"a":[22,30,47,58,172],"number":[23],"diseases.":[25],"Additionally,":[26],"central":[31],"activity":[32],"the":[34,42,78,82,99,119,126,133,136,142,154,160,164,178,184,189,205,212,217,229,244,250,256],"pharmaceutical":[35],"industry.":[36],"present":[38],"work":[39],"focuses":[40],"on":[41,81,141],"modeling":[43],"and":[44,84,95,113,138,145,156,181],"control":[45],"population":[48,247],"tetragonal":[50],"hen":[51],"egg-white":[52],"(HEW)":[53],"lysozyme":[54,67],"crystals.":[56],"First,":[57],"model":[59,77,195],"presented":[61],"which":[62,176,233],"will":[63,167,198],"consider":[64],"nucleation":[65],"followed":[69],"by":[70,152],"kinetic":[71],"Monte":[72],"Carlo":[73],"(kMC)":[74],"simulations":[75,90,130,166],"to":[76,109,132,170,183,203,208,237],"crystal":[79,192,231,246],"growth":[80,120,185],"(110)":[83],"(101)":[85],"faces,":[86],"respectively.":[87],"These":[88],"kMC":[89,129,165],"comprise":[91],"adsorption,":[93],"desorption,":[94],"migration":[96,139],"events":[97],"where":[98],"rate":[100,121,186],"equations":[101],"each":[103,123],"type":[104,240],"event":[106],"are":[107],"similar":[108],"those":[110],"Durbin":[112],"Feher":[114],"[10].":[115],"computation":[117],"face":[124],"requires":[125],"use":[127,199],"due":[131],"dependence":[134],"desorption":[137,157],"rates":[140],"surface":[143],"micro-configuration,":[144],"thus":[146],"it":[147,225],"cannot":[148],"be":[149,168],"computed":[150],"simply":[151],"subtracting":[153],"adsorption":[155],"rates.":[158],"Next,":[159],"data":[161],"obtained":[162],"from":[163,235],"used":[169],"generate":[171],"nonlinear":[173,201],"algebraic":[174],"equation":[175,202],"relates":[177],"solute":[179,257],"concentration":[180],"temperature":[182],"ratio":[187],"between":[188],"two":[190],"independent":[191],"faces.":[193],"A":[194],"predictive":[196],"controller":[197],"this":[200],"regulate":[204],"desired":[209,230],"shapes":[210,232],"presence":[213,251],"disturbance":[215],"operating":[218],"conditions.":[219],"proposed":[221],"method":[222],"demonstrates":[223],"that":[224],"can":[226],"successfully":[227],"achieve":[228],"range":[234],"equidimensional":[236],"more":[238],"elongated":[239],"structures":[242],"entire":[245],"while":[248],"arbitrary":[253],"variations":[254],"concentration.":[258]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
