{"id":"https://openalex.org/W2085570189","doi":"https://doi.org/10.1109/acc.2012.6314940","title":"Determining transcription factor profiles from fluorescent reporter systems involving regularization of inverse problems","display_name":"Determining transcription factor profiles from fluorescent reporter systems involving regularization of inverse problems","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2085570189","doi":"https://doi.org/10.1109/acc.2012.6314940","mag":"2085570189"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2012.6314940","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2012.6314940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063899754","display_name":"Lalit Bansal","orcid":"https://orcid.org/0000-0003-0085-0227"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. Bansal","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111905144","display_name":"Yunfei Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunfei Chu","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030631754","display_name":"Carl D. Laird","orcid":"https://orcid.org/0000-0001-8430-1561"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Laird","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073305158","display_name":"Juergen Hahn","orcid":"https://orcid.org/0000-0002-1078-4203"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Hahn","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering Texas A&M University College Station TX 77843\u20103122 USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063899754"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.5702,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.810208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"263","issue":null,"first_page":"2725","last_page":"2730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9652000069618225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tikhonov-regularization","display_name":"Tikhonov regularization","score":0.9099152088165283},{"id":"https://openalex.org/keywords/inverse-problem","display_name":"Inverse problem","score":0.6460998058319092},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.6401711106300354},{"id":"https://openalex.org/keywords/singular-value-decomposition","display_name":"Singular value decomposition","score":0.6064872741699219},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"Green fluorescent protein","score":0.5815778970718384},{"id":"https://openalex.org/keywords/inverse","display_name":"Inverse","score":0.5345484614372253},{"id":"https://openalex.org/keywords/discretization","display_name":"Discretization","score":0.5039188265800476},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4590988755226135},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4544558525085449},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.4457733929157257},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.44371694326400757},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4253879487514496},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3634352684020996},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.336152046918869},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.25870585441589355},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24223363399505615},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.21767529845237732},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2050829827785492},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16627803444862366},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12205579876899719},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.08626177906990051},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07422083616256714}],"concepts":[{"id":"https://openalex.org/C152442038","wikidata":"https://www.wikidata.org/wiki/Q2778212","display_name":"Tikhonov regularization","level":3,"score":0.9099152088165283},{"id":"https://openalex.org/C135252773","wikidata":"https://www.wikidata.org/wiki/Q1567213","display_name":"Inverse problem","level":2,"score":0.6460998058319092},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.6401711106300354},{"id":"https://openalex.org/C22789450","wikidata":"https://www.wikidata.org/wiki/Q420904","display_name":"Singular value decomposition","level":2,"score":0.6064872741699219},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5815778970718384},{"id":"https://openalex.org/C207467116","wikidata":"https://www.wikidata.org/wiki/Q4385666","display_name":"Inverse","level":2,"score":0.5345484614372253},{"id":"https://openalex.org/C73000952","wikidata":"https://www.wikidata.org/wiki/Q17007827","display_name":"Discretization","level":2,"score":0.5039188265800476},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4590988755226135},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4544558525085449},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4457733929157257},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.44371694326400757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4253879487514496},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3634352684020996},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.336152046918869},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.25870585441589355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24223363399505615},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.21767529845237732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2050829827785492},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16627803444862366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12205579876899719},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.08626177906990051},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07422083616256714},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2012.6314940","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2012.6314940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 American Control Conference (ACC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2015071882","https://openalex.org/W2021246213","https://openalex.org/W2031604650","https://openalex.org/W2032579724","https://openalex.org/W2070672503","https://openalex.org/W2073835183","https://openalex.org/W2091634218","https://openalex.org/W2093487214","https://openalex.org/W2101296410","https://openalex.org/W2114424556","https://openalex.org/W2126802411","https://openalex.org/W2137325336","https://openalex.org/W2153481137","https://openalex.org/W2167898143","https://openalex.org/W2512514633","https://openalex.org/W3046265042","https://openalex.org/W3217247658"],"related_works":["https://openalex.org/W2373436489","https://openalex.org/W2337734184","https://openalex.org/W2388364587","https://openalex.org/W2322955667","https://openalex.org/W2373176546","https://openalex.org/W2127000180","https://openalex.org/W2050033254","https://openalex.org/W2561531189","https://openalex.org/W2152224705","https://openalex.org/W2374214022"],"abstract_inverted_index":{"The":[0],"availability":[1],"and":[2,27,64,70,105,120,129],"quality":[3],"of":[4,13,36,43,49,66,72,95,109,132],"experimental":[5],"data":[6],"pose":[7],"challenges":[8],"for":[9],"identifying":[10],"the":[11,34,57,96,99,107,130,133],"role":[12],"individual":[14],"proteins":[15],"in":[16,126,138],"signal":[17],"transduction":[18],"pathways.":[19],"To":[20],"address":[21],"this":[22,24,84,127],"issue,":[23],"paper":[25],"formulates":[26],"solves":[28],"an":[29],"inverse":[30,101],"problem":[31,102],"to":[32,91],"determine":[33],"dynamics":[35],"transcription":[37,63,73],"factors,":[38],"i.e.,":[39],"one":[40],"important":[41],"class":[42],"proteins,":[44],"from":[45],"fluorescence":[46],"intensity":[47],"measurements":[48],"green":[50],"fluorescent":[51],"protein":[52],"(GFP)":[53],"reporter":[54],"systems.":[55],"In":[56],"presented":[58],"approach,":[59],"a":[60,92],"model":[61],"describing":[62],"translation":[65],"GFP":[67],"is":[68,103],"discretized":[69],"concentrations":[71],"factor":[74],"are":[75,124,136],"estimated":[76],"at":[77],"discrete":[78],"time":[79],"points.":[80],"Unlike":[81],"previous":[82],"works,":[83],"approach":[85],"has":[86],"no":[87],"restrictions":[88],"with":[89],"regard":[90],"particular":[93],"shape":[94],"profiles.":[97],"However,":[98],"resulting":[100],"ill-conditioned":[104],"requires":[106],"use":[108],"regularization":[110,113,122],"techniques.":[111],"Two":[112],"methods":[114],"-":[115,123],"truncated":[116],"singular":[117],"value":[118],"decomposition":[119],"Tikhonov":[121],"investigated":[125],"work":[128],"characteristics":[131],"results":[134],"obtained":[135],"discussed":[137],"detail.":[139]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
