{"id":"https://openalex.org/W2107309344","doi":"https://doi.org/10.1109/acc.2011.5991554","title":"Modeling sporulation decisions in Bacillus subtilis as optimal evolutionary decision-making","display_name":"Modeling sporulation decisions in Bacillus subtilis as optimal evolutionary decision-making","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2107309344","doi":"https://doi.org/10.1109/acc.2011.5991554","mag":"2107309344"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2011.5991554","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2011.5991554","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2011 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063849145","display_name":"Michael Morimoto","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Morimoto","raw_affiliation_strings":["Department of Mechanical Engineering, University of California Berkeley, USA","Department of Mechanical Engineering, U.C. Berkeley, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of California Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Mechanical Engineering, U.C. Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066623854","display_name":"Adam P. Arkin","orcid":"https://orcid.org/0000-0002-4999-2931"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Arkin","raw_affiliation_strings":["Department of Bioengineering, University of California Berkeley, USA","Department of Bioengineering, U.C. Berkeley, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Bioengineering, U.C. Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023927229","display_name":"Kameshwar Poolla","orcid":"https://orcid.org/0000-0001-6098-3537"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kameshwar Poolla","raw_affiliation_strings":["Department of Mechanical Engineering, University of California Berkeley, USA","Department of Mechanical Engineering, U.C. Berkeley, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of California Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Mechanical Engineering, U.C. Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063849145"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13191226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"174","issue":null,"first_page":"3508","last_page":"3513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8262302279472351},{"id":"https://openalex.org/keywords/endospore","display_name":"Endospore","score":0.5519874095916748},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5256724953651428},{"id":"https://openalex.org/keywords/spore","display_name":"Spore","score":0.5103179812431335},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.488455206155777},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.4873717427253723},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4596952497959137},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.4354918897151947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4006524980068207},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3868580162525177},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3572549819946289},{"id":"https://openalex.org/keywords/operations-research","display_name":"Operations research","score":0.3224526643753052},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3222607970237732},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20160910487174988},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.17986398935317993},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.1780456304550171},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.17497235536575317},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13368502259254456},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.12614965438842773},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12065386772155762},{"id":"https://openalex.org/keywords/economics","display_name":"Economics","score":0.11988255381584167},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11711612343788147}],"concepts":[{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.8262302279472351},{"id":"https://openalex.org/C65764964","wikidata":"https://www.wikidata.org/wiki/Q828761","display_name":"Endospore","level":3,"score":0.5519874095916748},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5256724953651428},{"id":"https://openalex.org/C174618031","wikidata":"https://www.wikidata.org/wiki/Q177332","display_name":"Spore","level":2,"score":0.5103179812431335},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.488455206155777},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.4873717427253723},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4596952497959137},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.4354918897151947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4006524980068207},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3868580162525177},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3572549819946289},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.3224526643753052},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3222607970237732},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20160910487174988},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17986398935317993},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.1780456304550171},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.17497235536575317},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13368502259254456},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.12614965438842773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12065386772155762},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.11988255381584167},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11711612343788147},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2011.5991554","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2011.5991554","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2011 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W177502678","https://openalex.org/W177730080","https://openalex.org/W1496850831","https://openalex.org/W1788532922","https://openalex.org/W1870056855","https://openalex.org/W1970394313","https://openalex.org/W1974344653","https://openalex.org/W1975635548","https://openalex.org/W1976811090","https://openalex.org/W1977165087","https://openalex.org/W2004893601","https://openalex.org/W2017880973","https://openalex.org/W2020657021","https://openalex.org/W2022316765","https://openalex.org/W2024373537","https://openalex.org/W2029696940","https://openalex.org/W2032362831","https://openalex.org/W2033679946","https://openalex.org/W2035699290","https://openalex.org/W2059349322","https://openalex.org/W2065212787","https://openalex.org/W2067262661","https://openalex.org/W2068162395","https://openalex.org/W2073227940","https://openalex.org/W2075048236","https://openalex.org/W2085059271","https://openalex.org/W2092740268","https://openalex.org/W2097659572","https://openalex.org/W2114181347","https://openalex.org/W2127240867","https://openalex.org/W2138354977","https://openalex.org/W2139769881","https://openalex.org/W2140775467","https://openalex.org/W2148323109","https://openalex.org/W2157303908","https://openalex.org/W2168860039","https://openalex.org/W2169436065","https://openalex.org/W2169889515","https://openalex.org/W2251026370","https://openalex.org/W2316531379","https://openalex.org/W4210652510","https://openalex.org/W4242009368"],"related_works":["https://openalex.org/W2110453293","https://openalex.org/W975256545","https://openalex.org/W2120409150","https://openalex.org/W2132842689","https://openalex.org/W1967007250","https://openalex.org/W2752027696","https://openalex.org/W1992009956","https://openalex.org/W2232170869","https://openalex.org/W2083054132","https://openalex.org/W2014372295"],"abstract_inverted_index":{"The":[0],"decision":[1,28,39,106],"by":[2],"the":[3,18,27,35,38,55,105,111],"bacterium":[4],"Bacillus":[5],"subtilis":[6],"to":[7,49,73,86,107,119],"produce":[8],"spores":[9],"has":[10],"been":[11,67],"an":[12,71,114],"area":[13],"of":[14,113],"intense":[15],"study":[16],"in":[17,97],"molecular":[19],"cell":[20],"biology":[21],"field.":[22],"Though":[23],"mechanisms":[24,64],"describing":[25],"how":[26],"is":[29,40,47,60],"made":[30,41],"are":[31,42],"becoming":[32],"better":[33],"understood,":[34],"reasons":[36],"why":[37],"still":[43],"nebulous.":[44],"Spore":[45],"formation":[46],"known":[48],"be":[50,110],"a":[51,83,94],"survival":[52,90],"mechanism,":[53],"but":[54],"circumstances":[56],"under":[57],"which":[58],"it":[59],"preferred":[61],"over":[62],"other":[63],"have":[65],"not":[66],"carefully":[68],"examined.":[69],"In":[70],"attempt":[72],"address":[74],"this":[75],"issue":[76],"quantitatively,":[77],"we":[78],"introduce":[79],"simple":[80,95],"models":[81],"and":[82,93],"control":[84,117],"framework":[85],"compare":[87],"two":[88],"bacterial":[89],"strategies:":[91],"sporulation":[92],"reduction":[96],"metabolic":[98],"activity.":[99],"Our":[100],"findings":[101],"provide":[102],"evidence":[103],"that":[104],"sporulate":[108],"may":[109],"outcome":[112],"underlying":[115],"optimal":[116],"problem":[118],"contend":[120],"with":[121],"expected":[122],"future":[123],"environmental":[124],"challenges.":[125]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}