{"id":"https://openalex.org/W2101567771","doi":"https://doi.org/10.1109/acc.2009.5160288","title":"Targeting a fixed percentage of granulocyte differentiation using experiments designed via nonlinear model predictive control","display_name":"Targeting a fixed percentage of granulocyte differentiation using experiments designed via nonlinear model predictive control","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2101567771","doi":"https://doi.org/10.1109/acc.2009.5160288","mag":"2101567771"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2009.5160288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2009.5160288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 American Control Conference","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076247548","display_name":"Sarah L. Noble","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah L. Noble","raw_affiliation_strings":["Electrical and Computer Engineering Department, Purdue University, West Lafayette, IN, USA","Electrical and Computer Engineering Department Purdue University, West Lafayette, IN 47906 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department Purdue University, West Lafayette, IN 47906 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048545593","display_name":"Ann E. Rundell","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann E. Rundell","raw_affiliation_strings":["Biomedical Engineering Department, Purdue University, West Lafayette, IN, USA","Biomedical Engineering Department, Purdue University, West Lafayette, IN 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Biomedical Engineering Department, Purdue University, West Lafayette, IN 47906, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":17.4884,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.98133333,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"70","issue":null,"first_page":"313","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.5623318552970886},{"id":"https://openalex.org/keywords/hl60","display_name":"HL60","score":0.5479745864868164},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.5281990170478821},{"id":"https://openalex.org/keywords/granulocyte","display_name":"Granulocyte","score":0.5035380721092224},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48438602685928345},{"id":"https://openalex.org/keywords/observable","display_name":"Observable","score":0.4355505108833313},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4333476722240448},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4181406497955322},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4100116193294525},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.3331550359725952},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.27430903911590576},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2055579125881195},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17045104503631592},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16978880763053894},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11238199472427368},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10653850436210632}],"concepts":[{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5623318552970886},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.5479745864868164},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.5281990170478821},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.5035380721092224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48438602685928345},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.4355505108833313},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4333476722240448},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4181406497955322},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4100116193294525},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3331550359725952},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27430903911590576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2055579125881195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17045104503631592},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16978880763053894},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11238199472427368},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10653850436210632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2009.5160288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2009.5160288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W13406669","https://openalex.org/W1517396147","https://openalex.org/W1773256867","https://openalex.org/W2014520088","https://openalex.org/W2057620418","https://openalex.org/W2114790553","https://openalex.org/W2146364324","https://openalex.org/W2172079634","https://openalex.org/W6631149122","https://openalex.org/W6685235571"],"related_works":["https://openalex.org/W2077941552","https://openalex.org/W2027402770","https://openalex.org/W2079178379","https://openalex.org/W2093565218","https://openalex.org/W2144480090","https://openalex.org/W2402994936","https://openalex.org/W2146542950","https://openalex.org/W75221901","https://openalex.org/W4234755228","https://openalex.org/W1517396147"],"abstract_inverted_index":{"Previous":[0],"efforts":[1],"to":[2,25,114],"control":[3,42,62],"cellular":[4],"differentiation":[5,71,83,104],"have":[6],"been":[7,23],"largely":[8],"experimental.":[9],"Although":[10],"some":[11],"mathematical":[12],"models":[13],"for":[14,44,110],"this":[15,39],"process":[16],"exist,":[17],"rarely":[18],"has":[19],"a":[20,41,46,66,90,111],"quantitative":[21,112],"approach":[22,113],"employed":[24],"design":[26],"experiments":[27],"that":[28],"predictably":[29],"direct":[30],"the":[31,74,80,94,98,102,108],"cell":[32,70,77],"fate.":[33],"As":[34],"an":[35],"initial":[36],"step":[37],"towards":[38],"aim,":[40],"strategy":[43],"sustaining":[45],"desired":[47],"constant":[48],"level":[49,105],"of":[50,68,97],"differentiated":[51],"human":[52],"promyelocytic":[53],"leukemia":[54],"(HL60)":[55],"cells":[56],"is":[57,63],"proposed.":[58],"Nonlinear":[59],"model":[60,67],"predictive":[61],"applied":[64],"using":[65],"HL60":[69],"which":[72],"reflects":[73],"dominant":[75],"observable":[76],"states":[78],"along":[79],"known":[81],"granulocyte/monocyte":[82],"pathway.":[84],"After":[85],"implementing":[86],"changes":[87],"identified":[88],"by":[89],"preliminary":[91],"experimental":[92,95],"trial,":[93],"realization":[96],"controller":[99],"successfully":[100],"achieved":[101],"target":[103],"and":[106],"demonstrated":[107],"need":[109],"experiment":[115],"design.":[116]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}