{"id":"https://openalex.org/W2130197224","doi":"https://doi.org/10.1109/acc.2008.4586611","title":"Optimal mechano-electric stabilization of cardiac alternans","display_name":"Optimal mechano-electric stabilization of cardiac alternans","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2130197224","doi":"https://doi.org/10.1109/acc.2008.4586611","mag":"2130197224"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2008.4586611","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2008.4586611","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031561953","display_name":"Stevan Dubljevi\u0107","orcid":"https://orcid.org/0000-0002-1889-1599"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stevan Dubljevic","raw_affiliation_strings":["Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA, USA","Cardiovascular Res. Lab., Univ. of California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Cardiovascular Res. Lab., Univ. of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002367171","display_name":"Panagiotis D. Christofides","orcid":"https://orcid.org/0000-0002-8772-4348"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panagiotis Christofides","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","Department of Chemical and Biomolecular Engineering, University of California, Los Angeles 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23647888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":null,"first_page":"926","last_page":"933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.8056038022041321},{"id":"https://openalex.org/keywords/linear-quadratic-regulator","display_name":"Linear-quadratic regulator","score":0.5090007781982422},{"id":"https://openalex.org/keywords/amplitude","display_name":"Amplitude","score":0.4760279953479767},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.43601667881011963},{"id":"https://openalex.org/keywords/beat","display_name":"Beat (acoustics)","score":0.419467031955719},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.3974305987358093},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.38353532552719116},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36392301321029663},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3602314591407776},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3370034396648407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3304857611656189},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.12408718466758728},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.11859935522079468},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.11440899968147278}],"concepts":[{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.8056038022041321},{"id":"https://openalex.org/C98779006","wikidata":"https://www.wikidata.org/wiki/Q2520550","display_name":"Linear-quadratic regulator","level":3,"score":0.5090007781982422},{"id":"https://openalex.org/C180205008","wikidata":"https://www.wikidata.org/wiki/Q159190","display_name":"Amplitude","level":2,"score":0.4760279953479767},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.43601667881011963},{"id":"https://openalex.org/C189809214","wikidata":"https://www.wikidata.org/wiki/Q829522","display_name":"Beat (acoustics)","level":2,"score":0.419467031955719},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.3974305987358093},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.38353532552719116},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36392301321029663},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3602314591407776},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3370034396648407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3304857611656189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12408718466758728},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.11859935522079468},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.11440899968147278},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2008.4586611","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2008.4586611","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W40130861","https://openalex.org/W1538686203","https://openalex.org/W1594759473","https://openalex.org/W1595065160","https://openalex.org/W1965689674","https://openalex.org/W1965716970","https://openalex.org/W1966922258","https://openalex.org/W1977343811","https://openalex.org/W1984336411","https://openalex.org/W1986393509","https://openalex.org/W1988792839","https://openalex.org/W1990595104","https://openalex.org/W2002357820","https://openalex.org/W2002606794","https://openalex.org/W2003519797","https://openalex.org/W2019006705","https://openalex.org/W2023903233","https://openalex.org/W2027518125","https://openalex.org/W2028248314","https://openalex.org/W2045200629","https://openalex.org/W2045850425","https://openalex.org/W2048029738","https://openalex.org/W2066278848","https://openalex.org/W2078746189","https://openalex.org/W2081264254","https://openalex.org/W2081952592","https://openalex.org/W2086126894","https://openalex.org/W2153542388","https://openalex.org/W2154140920","https://openalex.org/W2159148686","https://openalex.org/W2162758272","https://openalex.org/W2977097895","https://openalex.org/W4292366025","https://openalex.org/W4293179290","https://openalex.org/W4386445991"],"related_works":["https://openalex.org/W2770593030","https://openalex.org/W3154990682","https://openalex.org/W2560201613","https://openalex.org/W2171975302","https://openalex.org/W2022352247","https://openalex.org/W4312219546","https://openalex.org/W2377538627","https://openalex.org/W2107220315","https://openalex.org/W2203843426","https://openalex.org/W2049369111"],"abstract_inverted_index":{"Alternation":[0,106],"of":[1,19,42,45,59,107,116,127,197],"normal":[2],"action":[3,99,108],"potential":[4,100,109],"morphology":[5,76],"in":[6,16,66,160,167,180],"the":[7,17,20,30,39,43,57,74,84,93,98,113,128,161,193,198,202],"myocardium":[8],"is":[9,24,35,110,132,150],"a":[10,13,80,153,168,172,181],"condition":[11],"with":[12,171],"beat-to-beat":[14],"oscillation":[15],"length":[18],"electric":[21],"wave":[22],"which":[23],"linked":[25],"through":[26,138,208],"electromechanical":[27],"coupling":[28],"to":[29,37],"cardiac":[31,52],"muscle":[32],"contraction,":[33],"and":[34,50,61,96,140,146,166,175,192,195],"believed":[36],"be":[38],"first":[40],"manifestation":[41],"onset":[44],"life":[46],"threatening":[47],"ventricular":[48],"arrhythmias":[49],"sudden":[51],"death.":[53],"In":[54],"this":[55],"work,":[56],"effects":[58],"electrical":[60],"mechanical":[62,88],"stimuli":[63,71,89],"are":[64,77,90,206],"utilized":[65],"alternans":[67,117,129],"annihilation":[68],"problem.":[69],"Electrical":[70],"that":[72],"alter":[73],"action-potential":[75],"represented":[78],"by":[79,101,112,134,152],"pacer":[81],"located":[82],"at":[83],"domain's":[85],"boundary,":[86],"while":[87],"distributed":[91,142,148],"within":[92],"spatial":[94],"domain":[95],"affect":[97],"altering":[102],"intracellular":[103],"calcium":[104],"kinetics.":[105],"described":[111],"small":[114],"amplitude":[115,130],"parabolic":[118],"partial":[119],"differential":[120],"equation":[121],"(PDE).":[122],"Spatially":[123],"uniform":[124],"unstable":[125],"steady-state":[126],"PDE":[131],"stabilized":[133],"optimal":[135],"control":[136,164,189],"methods":[137],"boundary":[139,145],"spatially":[141,147],"actuation.":[143],"Mixed":[144],"actuation":[149],"manipulated":[151],"finite":[154,182],"dimensional":[155],"linear":[156,204],"quadratic":[157],"regulator":[158],"(LQR)":[159],"full-state":[162],"feedback":[163],"structure":[165],"compensator":[169],"design":[170],"Luenberger-type":[173],"observer,":[174],"it":[176],"achieves":[177],"exponential":[178],"stabilization":[179],"size":[183],"tissue":[184],"cable":[185],"length.":[186],"The":[187],"proposed":[188,203],"problem":[190],"formulation":[191],"performance":[194],"robustness":[196],"closed-loop":[199],"system":[200],"under":[201],"controller":[205],"evaluated":[207],"simulations.":[209]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}