{"id":"https://openalex.org/W2158075343","doi":"https://doi.org/10.1109/acc.2007.4282821","title":"On the Computation of Minimal Cut Sets in Genome Scale Metabolic Networks","display_name":"On the Computation of Minimal Cut Sets in Genome Scale Metabolic Networks","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2158075343","doi":"https://doi.org/10.1109/acc.2007.4282821","mag":"2158075343"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2007.4282821","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282821","pdf_url":null,"source":{"id":"https://openalex.org/S4210168941","display_name":"Proceedings of the ... American Control Conference/Proceedings of the American Control Conference","issn_l":"0743-1619","issn":["0743-1619","2378-5861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013992190","display_name":"Marcin Imieli\u0144ski","orcid":"https://orcid.org/0000-0002-2211-4741"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcin Imielinski","raw_affiliation_strings":["University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086742095","display_name":"C\u0103lin Belta","orcid":"https://orcid.org/0000-0002-7141-2657"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calin Belta","raw_affiliation_strings":["Center for Information and Systems Engineering, Boston University, Brookline, MA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Information and Systems Engineering, Boston University, Brookline, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013992190"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.28503563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"4","issue":null,"first_page":"1329","last_page":"1334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.7730666399002075},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6990291476249695},{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.6213865280151367},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.6148895621299744},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.47550588846206665},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.441464900970459},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.42843562364578247},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4195072054862976},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.3304232954978943},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.16040882468223572},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13631081581115723},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08170497417449951}],"concepts":[{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.7730666399002075},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6990291476249695},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.6213865280151367},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.6148895621299744},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.47550588846206665},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.441464900970459},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.42843562364578247},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4195072054862976},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.3304232954978943},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.16040882468223572},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13631081581115723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08170497417449951},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/acc.2007.4282821","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282821","pdf_url":null,"source":{"id":"https://openalex.org/S4210168941","display_name":"Proceedings of the ... American Control Conference/Proceedings of the American Control Conference","issn_l":"0743-1619","issn":["0743-1619","2378-5861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.331.2394","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.331.2394","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iasi.bu.edu/~cbelta/conference/acc07_marcin_v4.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1526857120","https://openalex.org/W1621975707","https://openalex.org/W1758395617","https://openalex.org/W1963547452","https://openalex.org/W1980717706","https://openalex.org/W1994134392","https://openalex.org/W1994656497","https://openalex.org/W1996529795","https://openalex.org/W2029058413","https://openalex.org/W2060925158","https://openalex.org/W2068065441","https://openalex.org/W2070020713","https://openalex.org/W2084374578","https://openalex.org/W2089476104","https://openalex.org/W2094097101","https://openalex.org/W2094525983","https://openalex.org/W2096245011","https://openalex.org/W2102164505","https://openalex.org/W2107333582","https://openalex.org/W2128572161","https://openalex.org/W2131178894","https://openalex.org/W2133112961","https://openalex.org/W2134981469","https://openalex.org/W2143861551","https://openalex.org/W2148190806","https://openalex.org/W2155331065","https://openalex.org/W2157239641","https://openalex.org/W2162684083","https://openalex.org/W2163823651","https://openalex.org/W2171793445","https://openalex.org/W6636731557"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2373300491","https://openalex.org/W2378744544","https://openalex.org/W2594301978","https://openalex.org/W2379704676","https://openalex.org/W1998810860","https://openalex.org/W4206442282","https://openalex.org/W2384505857","https://openalex.org/W2355171581","https://openalex.org/W2145253956"],"abstract_inverted_index":{"A":[0],"cut":[1,52,127,149],"set":[2,13],"for":[3,102,110,129,140],"an":[4],"objective":[5],"reaction":[6,22,131],"in":[7,93],"a":[8,12,29,36,67,76,85,111,130,164,178],"metabolic":[9,37,68,182],"network":[10,38,69,112],"is":[11],"of":[14,32,35,60,66,75,78,87,97,104,113,119,174,184],"reactions":[15],"whose":[16],"knockout":[17],"disables":[18],"flux":[19,122],"through":[20],"that":[21,144],"at":[23],"steady":[24],"state.":[25],"Cut":[26],"sets":[27,53,128,139,150],"represent":[28],"particular":[30],"type":[31],"failure":[33],"mode":[34],"and":[39,106],"may":[40],"correspond":[41],"to":[42,154,161,177],"novel":[43],"drug":[44],"targets.":[45],"In":[46],"this":[47,175],"paper,":[48],"we":[49,124],"demonstrate":[50,171],"how":[51,126],"can":[54,132,158],"be":[55,133,155,159],"obtained":[56],"from":[57],"the":[58,71,79,94,98,120,141,147,172],"computation":[59,103],"sub-elementary":[61],"modes":[62,73],"(sub-EM).":[63],"The":[64],"sub-EM's":[65,142],"are":[70,107,151],"elementary":[72],"(EM)":[74],"submatrix":[77],"stoichiometry":[80],"matrix":[81],"formed":[82],"by":[83,135],"taking":[84],"subset":[86],"its":[88],"rows.":[89],"Sub-EM's":[90],"emerge":[91],"naturally":[92],"intermediate":[95],"steps":[96],"standard":[99],"tableau":[100],"algorithm":[101],"EM,":[105],"thus":[108],"obtainable":[109],"any":[114],"size.":[115],"By":[116],"employing":[117],"properties":[118],"feasible":[121],"cone,":[123],"show":[125],"constructed":[134],"enumerating":[136],"minimal":[137],"hitting":[138],"containing":[143],"reaction.":[145],"Though":[146],"resulting":[148],"not":[152],"guaranteed":[153],"minimal,":[156],"they":[157],"reduced":[160],"minimality":[162],"via":[163],"second":[165],"linear":[166],"programming":[167],"pruning":[168],"step.":[169],"We":[170],"applicability":[173],"approach":[176],"recent":[179],"genome":[180],"scale":[181],"model":[183],"E.coli.":[185]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}