{"id":"https://openalex.org/W2134543131","doi":"https://doi.org/10.1109/acc.2007.4282604","title":"Stochastic Analysis of Gene Regulatory Networks Using Moment Closure","display_name":"Stochastic Analysis of Gene Regulatory Networks Using Moment Closure","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2134543131","doi":"https://doi.org/10.1109/acc.2007.4282604","mag":"2134543131"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2007.4282604","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282604","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097723089","display_name":"Abhyutdai Sinigh","orcid":null},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abhyutdai Sinigh","raw_affiliation_strings":["Cente for Control Engineering and Computation University of California, Sanita Barbara, CA 93101. abhi@engineering.ucsb.eud"],"affiliations":[{"raw_affiliation_string":"Cente for Control Engineering and Computation University of California, Sanita Barbara, CA 93101. abhi@engineering.ucsb.eud","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065218317","display_name":"Jo\u00e3o P. Hespanha","orcid":"https://orcid.org/0000-0003-2809-4718"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao Pedo Hespanha","raw_affiliation_strings":["Center for Control Engineering and Computation, University of California, Santa Barbara, CA, USA","University of California,Santa Barbara,"],"affiliations":[{"raw_affiliation_string":"Center for Control Engineering and Computation, University of California, Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"University of California,Santa Barbara,","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5097723089"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":null,"apc_paid":null,"fwci":0.5236,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.65641773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1299","last_page":"1304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9354000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moment-closure","display_name":"Moment closure","score":0.7703824639320374},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6006585359573364},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5408033132553101},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.524077832698822},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4846358895301819},{"id":"https://openalex.org/keywords/moment","display_name":"Moment (physics)","score":0.4838782548904419},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.404615193605423},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3852658271789551},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.36496609449386597},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3388674259185791},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33063286542892456},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30737489461898804},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2943773865699768},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.09395632147789001},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09110578894615173},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.08476588129997253},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.07955244183540344}],"concepts":[{"id":"https://openalex.org/C2778513689","wikidata":"https://www.wikidata.org/wiki/Q6897109","display_name":"Moment closure","level":3,"score":0.7703824639320374},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6006585359573364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5408033132553101},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.524077832698822},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4846358895301819},{"id":"https://openalex.org/C179254644","wikidata":"https://www.wikidata.org/wiki/Q13222844","display_name":"Moment (physics)","level":2,"score":0.4838782548904419},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.404615193605423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3852658271789551},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.36496609449386597},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3388674259185791},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33063286542892456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30737489461898804},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2943773865699768},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.09395632147789001},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09110578894615173},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.08476588129997253},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07955244183540344},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C196558001","wikidata":"https://www.wikidata.org/wiki/Q190132","display_name":"Turbulence","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2007.4282604","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282604","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6299999952316284,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1827189078","https://openalex.org/W1946177469","https://openalex.org/W1978319180","https://openalex.org/W2007500238","https://openalex.org/W2018435536","https://openalex.org/W2032446791","https://openalex.org/W2059053384","https://openalex.org/W2078119846","https://openalex.org/W2078734278","https://openalex.org/W2084924279","https://openalex.org/W2090610011","https://openalex.org/W2102787760","https://openalex.org/W2111167674","https://openalex.org/W2150055571","https://openalex.org/W2164595897","https://openalex.org/W3008437073","https://openalex.org/W6774395789"],"related_works":["https://openalex.org/W2155202381","https://openalex.org/W1851800418","https://openalex.org/W2121476007","https://openalex.org/W2148554623","https://openalex.org/W1421289071","https://openalex.org/W2164786588","https://openalex.org/W2095125040","https://openalex.org/W2735043428","https://openalex.org/W2782848073","https://openalex.org/W2027651914"],"abstract_inverted_index":{"Random":[0],"fluctuations":[1,27,223],"in":[2,31,73,127,136,151,191,202,224,237],"gene":[3,129,133,209,212],"regulatory":[4,130],"networks":[5],"are":[6,28,55],"inevitable":[7],"due":[8],"to":[9,92,124,166,213],"the":[10,17,34,42,46,50,53,58,74,94,105,113,144,152,156,174,204,221,225,228,233,238],"probabilistic":[11],"nature":[12],"of":[13,20,33,41,49,60,70,82,112,183,227,235],"chemical":[14],"reactions":[15],"and":[16,36,162],"small":[18],"populations":[19],"proteins,":[21],"mRNAs":[22,51],"present":[23],"inside":[24],"cells.":[25],"These":[26],"usually":[29],"reported":[30],"terms":[32],"first":[35],"second":[37,216],"order":[38,83,107],"statistical":[39],"moments":[40,62,81,97,108],"protein":[43,139,153,157,205,230],"populations.":[44,154],"If":[45],"birth-death":[47],"rates":[48],"or":[52],"proteins":[54],"nonlinear,":[56],"then":[57],"dynamics":[59],"these":[61,120],"generally":[63],"do":[64],"not":[65,160],"form":[66,167,182],"a":[67,138,197,215],"closed":[68],"system":[69],"differential":[71],"equations,":[72],"sense":[75],"that":[76,178,220],"their":[77,100],"time-derivatives":[78],"depends":[79],"on":[80],"higher":[84,106],"than":[85],"two.":[86],"Recent":[87],"work":[88],"has":[89],"developed":[90],"techniques":[91,123],"obtain":[93],"two":[95,114],"lowest-order":[96],"by":[98,207],"closing":[99],"dynamics,":[101],"which":[102,137,171,203],"involves":[103],"approximating":[104],"as":[109],"nonlinear":[110],"functions":[111],"lowest":[115],"ones.":[116],"This":[117],"paper":[118],"uses":[119],"moment":[121],"closure":[122],"quantify":[125],"noise":[126],"several":[128],"networks.":[131],"In":[132],"expression":[134],"mechanisms":[135],"inhibits":[140,173],"its":[141],"own":[142],"transcription,":[143],"resulting":[145],"negative":[146,184],"feedback":[147,185],"reduces":[148],"stochastic":[149,222],"variations":[150],"Often":[155],"itself":[158,165],"is":[159,188],"active":[161,169],"combines":[163],"with":[164,232],"an":[168],"multimer,":[170],"them":[172],"transcription.":[175],"We":[176,194],"demonstrate":[177],"this":[179],"more":[180,189],"sophisticated":[181],"(using":[186],"multimerization)":[187],"effective":[190],"suppressing":[192],"noise.":[193],"also":[195],"consider":[196],"two-gene":[198],"cascade":[199],"activation":[200],"network":[201],"expressed":[206],"one":[208],"activates":[210],"another":[211],"express":[214],"protein.":[217,240],"Analysis":[218],"shows":[219],"population":[226],"activated":[229],"increases":[231],"degree":[234],"multimerization":[236],"activating":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
