{"id":"https://openalex.org/W2101641437","doi":"https://doi.org/10.1109/acc.2007.4282366","title":"Improving Data Fitting of a Signal Transduction Model by Global Sensitivity Analysis","display_name":"Improving Data Fitting of a Signal Transduction Model by Global Sensitivity Analysis","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2101641437","doi":"https://doi.org/10.1109/acc.2007.4282366","mag":"2101641437"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2007.4282366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101290419","display_name":"Yisu Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yisu Jin","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Central South University, Changsha, China","[Central South University, Changsha]"],"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"[Central South University, Changsha]","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059893133","display_name":"Hong Yue","orcid":"https://orcid.org/0000-0003-2072-6223"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hong Yue","raw_affiliation_strings":["Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","Electronic And Electrical Engineering"],"affiliations":[{"raw_affiliation_string":"Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Electronic And Electrical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022196917","display_name":"Martin M. Brown","orcid":"https://orcid.org/0000-0002-3273-1356"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Brown","raw_affiliation_strings":["School of Electrical and Electronic Engineering, University of Manchester, Institute of Science and Technology, Manchester, UK","School of Electrical and Electronic Engineering, University of Manchester, Manchester M60 1QD. email: martin.brown@manchester.ac.uk"],"affiliations":[{"raw_affiliation_string":"School of Electrical and Electronic Engineering, University of Manchester, Institute of Science and Technology, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Electrical and Electronic Engineering, University of Manchester, Manchester M60 1QD. email: martin.brown@manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087480048","display_name":"Yi\u2010Zeng Liang","orcid":"https://orcid.org/0000-0001-8692-3030"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizeng Liang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Central South University, Changsha, China","College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China. e-mail: yizeng_liang@263.net"],"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China. e-mail: yizeng_liang@263.net","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077370611","display_name":"Douglas B. Kell","orcid":"https://orcid.org/0000-0001-5838-7963"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Douglas B. Kell","raw_affiliation_strings":["Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, 131 Princess St., Manchester M1 7ND, UK. e-mail: dbk@manchester.ac.uk"],"affiliations":[{"raw_affiliation_string":"Manchester Interdisciplinary Biocentre, University of Manchester, Institute of Science and Technology, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, 131 Princess St., Manchester M1 7ND, UK. e-mail: dbk@manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101290419"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":null,"apc_paid":null,"fwci":2.507,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.91012288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"2708","last_page":"2713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9620000123977661,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9074000120162964,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.7656846046447754},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4801875352859497},{"id":"https://openalex.org/keywords/multivariable-calculus","display_name":"Multivariable calculus","score":0.4665610194206238},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.44377392530441284},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4433756470680237},{"id":"https://openalex.org/keywords/transduction","display_name":"Transduction (biophysics)","score":0.43632322549819946},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4033207893371582},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3327072858810425},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.1412954032421112},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1339040994644165},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12524670362472534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11928272247314453},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.08889526128768921}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7656846046447754},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4801875352859497},{"id":"https://openalex.org/C117312493","wikidata":"https://www.wikidata.org/wiki/Q2035437","display_name":"Multivariable calculus","level":2,"score":0.4665610194206238},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.44377392530441284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4433756470680237},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.43632322549819946},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4033207893371582},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3327072858810425},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.1412954032421112},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1339040994644165},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12524670362472534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11928272247314453},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.08889526128768921},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/acc.2007.4282366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:strathprints.strath.ac.uk:36907","is_oa":false,"landing_page_url":"https://strathprints.strath.ac.uk/36907/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"NonPeerReviewed"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W75407940","https://openalex.org/W999207820","https://openalex.org/W1529898704","https://openalex.org/W1550716269","https://openalex.org/W1578017474","https://openalex.org/W1599969036","https://openalex.org/W1641228030","https://openalex.org/W1967225297","https://openalex.org/W1982258483","https://openalex.org/W1996993801","https://openalex.org/W2002629524","https://openalex.org/W2016493615","https://openalex.org/W2017255625","https://openalex.org/W2026647021","https://openalex.org/W2038262676","https://openalex.org/W2039085300","https://openalex.org/W2074097004","https://openalex.org/W2079604837","https://openalex.org/W2093410681","https://openalex.org/W2102486760","https://openalex.org/W2106693245","https://openalex.org/W2108834847","https://openalex.org/W2125937596","https://openalex.org/W2126130288","https://openalex.org/W2131433860","https://openalex.org/W2133554538","https://openalex.org/W2143400799","https://openalex.org/W2165603655","https://openalex.org/W2528271650","https://openalex.org/W2737993238","https://openalex.org/W3011730451","https://openalex.org/W4238726034","https://openalex.org/W4241821011","https://openalex.org/W4256259619","https://openalex.org/W4302328192"],"related_works":["https://openalex.org/W1576377477","https://openalex.org/W2721687755","https://openalex.org/W2224575301","https://openalex.org/W418212511","https://openalex.org/W2388146630","https://openalex.org/W2086932047","https://openalex.org/W2099048101","https://openalex.org/W1964208669","https://openalex.org/W2112363989","https://openalex.org/W13811253"],"abstract_inverted_index":{"Based":[0],"on":[1,27],"a":[2],"simplified":[3],"model":[4,61,81],"of":[5,59,69,96],"the":[6,28,57,60,66,80,83,94],"(TNF-\u03b1":[7],"mediated)":[8],"I\u03baB\u03b1-NF-\u03baB":[9],"signal":[10],"transduction":[11],"pathway,":[12],"global":[13,97],"sensitivity":[14,98],"analysis":[15,99],"has":[16],"been":[17],"performed":[18],"to":[19,39,75,88],"identify":[20],"those":[21,89],"parameters":[22,48],"that":[23,56],"exert":[24],"significant":[25],"control":[26],"system":[29],"outputs.":[30],"The":[31,45],"permutation":[32],"operation":[33],"in":[34,100],"Morris":[35],"method":[36],"is":[37],"modified":[38],"work":[40],"for":[41],"log-uniform":[42],"sampling":[43],"parameters.":[44],"identified":[46],"sensitive":[47],"are":[49],"then":[50],"estimated":[51],"using":[52],"multivariable":[53],"search":[54],"such":[55],"output":[58],"matches":[62],"experimental":[63,84],"data":[64],"representing":[65],"nuclear":[67],"concentration":[68],"NF-kappaB.":[70],"Such":[71],"parameter":[72],"tuning":[73],"leads":[74],"much":[76],"better":[77],"agreement":[78],"between":[79],"and":[82],"time":[85],"series":[86],"relative":[87],"previously":[90],"published.":[91],"This":[92],"shows":[93],"importance":[95],"Systems":[101],"Biology":[102],"models.":[103]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
