{"id":"https://openalex.org/W2106400237","doi":"https://doi.org/10.1109/acc.2007.4282275","title":"Design and Analysis of an Activator-Repressor Clock in E. Coli","display_name":"Design and Analysis of an Activator-Repressor Clock in E. Coli","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2106400237","doi":"https://doi.org/10.1109/acc.2007.4282275","mag":"2106400237"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2007.4282275","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282275","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036095256","display_name":"Domitilla Del Vecchio","orcid":"https://orcid.org/0000-0001-6472-8576"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D. Del Vecchio","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036095256"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0723,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.76052731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1589","last_page":"1594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repressor","display_name":"Repressor","score":0.8716118335723877},{"id":"https://openalex.org/keywords/activator","display_name":"Activator (genetics)","score":0.7427445650100708},{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.4334383010864258},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.42800575494766235},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4107038974761963},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3989531099796295},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.33416110277175903},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.30815547704696655},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23198887705802917},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15872016549110413},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14947769045829773},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1280619502067566},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.12004202604293823}],"concepts":[{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.8716118335723877},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.7427445650100708},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.4334383010864258},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.42800575494766235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4107038974761963},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3989531099796295},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.33416110277175903},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30815547704696655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23198887705802917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15872016549110413},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14947769045829773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1280619502067566},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12004202604293823},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2007.4282275","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2007.4282275","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 American Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1599969036","https://openalex.org/W2014150977","https://openalex.org/W2037992356","https://openalex.org/W2065949669","https://openalex.org/W2083117595","https://openalex.org/W2115908440","https://openalex.org/W2123097315","https://openalex.org/W4231409469","https://openalex.org/W4293079218"],"related_works":["https://openalex.org/W3100859731","https://openalex.org/W2157865104","https://openalex.org/W2166977752","https://openalex.org/W87952807","https://openalex.org/W2140908476","https://openalex.org/W2106400237","https://openalex.org/W2797015333","https://openalex.org/W4353113173","https://openalex.org/W2166990188","https://openalex.org/W2162884852"],"abstract_inverted_index":{"We":[0,21],"analyze":[1],"a":[2,11,34],"model":[3],"for":[4,75],"the":[5,16,25,29,42,46,76],"activator-repressor":[6,80],"oscillator":[7],"motif":[8,14],"proposed":[9,55],"as":[10,72],"fundamental":[12],"oscillating":[13],"in":[15,28,45],"literature":[17,47],"of":[18,78],"biological":[19],"rhythms.":[20],"show":[22],"that":[23,63],"incorporating":[24],"m-RNA":[26],"dynamics":[27,51],"model,":[30],"we":[31],"can":[32,69],"obtain":[33],"much":[35],"richer":[36],"dynamical":[37],"behavior":[38],"with":[39],"respect":[40],"to":[41,59],"behaviors":[43],"observed":[44],"when":[48],"only":[49],"protein":[50],"were":[52],"modeled.":[53],"The":[54],"analysis":[56],"also":[57],"leads":[58],"biochemical":[60],"parameter":[61],"relationships":[62,68],"guarantee":[64],"stable":[65],"oscillations.":[66],"These":[67],"be":[70],"used":[71],"design":[73],"guidelines":[74],"construction":[77],"synthetic":[79],"oscillators.":[81]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2025-10-10T00:00:00"}