{"id":"https://openalex.org/W2103087343","doi":"https://doi.org/10.1109/acc.2003.1243380","title":"Hierarchical cluster analysis to detect coordinated protein expression in metabolically engineered Zymomonas mobilis","display_name":"Hierarchical cluster analysis to detect coordinated protein expression in metabolically engineered Zymomonas mobilis","publication_year":2004,"publication_date":"2004-02-03","ids":{"openalex":"https://openalex.org/W2103087343","doi":"https://doi.org/10.1109/acc.2003.1243380","mag":"2103087343"},"language":"en","primary_location":{"id":"doi:10.1109/acc.2003.1243380","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2003.1243380","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2003 American Control Conference, 2003.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011858847","display_name":"David B. Hodge","orcid":"https://orcid.org/0000-0002-9313-941X"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Hodge","raw_affiliation_strings":["Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003734787","display_name":"M. Nazmul Karim","orcid":"https://orcid.org/0000-0002-0332-4217"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Karim","raw_affiliation_strings":["Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031585152","display_name":"Kenneth F. Reardon","orcid":"https://orcid.org/0000-0002-7753-4049"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.F. Reardon","raw_affiliation_strings":["Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. of Chem. Eng., Colorado State Univ., Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11066847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"2081","last_page":"2082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zymomonas-mobilis","display_name":"Zymomonas mobilis","score":0.9836349487304688},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"Pentose phosphate pathway","score":0.668144166469574},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5842456817626953},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.5389713644981384},{"id":"https://openalex.org/keywords/protein-expression","display_name":"Protein expression","score":0.48911505937576294},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.460126131772995},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.4447658956050873},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41680243611335754},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3951050043106079},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3856383264064789},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3727070093154907},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2247903048992157},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.20862418413162231},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.060530513525009155}],"concepts":[{"id":"https://openalex.org/C2780604136","wikidata":"https://www.wikidata.org/wiki/Q245744","display_name":"Zymomonas mobilis","level":4,"score":0.9836349487304688},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.668144166469574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5842456817626953},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5389713644981384},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.48911505937576294},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.460126131772995},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4447658956050873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41680243611335754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3951050043106079},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3856383264064789},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3727070093154907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2247903048992157},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.20862418413162231},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.060530513525009155},{"id":"https://openalex.org/C65183824","wikidata":"https://www.wikidata.org/wiki/Q194361","display_name":"Ethanol fuel","level":3,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/acc.2003.1243380","is_oa":false,"landing_page_url":"https://doi.org/10.1109/acc.2003.1243380","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2003 American Control Conference, 2003.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1773438532","https://openalex.org/W1987648128","https://openalex.org/W2066320604","https://openalex.org/W2096642289","https://openalex.org/W2106474402","https://openalex.org/W2150926065","https://openalex.org/W2159615937"],"related_works":["https://openalex.org/W610932502","https://openalex.org/W3028073815","https://openalex.org/W2079755951","https://openalex.org/W2082055828","https://openalex.org/W2021444795","https://openalex.org/W1979707090","https://openalex.org/W2507434834","https://openalex.org/W2390291333","https://openalex.org/W1773438532","https://openalex.org/W2058712067"],"abstract_inverted_index":{"Two":[0],"dimensional":[1],"gel":[2],"electrophoresis":[3],"(2-DE)":[4],"was":[5],"used":[6],"to":[7,26],"profile":[8],"protein":[9,28],"expression":[10,29,38],"patterns":[11,30],"in":[12],"a":[13,66,71],"metabolically":[14],"engineered":[15],"Zymomonas":[16],"mobilis":[17],"strain.":[18],"An":[19],"application":[20],"of":[21,45,73,76],"the":[22,74,77],"hierarchical":[23],"cluster":[24],"analysis":[25],"dynamic":[27],"determined":[31],"that":[32],"functionally":[33,42],"related":[34,43],"proteins":[35,46],"show":[36],"similar":[37],"trajectories.":[39],"The":[40],"three":[41],"classes":[44],"include:":[47],"Entner-Douderoff":[48],"(ED)":[49],"and":[50,60],"fermentative":[51],"pathway":[52,58],"enzymes,":[53,59],"recombinant":[54],"pentose":[55],"phosphate":[56],"(PP)":[57],"stress":[61,68],"proteins.":[62],"Findings":[63],"included":[64],"identifying":[65],"cellular":[67],"response":[69],"as":[70],"result":[72],"utilization":[75],"foreign":[78],"metabolic":[79],"pathway.":[80]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}