{"id":"https://openalex.org/W2126278766","doi":"https://doi.org/10.1109/.2005.1467069","title":"Non-Linear Model Reduction for Metabolic Networks with Multiple Time-Scales","display_name":"Non-Linear Model Reduction for Metabolic Networks with Multiple Time-Scales","publication_year":2005,"publication_date":"2005-07-27","ids":{"openalex":"https://openalex.org/W2126278766","doi":"https://doi.org/10.1109/.2005.1467069","mag":"2126278766"},"language":"en","primary_location":{"id":"doi:10.1109/.2005.1467069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/.2005.1467069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2005 IEEE International Symposium on, Mediterrean Conference on Control and Automation Intelligent Control, 2005.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061528180","display_name":"Ziomara P. Gerdtzen","orcid":"https://orcid.org/0000-0002-7486-8537"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Z.P. Gerdtzen","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030294470","display_name":"Pr\u00f3dromos Daoutidis","orcid":"https://orcid.org/0000-0003-4803-0404"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Daoutidis","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053350067","display_name":"Wei\u2010Shou Hu","orcid":"https://orcid.org/0000-0002-5964-2900"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Shou Hu","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Dept. of Chem. Eng. & Mater. Sci., Minnesota Univ., Minneapolis, MN#TAB#","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061528180"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19638969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":null,"first_page":"519","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10553","display_name":"Combustion and flame dynamics","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10553","display_name":"Combustion and flame dynamics","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.9621000289916992,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/singular-perturbation","display_name":"Singular perturbation","score":0.7195743322372437},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.7047021985054016},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.6073957681655884},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5235148072242737},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.4690295457839966},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.45460623502731323},{"id":"https://openalex.org/keywords/nonlinear-dynamical-systems","display_name":"Nonlinear dynamical systems","score":0.43297091126441956},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.417081356048584},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3986528813838959},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.35741639137268066},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.343474417924881},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.34282976388931274},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.32764625549316406},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.15549242496490479},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13695645332336426},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09503880143165588},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07309350371360779}],"concepts":[{"id":"https://openalex.org/C165160513","wikidata":"https://www.wikidata.org/wiki/Q7524249","display_name":"Singular perturbation","level":2,"score":0.7195743322372437},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.7047021985054016},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.6073957681655884},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5235148072242737},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.4690295457839966},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.45460623502731323},{"id":"https://openalex.org/C2983030100","wikidata":"https://www.wikidata.org/wiki/Q638328","display_name":"Nonlinear dynamical systems","level":3,"score":0.43297091126441956},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.417081356048584},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3986528813838959},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35741639137268066},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.343474417924881},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.34282976388931274},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.32764625549316406},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15549242496490479},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13695645332336426},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09503880143165588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07309350371360779},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/.2005.1467069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/.2005.1467069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2005 IEEE International Symposium on, Mediterrean Conference on Control and Automation Intelligent Control, 2005.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1515224583","https://openalex.org/W1981591515","https://openalex.org/W2007728693","https://openalex.org/W2059145118","https://openalex.org/W2075835338","https://openalex.org/W2105736780","https://openalex.org/W2417790885"],"related_works":["https://openalex.org/W2055379029","https://openalex.org/W2011339542","https://openalex.org/W2532234348","https://openalex.org/W2387203662","https://openalex.org/W4327639758","https://openalex.org/W2116787190","https://openalex.org/W2154304710","https://openalex.org/W2623488306","https://openalex.org/W1971902905","https://openalex.org/W2006371715"],"abstract_inverted_index":{"We":[0],"present":[1],"a":[2,50],"method":[3,21,45],"for":[4,10],"obtaining":[5],"non-stiff":[6],"nonlinear":[7],"reduced-order":[8],"models":[9],"metabolic":[11],"networks,":[12],"which":[13],"exhibit":[14],"dynamics":[15],"in":[16,57],"multiple":[17],"time":[18,36],"scales.":[19],"The":[20,44],"is":[22,46],"based":[23],"on":[24],"the":[25,34,41],"successive":[26],"application":[27],"of":[28,53],"singular":[29],"perturbation":[30],"arguments,":[31],"starting":[32],"from":[33],"fastest":[35],"scale":[37],"and":[38],"proceeding":[39],"to":[40,49],"slowest":[42],"one.":[43],"successfully":[47],"applied":[48],"detailed":[51],"model":[52],"central":[54],"carbon":[55],"metabolism":[56],"human":[58],"erythrocytes":[59]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}