{"id":"https://openalex.org/W2001577294","doi":"https://doi.org/10.1108/03684920910962623","title":"Modelling and mathematical studies of neuronal NO\u2010synthase: NO versus NA theory","display_name":"Modelling and mathematical studies of neuronal NO\u2010synthase: NO versus NA theory","publication_year":2009,"publication_date":"2009-06-12","ids":{"openalex":"https://openalex.org/W2001577294","doi":"https://doi.org/10.1108/03684920910962623","mag":"2001577294"},"language":"en","primary_location":{"id":"doi:10.1108/03684920910962623","is_oa":false,"landing_page_url":"https://doi.org/10.1108/03684920910962623","pdf_url":null,"source":{"id":"https://openalex.org/S168682784","display_name":"Kybernetes","issn_l":"0368-492X","issn":["0368-492X","1758-7883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319811","host_organization_name":"Emerald Publishing Limited","host_organization_lineage":["https://openalex.org/P4310319811"],"host_organization_lineage_names":["Emerald Publishing Limited"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kybernetes","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079714002","display_name":"S. Guellal","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125635","display_name":"Institut catholique d\u2019\u00e9tudes sup\u00e9rieures","ror":"https://ror.org/02tqmhd47","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210125635"]},{"id":"https://openalex.org/I4210107416","display_name":"Roche (France)","ror":"https://ror.org/01mqmer16","country_code":"FR","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210107416"]},{"id":"https://openalex.org/I55921689","display_name":"La Roche College","ror":"https://ror.org/04bthcb08","country_code":"US","type":"education","lineage":["https://openalex.org/I55921689"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Sa\u00efd Guellal","raw_affiliation_strings":["ICES \u2013 L'Ecole Universitaire, La Roche sur Yon, France","(ICES \u2013 L'Ecole Universitaire, La Roche sur Yon, France)"],"affiliations":[{"raw_affiliation_string":"ICES \u2013 L'Ecole Universitaire, La Roche sur Yon, France","institution_ids":["https://openalex.org/I4210125635","https://openalex.org/I4210107416"]},{"raw_affiliation_string":"(ICES \u2013 L'Ecole Universitaire, La Roche sur Yon, France)","institution_ids":["https://openalex.org/I55921689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066853452","display_name":"A. Meulemans","orcid":null},"institutions":[{"id":"https://openalex.org/I4210133833","display_name":"H\u00f4pital Xavier Arnozan","ror":"https://ror.org/03d532p87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210133833"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Meulemans","raw_affiliation_strings":["Laboratoire de biophysique, Facult\u00e9 de M\u00e9decine Xavier\u2010Bichat, Paris, France","(Laboratoire de biophysique, Facult\u00e9 de M\u00e9decine Xavier\u2010Bichat, Paris, France)"],"affiliations":[{"raw_affiliation_string":"Laboratoire de biophysique, Facult\u00e9 de M\u00e9decine Xavier\u2010Bichat, Paris, France","institution_ids":["https://openalex.org/I4210133833"]},{"raw_affiliation_string":"(Laboratoire de biophysique, Facult\u00e9 de M\u00e9decine Xavier\u2010Bichat, Paris, France)","institution_ids":["https://openalex.org/I4210133833"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008840225","display_name":"S. Khelifa","orcid":null},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Salim Khelifa","raw_affiliation_strings":["Facult\u00e9 de Math\u00e9matiques, Universit\u00e9 des Sciences et de la Technologie Houari Boumediene, Alger, Algeria","(Facult\u00e9 de Math\u00e9matiques, Universit\u00e9 des Sciences et de la Technologie Houari Boumediene, Alger, Algeria)"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de Math\u00e9matiques, Universit\u00e9 des Sciences et de la Technologie Houari Boumediene, Alger, Algeria","institution_ids":["https://openalex.org/I157169809"]},{"raw_affiliation_string":"(Facult\u00e9 de Math\u00e9matiques, Universit\u00e9 des Sciences et de la Technologie Houari Boumediene, Alger, Algeria)","institution_ids":["https://openalex.org/I157169809"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079714002"],"corresponding_institution_ids":["https://openalex.org/I4210107416","https://openalex.org/I4210125635","https://openalex.org/I55921689"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1030707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"5","first_page":"725","last_page":"732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.955299973487854,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"Nitric oxide synthase","score":0.6185747981071472},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.49490422010421753},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.4865371286869049},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.4748278558254242},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.45008817315101624},{"id":"https://openalex.org/keywords/value","display_name":"Value (mathematics)","score":0.44923973083496094},{"id":"https://openalex.org/keywords/originality","display_name":"Originality","score":0.4490009546279907},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35209494829177856},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31523531675338745},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2898705005645752},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.245619535446167},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13532805442810059},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.12598338723182678},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.09801623225212097},{"id":"https://openalex.org/keywords/social-psychology","display_name":"Social psychology","score":0.09342661499977112}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6185747981071472},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49490422010421753},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.4865371286869049},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4748278558254242},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45008817315101624},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.44923973083496094},{"id":"https://openalex.org/C2776950860","wikidata":"https://www.wikidata.org/wiki/Q2914681","display_name":"Originality","level":3,"score":0.4490009546279907},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35209494829177856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31523531675338745},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2898705005645752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.245619535446167},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13532805442810059},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.12598338723182678},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.09801623225212097},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.09342661499977112},{"id":"https://openalex.org/C11012388","wikidata":"https://www.wikidata.org/wiki/Q170658","display_name":"Creativity","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1108/03684920910962623","is_oa":false,"landing_page_url":"https://doi.org/10.1108/03684920910962623","pdf_url":null,"source":{"id":"https://openalex.org/S168682784","display_name":"Kybernetes","issn_l":"0368-492X","issn":["0368-492X","1758-7883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319811","host_organization_name":"Emerald Publishing Limited","host_organization_lineage":["https://openalex.org/P4310319811"],"host_organization_lineage_names":["Emerald Publishing Limited"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kybernetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1516552836","https://openalex.org/W1552614411","https://openalex.org/W1570106084","https://openalex.org/W1580458380","https://openalex.org/W1869042642","https://openalex.org/W1970548686","https://openalex.org/W1982541458","https://openalex.org/W2042443984","https://openalex.org/W2043342811","https://openalex.org/W2046712488","https://openalex.org/W2051106202","https://openalex.org/W4240384253"],"related_works":["https://openalex.org/W2593155302","https://openalex.org/W2041415459","https://openalex.org/W3126095231","https://openalex.org/W2072812638","https://openalex.org/W2352855287","https://openalex.org/W2378906650","https://openalex.org/W2384288445","https://openalex.org/W2382526412","https://openalex.org/W4200071106","https://openalex.org/W2347474189"],"abstract_inverted_index":{"Purpose":[0],"The":[1,78,96],"purpose":[2],"of":[3,13,49,89,99,109,117],"this":[4],"paper":[5,97],"is":[6,98,104],"to":[7,80,85],"present":[8],"modelling":[9],"and":[10,16,35,46,51,73,112],"mathematical":[11],"studies":[12],"neuronal":[14],"NO\u2010synthase":[15,88],"discuss":[17],"the":[18,36,41,52,82,87,90,105,113],"case":[19],"for":[20],"nitric":[21],"oxide":[22],"(NO)":[23],"versus":[24],"nitroso\u2010arginine":[25],"(NA)":[26],"theory.":[27],"Design/methodology/approach":[28],"Introduces":[29],"recent":[30],"studies,":[31,69],"NO":[32],"studied":[33],"models":[34],"experimental":[37],"model":[38],"before":[39],"considering":[40],"diffusion\u2010reaction":[42],"model.":[43],"Enzymatic":[44],"kinetics":[45],"an":[47],"analysis":[48],"systems":[50],"NA":[53],"diffusion":[54],"equations":[55],"in":[56,119],"mice":[57],"cortex":[58],"are":[59,63,76],"given.":[60,77],"Numerical":[61],"results":[62],"featured.":[64],"Findings":[65],"Based":[66],"on":[67],"these":[68],"both":[70],"a":[71,93,130],"bio\u2010mathematical":[72],"physiological":[74],"conclusions":[75],"way":[79],"protect":[81],"brain":[83],"was":[84],"inhibit":[86],"neurons":[91],"during":[92],"stroke.":[94,131],"Originality/value":[95],"value,":[100],"particularly":[101],"as":[102],"stroke":[103],"second":[106],"leading":[107],"cause":[108,116],"mortality":[110],"worldwide":[111],"most":[114],"common":[115],"dementia":[118],"western":[120],"countries.":[121],"In":[122],"Europe,":[123],"each":[124],"year,":[125],"over":[126],"1,200,000":[127],"people":[128],"experience":[129]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}