{"id":"https://openalex.org/W2202954603","doi":"https://doi.org/10.1093/nar/gkv1165","title":"DGIdb 2.0: mining clinically relevant drug\u2013gene interactions","display_name":"DGIdb 2.0: mining clinically relevant drug\u2013gene interactions","publication_year":2015,"publication_date":"2015-11-03","ids":{"openalex":"https://openalex.org/W2202954603","doi":"https://doi.org/10.1093/nar/gkv1165","mag":"2202954603","pmid":"https://pubmed.ncbi.nlm.nih.gov/26531824"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkv1165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv1165","pdf_url":"https://academic.oup.com/nar/article-pdf/44/D1/D1036/16661555/gkv1165.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/44/D1/D1036/16661555/gkv1165.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041447016","display_name":"Alex H. Wagner","orcid":"https://orcid.org/0000-0002-2502-8961"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex H. Wagner","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102919636","display_name":"Adam Coffman","orcid":"https://orcid.org/0000-0003-0944-3126"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam C. Coffman","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003910116","display_name":"Benjamin J. Ainscough","orcid":"https://orcid.org/0000-0001-8340-514X"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Ainscough","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058907044","display_name":"Nicholas C. Spies","orcid":"https://orcid.org/0000-0002-5873-351X"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas C. Spies","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049794515","display_name":"Zachary L. Skidmore","orcid":"https://orcid.org/0000-0003-1928-7139"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary L. Skidmore","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052134884","display_name":"Katie M. Campbell","orcid":"https://orcid.org/0000-0001-6491-4432"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie M. Campbell","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067266092","display_name":"Kilannin Krysiak","orcid":"https://orcid.org/0000-0002-6299-9230"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kilannin Krysiak","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030112824","display_name":"Deng Pan","orcid":"https://orcid.org/0000-0002-7061-9744"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deng Pan","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078124570","display_name":"Joshua F. McMichael","orcid":"https://orcid.org/0000-0002-0197-2245"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua F. McMichael","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039744856","display_name":"James M. Eldred","orcid":null},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Eldred","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057508602","display_name":"Jason Walker","orcid":"https://orcid.org/0000-0001-7547-5789"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R. Walker","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014714324","display_name":"Richard K. Wilson","orcid":"https://orcid.org/0000-0002-1992-1358"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. Wilson","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054642128","display_name":"Elaine R. Mardis","orcid":"https://orcid.org/0000-0002-5892-1553"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine R. Mardis","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035700326","display_name":"Malachi Griffith","orcid":"https://orcid.org/0000-0002-6388-446X"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malachi Griffith","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA mgriffit@genome.wustl.edu","Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA mgriffit@genome.wustl.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001076376","display_name":"Obi L. Griffith","orcid":"https://orcid.org/0000-0002-0843-4271"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Obi L. Griffith","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA ogriffit@genome.wustl.edu","McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA ogriffit@genome.wustl.edu","institution_ids":[]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA","institution_ids":["https://openalex.org/I114277686"]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5041447016"],"corresponding_institution_ids":["https://openalex.org/I114277686"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":52.9278,"has_fulltext":true,"cited_by_count":447,"citation_normalized_percentile":{"value":0.99911032,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"44","issue":"D1","first_page":"D1036","last_page":"D1044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.8852214813232422},{"id":"https://openalex.org/keywords/identifier","display_name":"Identifier","score":0.573182225227356},{"id":"https://openalex.org/keywords/application-programming-interface","display_name":"Application programming interface","score":0.568888783454895},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.5643869042396545},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.4621954560279846},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4578506052494049},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4480918049812317},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43820756673812866},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4224950969219208},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3812105655670166},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3707779049873352},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12412741780281067}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.8852214813232422},{"id":"https://openalex.org/C154504017","wikidata":"https://www.wikidata.org/wiki/Q853614","display_name":"Identifier","level":2,"score":0.573182225227356},{"id":"https://openalex.org/C99613125","wikidata":"https://www.wikidata.org/wiki/Q165194","display_name":"Application programming interface","level":2,"score":0.568888783454895},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.5643869042396545},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.4621954560279846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4578506052494049},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4480918049812317},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43820756673812866},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4224950969219208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3812105655670166},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3707779049873352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12412741780281067},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C55352822","wikidata":"https://www.wikidata.org/wiki/Q5558978","display_name":"Gibbs isotherm","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkv1165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv1165","pdf_url":"https://academic.oup.com/nar/article-pdf/44/D1/D1036/16661555/gkv1165.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:26531824","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26531824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5385","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4379","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=5385&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:3680754","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4702839","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:nar:44/D1/D1036","is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/44/D1/D1036","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4702839","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkv1165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkv1165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv1165","pdf_url":"https://academic.oup.com/nar/article-pdf/44/D1/D1036/16661555/gkv1165.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2202954603.pdf","grobid_xml":"https://content.openalex.org/works/W2202954603.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W192069810","https://openalex.org/W223909586","https://openalex.org/W1490161904","https://openalex.org/W1506364563","https://openalex.org/W1545144560","https://openalex.org/W1601495365","https://openalex.org/W1970219158","https://openalex.org/W1971825415","https://openalex.org/W1975875968","https://openalex.org/W1983248350","https://openalex.org/W1996832454","https://openalex.org/W2011138994","https://openalex.org/W2012750155","https://openalex.org/W2014522837","https://openalex.org/W2018518196","https://openalex.org/W2022495797","https://openalex.org/W2029335938","https://openalex.org/W2052250375","https://openalex.org/W2060427373","https://openalex.org/W2066412407","https://openalex.org/W2074370114","https://openalex.org/W2075204007","https://openalex.org/W2098738258","https://openalex.org/W2109108939","https://openalex.org/W2113534011","https://openalex.org/W2124796057","https://openalex.org/W2130940380","https://openalex.org/W2141432783","https://openalex.org/W2147241078","https://openalex.org/W2159265519","https://openalex.org/W2160860814","https://openalex.org/W3101707886","https://openalex.org/W4230266413"],"related_works":["https://openalex.org/W2556855892","https://openalex.org/W4214810602","https://openalex.org/W2523769397","https://openalex.org/W2000687555","https://openalex.org/W1969888071","https://openalex.org/W2035422779","https://openalex.org/W2925167008","https://openalex.org/W3023385275","https://openalex.org/W2008033400","https://openalex.org/W1972982874"],"abstract_inverted_index":{"The":[0,112],"Drug-Gene":[1],"Interaction":[2],"Database":[3],"(DGIdb,":[4],"www.dgidb.org)":[5],"is":[6],"a":[7,29,71,125,140,152,180],"web":[8,154],"resource":[9,72],"that":[10],"consolidates":[11],"disparate":[12],"data":[13],"sources":[14,82,131],"describing":[15],"drug-gene":[16,84,110],"interactions":[17,85,95,165],"and":[18,28,66,156,182],"gene":[19,117],"druggability.":[20],"It":[21],"provides":[22],"an":[23,43],"intuitive":[24],"graphical":[25],"user":[26,183],"interface":[27,33],"documented":[30],"application":[31],"programming":[32],"(API)":[34],"for":[35,73,148,164,186,191],"querying":[36],"these":[37,149,176],"data.":[38],"DGIdb":[39,56,134,178],"was":[40],"assembled":[41],"through":[42],"extensive":[44],"manual":[45],"curation":[46],"effort,":[47],"reflecting":[48],"the":[49,106,128,144,188],"combined":[50],"information":[51,147],"of":[52,83,109,115,127],"twenty-seven":[53],"sources.":[54,150],"For":[55],"2.0,":[57],"substantial":[58],"updates":[59],"have":[60,86,102,158],"been":[61,87,159],"made":[62],"to":[63,97,161,169],"increase":[64],"content":[65],"improve":[67],"its":[68],"usefulness":[69],"as":[70],"mining":[74,187],"clinically":[75],"actionable":[76],"drug":[77,167],"targets.":[78],"Specifically,":[79],"nine":[80],"new":[81,153],"added,":[88],"including":[89],"seven":[90],"resources":[91],"specifically":[92],"focused":[93],"on":[94,139],"linked":[96],"clinical":[98],"trials.":[99],"These":[100],"additions":[101],"more":[103],"than":[104],"doubled":[105],"overall":[107],"count":[108],"interactions.":[111],"total":[113],"number":[114],"druggable":[116,189],"claims":[118],"has":[119],"also":[120],"increased":[121],"by":[122,166],"30%.":[123],"Importantly,":[124],"majority":[126],"unrestricted,":[129],"publicly-accessible":[130],"used":[132],"in":[133],"are":[135],"now":[136],"automatically":[137],"updated":[138],"weekly":[141],"basis,":[142],"providing":[143],"most":[145],"current":[146],"Finally,":[151],"view":[155],"API":[157],"developed":[160],"allow":[162],"searching":[163],"identifiers":[168],"complement":[170],"existing":[171],"gene-based":[172],"search":[173],"functionality.":[174],"With":[175],"updates,":[177],"represents":[179],"comprehensive":[181],"friendly":[184],"tool":[185],"genome":[190],"precision":[192],"medicine":[193],"hypothesis":[194],"generation.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":42},{"year":2024,"cited_by_count":45},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":54},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":56},{"year":2017,"cited_by_count":69},{"year":2016,"cited_by_count":26}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}