{"id":"https://openalex.org/W2098967508","doi":"https://doi.org/10.1093/nar/gku476","title":"LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures","display_name":"LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures","publication_year":2014,"publication_date":"2014-06-06","ids":{"openalex":"https://openalex.org/W2098967508","doi":"https://doi.org/10.1093/nar/gku476","mag":"2098967508","pmid":"https://pubmed.ncbi.nlm.nih.gov/24906883"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku476","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku476","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W449/17423942/gku476.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/W1/W449/17423942/gku476.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018902285","display_name":"Qiaonan Duan","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qiaonan Duan","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063882098","display_name":"Corey Flynn","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey Flynn","raw_affiliation_strings":["Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA"],"affiliations":[{"raw_affiliation_string":"Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040454293","display_name":"Mario Niepel","orcid":"https://orcid.org/0000-0003-1415-6295"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Niepel","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA - 02115, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA - 02115, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018837401","display_name":"Marc Hafner","orcid":"https://orcid.org/0000-0003-1337-7598"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Hafner","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008170279","display_name":"Jeremy L. Muhlich","orcid":"https://orcid.org/0000-0002-0811-637X"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy L. Muhlich","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102932473","display_name":"Nicolas Fernandez","orcid":"https://orcid.org/0000-0001-7979-2941"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas F. Fernandez","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007100650","display_name":"Andrew D. Rouillard","orcid":"https://orcid.org/0000-0002-3502-7161"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Rouillard","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081127970","display_name":"Christopher M. Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Tan","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046028362","display_name":"Edward Y. Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Y. Chen","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001449157","display_name":"Todd R. Golub","orcid":"https://orcid.org/0000-0003-0113-2403"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd R. Golub","raw_affiliation_strings":["Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","2Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA"],"affiliations":[{"raw_affiliation_string":"Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"2Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063426870","display_name":"Peter K. Sorger","orcid":"https://orcid.org/0000-0002-3364-1838"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K. Sorger","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109532899","display_name":"Aravind Subramanian","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aravind Subramanian","raw_affiliation_strings":["Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","2Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA"],"affiliations":[{"raw_affiliation_string":"Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"2Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032951414","display_name":"Avi Ma\u2019ayan","orcid":"https://orcid.org/0000-0002-6904-1017"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Ma'ayan","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA avi.maayan@mssm.edu","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA avi.maayan@mssm.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Systems Biology Center New York (SBCNY), One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5018902285"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":13.4043,"has_fulltext":true,"cited_by_count":338,"citation_normalized_percentile":{"value":0.99286593,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"42","issue":"W1","first_page":"W449","last_page":"W460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7031663656234741},{"id":"https://openalex.org/keywords/html5","display_name":"HTML5","score":0.4840542674064636},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4649713337421417},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4269689917564392},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.42222288250923157},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.39626938104629517},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3783884346485138},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3547884225845337},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2986084222793579},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18229568004608154}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7031663656234741},{"id":"https://openalex.org/C84063617","wikidata":"https://www.wikidata.org/wiki/Q2053","display_name":"HTML5","level":2,"score":0.4840542674064636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4649713337421417},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4269689917564392},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.42222288250923157},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.39626938104629517},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3783884346485138},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3547884225845337},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2986084222793579},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18229568004608154},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gku476","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku476","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W449/17423942/gku476.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:24906883","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24906883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4086130","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4086130","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:6403294","is_oa":true,"landing_page_url":"https://zenodo.org/record/6403294","pdf_url":"https://zenodo.org/record/6403294","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dash.harvard.edu:1/13581236","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581236","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gku476","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku476","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W449/17423942/gku476.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1936110908","display_name":null,"funder_award_id":"P50GM071558","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7995854210","display_name":null,"funder_award_id":"U54HG006093","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8391552583","display_name":null,"funder_award_id":"098316","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8862761336","display_name":null,"funder_award_id":"GM071558","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098967508.pdf","grobid_xml":"https://content.openalex.org/works/W2098967508.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1679913846","https://openalex.org/W1957390836","https://openalex.org/W1980548655","https://openalex.org/W1988377311","https://openalex.org/W1992806088","https://openalex.org/W1993026721","https://openalex.org/W1997921822","https://openalex.org/W2007114975","https://openalex.org/W2010502047","https://openalex.org/W2027844138","https://openalex.org/W2027895157","https://openalex.org/W2029980980","https://openalex.org/W2043398720","https://openalex.org/W2051018563","https://openalex.org/W2051047800","https://openalex.org/W2055801225","https://openalex.org/W2058302635","https://openalex.org/W2064711537","https://openalex.org/W2070050178","https://openalex.org/W2093424424","https://openalex.org/W2093651950","https://openalex.org/W2098023402","https://openalex.org/W2105721964","https://openalex.org/W2108559088","https://openalex.org/W2108883386","https://openalex.org/W2110065044","https://openalex.org/W2110350344","https://openalex.org/W2110751128","https://openalex.org/W2121604817","https://openalex.org/W2124388496","https://openalex.org/W2124486107","https://openalex.org/W2124954099","https://openalex.org/W2126371198","https://openalex.org/W2130410032","https://openalex.org/W2133465414","https://openalex.org/W2135415614","https://openalex.org/W2137632714","https://openalex.org/W2147714160","https://openalex.org/W2148345265","https://openalex.org/W2149248356","https://openalex.org/W2149601257","https://openalex.org/W2150926065","https://openalex.org/W2154362705","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2164056737","https://openalex.org/W2165275387","https://openalex.org/W2169622100","https://openalex.org/W2290195878","https://openalex.org/W2318564252","https://openalex.org/W2481466480","https://openalex.org/W2899740253","https://openalex.org/W3101608900","https://openalex.org/W4213088479","https://openalex.org/W4242404314","https://openalex.org/W4245176872","https://openalex.org/W4294216483","https://openalex.org/W6674099526","https://openalex.org/W6676591658","https://openalex.org/W6676792427","https://openalex.org/W6679628609","https://openalex.org/W6682206525","https://openalex.org/W6684156543","https://openalex.org/W6721881584","https://openalex.org/W6785415648"],"related_works":["https://openalex.org/W2738171917","https://openalex.org/W2800367462","https://openalex.org/W2157797675","https://openalex.org/W2394595315","https://openalex.org/W573474312","https://openalex.org/W2254189936","https://openalex.org/W2486679002","https://openalex.org/W2922249712","https://openalex.org/W2292214726","https://openalex.org/W2338087908"],"abstract_inverted_index":{"For":[0],"the":[1,15,54,74,96,101,123,159],"Library":[2],"of":[3,53,158],"Integrated":[4],"Network-based":[5],"Cellular":[6],"Signatures":[7],"(LINCS)":[8],"project":[9],"many":[10,52,130],"gene":[11,30,84,111],"expression":[12,31,71],"signatures":[13],"using":[14,81],"L1000":[16,22,58,70],"technology":[17,23],"have":[18],"been":[19],"produced.":[20],"The":[21,127,145],"is":[24,39,148],"a":[25],"cost-effective":[26],"method":[27],"to":[28,67,76,109,121],"profile":[29],"in":[32,139],"large":[33],"scale.":[34],"LINCS":[35,57],"Canvas":[36],"Browser":[37],"(LCB)":[38],"an":[40,89,133],"interactive":[41],"HTML5":[42],"web-based":[43],"software":[44],"application":[45,147],"that":[46],"facilitates":[47],"querying,":[48],"browsing":[49],"and":[50,73,113,142,161],"interrogating":[51],"currently":[55],"available":[56,149],"data.":[59],"LCB":[60,146],"implements":[61],"two":[62],"compacted":[63],"layered":[64],"canvases,":[65],"one":[66],"visualize":[68],"clustered":[69],"data,":[72],"other":[75],"display":[77],"enrichment":[78],"analysis":[79],"results":[80],"30":[82],"different":[83],"set":[85],"libraries.":[86],"Clicking":[87],"on":[88],"experimental":[90],"condition":[91],"highlights":[92],"gene-sets":[93],"enriched":[94],"for":[95,132,136],"differentially":[97],"expressed":[98],"genes":[99],"from":[100],"selected":[102],"experiment.":[103],"A":[104],"search":[105],"interface":[106],"allows":[107],"users":[108],"input":[110],"lists":[112],"query":[114],"them":[115],"against":[116],"over":[117],"100":[118],"000":[119],"conditions":[120],"find":[122],"top":[124],"matching":[125],"experiments.":[126],"tool":[128],"integrates":[129],"resources":[131],"unprecedented":[134],"potential":[135],"new":[137],"discoveries":[138],"systems":[140,143],"biology":[141],"pharmacology.":[144],"at":[150],"http://www.maayanlab.net/LINCS/LCB.":[151],"Customized":[152],"versions":[153],"will":[154],"be":[155],"made":[156],"part":[157],"http://lincscloud.org":[160],"http://lincs.hms.harvard.edu":[162],"websites.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":44},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":39},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}