{"id":"https://openalex.org/W2956586889","doi":"https://doi.org/10.1093/bioinformatics/btz336","title":"Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors","display_name":"Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2956586889","doi":"https://doi.org/10.1093/bioinformatics/btz336","mag":"2956586889","pmid":"https://pubmed.ncbi.nlm.nih.gov/31510691"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz336","pdf_url":"https://watermark.silverchair.com/btz336.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJ9J9KF1HoWu9ZFIXAgEQgIICc6n0aL2yiMJp3WURBGgWsSOD8VdZDJMQ1nntmmGjhqe5kSIetc-hGTKuuWEvWJQN8b47oUsG8vkM-8tOMFernAUUoGMNAQ2ysk_cYaRFmvChPmSL5DJpbqbmR3EZMERd66DNwmVNJC0djmsZJ-KlCbrliUs45R06hwprj44MpgJxx6roZkvB3j4cjTYVIIVQowe2XuWC-gWnXBXoz1mJzCK4kj4ZbaU0W3s-ZFYQSSMSpupJOkcSbGbQ2vXcOZPr_asLOE2gl7Y8daVvAHlb6je6Mfh3Ts2c9VpYbj8isOVql42DsScYK4CbNvcT7Xdu1-9s-aZzkJiVVs8X_PahekFIqAjsRYne9oVpZGGVkdB3ALM1eLQMzeh9qhDA6m4FnIxBu9Eg_BXAsCU_WkZDqxqErsqHan5svOy3_pY8Pem1Jqdj8eDl1AisHf76QuXJ9UB-LsfTYOW87uCIVwYEsj6uO0jGJjYMA1t8CY42SBN6vvMYHcATo9OzFB6s5-Ch2XDXgRQ_7vJ648IHFd6JS3T2Xq6_2Ovi8OfP3HUMcDUUbU_vAEZPL2NIkoO4TNnlge0EhhdSyoCRT4goqkIpQm6LP6mzsBfuP0QKA_CxNELNqJa4uruIEOMB3J0UFYLaRGfcBuYyU7LSjSGPxiUBysa92jcd45NhkIZ8FWDncVliVX0dPeY_NJGTQH8qImP0Dzd_ciehkcAfKVps24zM_nQsw6Ba0g0Fs6DGj4irX_fPGBMUCtyXvoscqhVgwTmaz5XwbP8hJUVnc-VKzcrKaziO7fUSob-r8BAkjynUK0z8mq2Csrks29M6jZk6EnaDN-C99A","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://watermark.silverchair.com/btz336.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJ9J9KF1HoWu9ZFIXAgEQgIICc6n0aL2yiMJp3WURBGgWsSOD8VdZDJMQ1nntmmGjhqe5kSIetc-hGTKuuWEvWJQN8b47oUsG8vkM-8tOMFernAUUoGMNAQ2ysk_cYaRFmvChPmSL5DJpbqbmR3EZMERd66DNwmVNJC0djmsZJ-KlCbrliUs45R06hwprj44MpgJxx6roZkvB3j4cjTYVIIVQowe2XuWC-gWnXBXoz1mJzCK4kj4ZbaU0W3s-ZFYQSSMSpupJOkcSbGbQ2vXcOZPr_asLOE2gl7Y8daVvAHlb6je6Mfh3Ts2c9VpYbj8isOVql42DsScYK4CbNvcT7Xdu1-9s-aZzkJiVVs8X_PahekFIqAjsRYne9oVpZGGVkdB3ALM1eLQMzeh9qhDA6m4FnIxBu9Eg_BXAsCU_WkZDqxqErsqHan5svOy3_pY8Pem1Jqdj8eDl1AisHf76QuXJ9UB-LsfTYOW87uCIVwYEsj6uO0jGJjYMA1t8CY42SBN6vvMYHcATo9OzFB6s5-Ch2XDXgRQ_7vJ648IHFd6JS3T2Xq6_2Ovi8OfP3HUMcDUUbU_vAEZPL2NIkoO4TNnlge0EhhdSyoCRT4goqkIpQm6LP6mzsBfuP0QKA_CxNELNqJa4uruIEOMB3J0UFYLaRGfcBuYyU7LSjSGPxiUBysa92jcd45NhkIZ8FWDncVliVX0dPeY_NJGTQH8qImP0Dzd_ciehkcAfKVps24zM_nQsw6Ba0g0Fs6DGj4irX_fPGBMUCtyXvoscqhVgwTmaz5XwbP8hJUVnc-VKzcrKaziO7fUSob-r8BAkjynUK0z8mq2Csrks29M6jZk6EnaDN-C99A","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102847901","display_name":"Jiansheng Wu","orcid":"https://orcid.org/0000-0002-7941-9722"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiansheng Wu","raw_affiliation_strings":["School of Geographic and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing, China","Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Geographic and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]},{"raw_affiliation_string":"Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114037021","display_name":"Ben Liu","orcid":"https://orcid.org/0009-0003-7595-5258"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ben Liu","raw_affiliation_strings":["School of Telecommunication and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Telecommunication and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075949814","display_name":"Wallace Chan","orcid":"https://orcid.org/0000-0001-5104-4159"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace K B Chan","raw_affiliation_strings":["Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100911204","display_name":"Weijian Wu","orcid":"https://orcid.org/0009-0000-6221-0503"},"institutions":[{"id":"https://openalex.org/I163340411","display_name":"Hohai University","ror":"https://ror.org/01wd4xt90","country_code":"CN","type":"education","lineage":["https://openalex.org/I163340411"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijian Wu","raw_affiliation_strings":["College of Computer and Information, Hohai University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"College of Computer and Information, Hohai University, Nanjing, China","institution_ids":["https://openalex.org/I163340411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031842962","display_name":"Tao Pang","orcid":"https://orcid.org/0000-0001-5420-2060"},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Pang","raw_affiliation_strings":["Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101788068","display_name":"Haifeng Hu","orcid":"https://orcid.org/0000-0002-6585-3106"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifeng Hu","raw_affiliation_strings":["School of Telecommunication and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Telecommunication and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013940025","display_name":"Shancheng Yan","orcid":"https://orcid.org/0000-0003-2574-3479"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shancheng Yan","raw_affiliation_strings":["School of Geographic and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing, China","Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Geographic and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]},{"raw_affiliation_string":"Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101037644","display_name":"Xiaoyan Ke","orcid":"https://orcid.org/0009-0007-7526-3875"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]},{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyan Ke","raw_affiliation_strings":["Child Mental Health Research Center, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Child Mental Health Research Center, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100354659","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-2739-1916"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100354659","https://openalex.org/A5101037644"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210109791","https://openalex.org/I83519826"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6819,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68642387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"14","first_page":"i324","last_page":"i332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.5652863383293152},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.5578511953353882},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5387542843818665},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5159088373184204},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.5074335932731628},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.49088984727859497},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49015888571739197},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44521740078926086},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.41182103753089905},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4109157919883728},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3824772238731384},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.27745574712753296},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24808862805366516},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15343666076660156}],"concepts":[{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5652863383293152},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.5578511953353882},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5387542843818665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5159088373184204},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5074335932731628},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.49088984727859497},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49015888571739197},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44521740078926086},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.41182103753089905},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4109157919883728},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3824772238731384},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27745574712753296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24808862805366516},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15343666076660156},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btz336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz336","pdf_url":"https://watermark.silverchair.com/btz336.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJ9J9KF1HoWu9ZFIXAgEQgIICc6n0aL2yiMJp3WURBGgWsSOD8VdZDJMQ1nntmmGjhqe5kSIetc-hGTKuuWEvWJQN8b47oUsG8vkM-8tOMFernAUUoGMNAQ2ysk_cYaRFmvChPmSL5DJpbqbmR3EZMERd66DNwmVNJC0djmsZJ-KlCbrliUs45R06hwprj44MpgJxx6roZkvB3j4cjTYVIIVQowe2XuWC-gWnXBXoz1mJzCK4kj4ZbaU0W3s-ZFYQSSMSpupJOkcSbGbQ2vXcOZPr_asLOE2gl7Y8daVvAHlb6je6Mfh3Ts2c9VpYbj8isOVql42DsScYK4CbNvcT7Xdu1-9s-aZzkJiVVs8X_PahekFIqAjsRYne9oVpZGGVkdB3ALM1eLQMzeh9qhDA6m4FnIxBu9Eg_BXAsCU_WkZDqxqErsqHan5svOy3_pY8Pem1Jqdj8eDl1AisHf76QuXJ9UB-LsfTYOW87uCIVwYEsj6uO0jGJjYMA1t8CY42SBN6vvMYHcATo9OzFB6s5-Ch2XDXgRQ_7vJ648IHFd6JS3T2Xq6_2Ovi8OfP3HUMcDUUbU_vAEZPL2NIkoO4TNnlge0EhhdSyoCRT4goqkIpQm6LP6mzsBfuP0QKA_CxNELNqJa4uruIEOMB3J0UFYLaRGfcBuYyU7LSjSGPxiUBysa92jcd45NhkIZ8FWDncVliVX0dPeY_NJGTQH8qImP0Dzd_ciehkcAfKVps24zM_nQsw6Ba0g0Fs6DGj4irX_fPGBMUCtyXvoscqhVgwTmaz5XwbP8hJUVnc-VKzcrKaziO7fUSob-r8BAkjynUK0z8mq2Csrks29M6jZk6EnaDN-C99A","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31510691","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31510691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5588685","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6612825","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz336","pdf_url":"https://watermark.silverchair.com/btz336.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJ9J9KF1HoWu9ZFIXAgEQgIICc6n0aL2yiMJp3WURBGgWsSOD8VdZDJMQ1nntmmGjhqe5kSIetc-hGTKuuWEvWJQN8b47oUsG8vkM-8tOMFernAUUoGMNAQ2ysk_cYaRFmvChPmSL5DJpbqbmR3EZMERd66DNwmVNJC0djmsZJ-KlCbrliUs45R06hwprj44MpgJxx6roZkvB3j4cjTYVIIVQowe2XuWC-gWnXBXoz1mJzCK4kj4ZbaU0W3s-ZFYQSSMSpupJOkcSbGbQ2vXcOZPr_asLOE2gl7Y8daVvAHlb6je6Mfh3Ts2c9VpYbj8isOVql42DsScYK4CbNvcT7Xdu1-9s-aZzkJiVVs8X_PahekFIqAjsRYne9oVpZGGVkdB3ALM1eLQMzeh9qhDA6m4FnIxBu9Eg_BXAsCU_WkZDqxqErsqHan5svOy3_pY8Pem1Jqdj8eDl1AisHf76QuXJ9UB-LsfTYOW87uCIVwYEsj6uO0jGJjYMA1t8CY42SBN6vvMYHcATo9OzFB6s5-Ch2XDXgRQ_7vJ648IHFd6JS3T2Xq6_2Ovi8OfP3HUMcDUUbU_vAEZPL2NIkoO4TNnlge0EhhdSyoCRT4goqkIpQm6LP6mzsBfuP0QKA_CxNELNqJa4uruIEOMB3J0UFYLaRGfcBuYyU7LSjSGPxiUBysa92jcd45NhkIZ8FWDncVliVX0dPeY_NJGTQH8qImP0Dzd_ciehkcAfKVps24zM_nQsw6Ba0g0Fs6DGj4irX_fPGBMUCtyXvoscqhVgwTmaz5XwbP8hJUVnc-VKzcrKaziO7fUSob-r8BAkjynUK0z8mq2Csrks29M6jZk6EnaDN-C99A","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2126391795","display_name":null,"funder_award_id":"17KJA510003","funder_id":"https://openalex.org/F4320329893","funder_display_name":"Key University Science Research Project of Jiangsu Province"},{"id":"https://openalex.org/G4129813132","display_name":null,"funder_award_id":"81771478","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4947787081","display_name":null,"funder_award_id":"61872198","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5664010555","display_name":null,"funder_award_id":"61571233","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7747661902","display_name":null,"funder_award_id":"DBI1564756","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329893","display_name":"Key University Science Research Project of Jiangsu Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956586889.pdf","grobid_xml":"https://content.openalex.org/works/W2956586889.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W3219084","https://openalex.org/W1543911290","https://openalex.org/W1682431075","https://openalex.org/W1983478747","https://openalex.org/W1988037271","https://openalex.org/W1999798000","https://openalex.org/W2002011878","https://openalex.org/W2033757486","https://openalex.org/W2044834685","https://openalex.org/W2070384060","https://openalex.org/W2073110681","https://openalex.org/W2090631504","https://openalex.org/W2096141892","https://openalex.org/W2097620183","https://openalex.org/W2100257305","https://openalex.org/W2124776405","https://openalex.org/W2124954099","https://openalex.org/W2130479394","https://openalex.org/W2135046866","https://openalex.org/W2153693853","https://openalex.org/W2214665483","https://openalex.org/W2473238561","https://openalex.org/W2541170635","https://openalex.org/W2734982589","https://openalex.org/W2751756351","https://openalex.org/W2765153686","https://openalex.org/W2790322107","https://openalex.org/W4211083314","https://openalex.org/W4230049581","https://openalex.org/W6632713273","https://openalex.org/W6674848032","https://openalex.org/W6688357764","https://openalex.org/W6729055146"],"related_works":["https://openalex.org/W2382340815","https://openalex.org/W1972650408","https://openalex.org/W2551736466","https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W1135792216","https://openalex.org/W4402273478","https://openalex.org/W2594726310","https://openalex.org/W2105416365","https://openalex.org/W2355193834"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}