{"id":"https://openalex.org/W2949679909","doi":"https://doi.org/10.1093/bioinformatics/btz112","title":"SUBSTRA: Supervised Bayesian Patient Stratification","display_name":"SUBSTRA: Supervised Bayesian Patient Stratification","publication_year":2019,"publication_date":"2019-02-15","ids":{"openalex":"https://openalex.org/W2949679909","doi":"https://doi.org/10.1093/bioinformatics/btz112","mag":"2949679909","pmid":"https://pubmed.ncbi.nlm.nih.gov/30768166"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz112","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz112","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066797978","display_name":"Sahand Khakabimamaghani","orcid":"https://orcid.org/0000-0002-5178-0188"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sahand Khakabimamaghani","raw_affiliation_strings":["School of Computing Science, Simon Fraser University , Burnaby, BC, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University , Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068939321","display_name":"Yogeshwar Kelkar","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogeshwar D Kelkar","raw_affiliation_strings":["Computational Systems Immunology, Pfizer Worldwide R&D , Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Computational Systems Immunology, Pfizer Worldwide R&D , Cambridge, MA, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075297650","display_name":"Bruno M. Grande","orcid":"https://orcid.org/0000-0002-4621-1589"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]},{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bruno M Grande","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Simon Fraser University , Burnaby, BC, Canada","Genome Sciences Centre, British Columbia Cancer Agency , Vancouver, BC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Simon Fraser University , Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Genome Sciences Centre, British Columbia Cancer Agency , Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081644676","display_name":"Ryan D. Morin","orcid":"https://orcid.org/0000-0003-2932-7800"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]},{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ryan D Morin","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Simon Fraser University , Burnaby, BC, Canada","Genome Sciences Centre, British Columbia Cancer Agency , Vancouver, BC, Canada","School of Computing Science, Simon Fraser University , Burnaby, BC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Simon Fraser University , Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Genome Sciences Centre, British Columbia Cancer Agency , Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"School of Computing Science, Simon Fraser University , Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018267399","display_name":"Martin Ester","orcid":"https://orcid.org/0000-0001-7732-2815"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Martin Ester","raw_affiliation_strings":["School of Computing Science, Simon Fraser University , Burnaby, BC, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University , Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038688193","display_name":"Daniel Ziemek","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100293","display_name":"Pfizer (Germany)","ror":"https://ror.org/00m8w3m39","country_code":"DE","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210100293"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daniel Ziemek","raw_affiliation_strings":["Computational Systems Immunology, Pfizer Worldwide R&D , Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Systems Immunology, Pfizer Worldwide R&D , Berlin, Germany","institution_ids":["https://openalex.org/I4210100293"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018267399","https://openalex.org/A5038688193"],"corresponding_institution_ids":["https://openalex.org/I18014758","https://openalex.org/I4210100293"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.1529,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46460395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"35","issue":"18","first_page":"3263","last_page":"3272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7054617404937744},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6500857472419739},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.600121259689331},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5885432362556458},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5287772417068481},{"id":"https://openalex.org/keywords/population-stratification","display_name":"Population stratification","score":0.4914449453353882},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.48397326469421387},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.449587345123291},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1086122989654541}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7054617404937744},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6500857472419739},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.600121259689331},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5885432362556458},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5287772417068481},{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.4914449453353882},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.48397326469421387},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.449587345123291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1086122989654541},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz112","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz112","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30768166","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30768166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1538685017","https://openalex.org/W1598868309","https://openalex.org/W1891744697","https://openalex.org/W1902027874","https://openalex.org/W1979147243","https://openalex.org/W1984466107","https://openalex.org/W2039215669","https://openalex.org/W2041935553","https://openalex.org/W2043398720","https://openalex.org/W2099058255","https://openalex.org/W2112009981","https://openalex.org/W2112634639","https://openalex.org/W2132657976","https://openalex.org/W2160026116","https://openalex.org/W2167689714","https://openalex.org/W2432718434","https://openalex.org/W2521019907","https://openalex.org/W2558685994","https://openalex.org/W2739330662","https://openalex.org/W6684513754"],"related_works":["https://openalex.org/W1485630101","https://openalex.org/W2498017833","https://openalex.org/W2961085424","https://openalex.org/W2911288319","https://openalex.org/W4320505317","https://openalex.org/W2977900939","https://openalex.org/W2594661604","https://openalex.org/W2950197776","https://openalex.org/W4319300674","https://openalex.org/W3170889190"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}