{"id":"https://openalex.org/W2952106966","doi":"https://doi.org/10.1093/bioinformatics/btz064","title":"Variational infinite heterogeneous mixture model for semi-supervised clustering of heart enhancers","display_name":"Variational infinite heterogeneous mixture model for semi-supervised clustering of heart enhancers","publication_year":2019,"publication_date":"2019-02-06","ids":{"openalex":"https://openalex.org/W2952106966","doi":"https://doi.org/10.1093/bioinformatics/btz064","mag":"2952106966","pmid":"https://pubmed.ncbi.nlm.nih.gov/30753279"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz064","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz064","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3232/48975377/bioinformatics_35_18_3232.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3232/48975377/bioinformatics_35_18_3232.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044125964","display_name":"Tahmid Mehdi","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tahmid F Mehdi","raw_affiliation_strings":["Department of Computer Science, University of Toronto , Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025773918","display_name":"Gurdeep Singh","orcid":"https://orcid.org/0000-0003-2519-0456"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gurdeep Singh","raw_affiliation_strings":["Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007939943","display_name":"Jennifer A. Mitchell","orcid":"https://orcid.org/0000-0002-7147-4604"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jennifer A Mitchell","raw_affiliation_strings":["Centre for the Analysis of Genome Evolution and Function, University of Toronto , Toronto, ON, Canada","Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Centre for the Analysis of Genome Evolution and Function, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103251621","display_name":"Alan M. Moses","orcid":"https://orcid.org/0000-0001-7099-8257"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Alan M Moses","raw_affiliation_strings":["Centre for the Analysis of Genome Evolution and Function, University of Toronto , Toronto, ON, Canada","Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada","Department of Computer Science, University of Toronto , Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Centre for the Analysis of Genome Evolution and Function, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Cell & Systems Biology, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Computer Science, University of Toronto , Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103251621"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05008242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"35","issue":"18","first_page":"3232","last_page":"3239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.7310476899147034},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6924787163734436},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6571966409683228},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.6518871784210205},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6268302202224731},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.46906352043151855},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.45192477107048035},{"id":"https://openalex.org/keywords/dirichlet-process","display_name":"Dirichlet process","score":0.433943510055542},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4035831689834595},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.392630398273468},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37772423028945923},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22612443566322327},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20184502005577087},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09967455267906189},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09827873110771179}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7310476899147034},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6924787163734436},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6571966409683228},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.6518871784210205},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6268302202224731},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.46906352043151855},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.45192477107048035},{"id":"https://openalex.org/C2781280628","wikidata":"https://www.wikidata.org/wiki/Q5280766","display_name":"Dirichlet process","level":3,"score":0.433943510055542},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4035831689834595},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.392630398273468},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37772423028945923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22612443566322327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20184502005577087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09967455267906189},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09827873110771179},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btz064","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz064","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3232/48975377/bioinformatics_35_18_3232.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30753279","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30753279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6748727","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6748727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz064","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz064","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3232/48975377/bioinformatics_35_18_3232.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G2165548363","display_name":null,"funder_award_id":"Canada","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8284766523","display_name":null,"funder_award_id":"(NSERC)","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320336370","display_name":"Ontario Ministry of Research and Innovation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952106966.pdf","grobid_xml":"https://content.openalex.org/works/W2952106966.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1601795611","https://openalex.org/W1663973292","https://openalex.org/W1963981640","https://openalex.org/W1986586739","https://openalex.org/W1987971958","https://openalex.org/W2018363492","https://openalex.org/W2021186554","https://openalex.org/W2033201031","https://openalex.org/W2036619779","https://openalex.org/W2040686597","https://openalex.org/W2057230177","https://openalex.org/W2072169887","https://openalex.org/W2075016035","https://openalex.org/W2076154138","https://openalex.org/W2080972498","https://openalex.org/W2096751146","https://openalex.org/W2111452249","https://openalex.org/W2115836056","https://openalex.org/W2117792884","https://openalex.org/W2117974500","https://openalex.org/W2127498532","https://openalex.org/W2157750191","https://openalex.org/W2166851633","https://openalex.org/W2167776710","https://openalex.org/W2259938310","https://openalex.org/W2411526797","https://openalex.org/W2544924996","https://openalex.org/W2588342025","https://openalex.org/W2750304043","https://openalex.org/W2767734436","https://openalex.org/W2769418303","https://openalex.org/W2790193774","https://openalex.org/W2912500072","https://openalex.org/W2915985519","https://openalex.org/W2951901532","https://openalex.org/W4230875896","https://openalex.org/W4235169531","https://openalex.org/W4237780050","https://openalex.org/W4294562888","https://openalex.org/W6670973774","https://openalex.org/W6684578138"],"related_works":["https://openalex.org/W4386716613","https://openalex.org/W4293482264","https://openalex.org/W1614270630","https://openalex.org/W1605972624","https://openalex.org/W1833498382","https://openalex.org/W3030242110","https://openalex.org/W3194589442","https://openalex.org/W1602151161","https://openalex.org/W2972093345","https://openalex.org/W57376053"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}