{"id":"https://openalex.org/W2800484633","doi":"https://doi.org/10.1093/bioinformatics/bty199","title":"RWEN: response-weighted elastic net for prediction of chemosensitivity of cancer cell lines","display_name":"RWEN: response-weighted elastic net for prediction of chemosensitivity of cancer cell lines","publication_year":2018,"publication_date":"2018-04-10","ids":{"openalex":"https://openalex.org/W2800484633","doi":"https://doi.org/10.1093/bioinformatics/bty199","mag":"2800484633","pmid":"https://pubmed.ncbi.nlm.nih.gov/29688307"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/19/3332/25839490/bty199.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/19/3332/25839490/bty199.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055889746","display_name":"Amrita Basu","orcid":"https://orcid.org/0000-0001-5005-3803"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amrita Basu","raw_affiliation_strings":["Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049386288","display_name":"Ritwik Mitra","orcid":null},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ritwik Mitra","raw_affiliation_strings":["Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349055","display_name":"Han Liu","orcid":"https://orcid.org/0000-0002-7731-8258"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Liu","raw_affiliation_strings":["Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035618234","display_name":"Stuart L. Schreiber","orcid":"https://orcid.org/0000-0003-1922-7558"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart L Schreiber","raw_affiliation_strings":["Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021915671","display_name":"Paul A. Clemons","orcid":"https://orcid.org/0000-0002-1800-5112"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul A Clemons","raw_affiliation_strings":["Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021915671","https://openalex.org/A5049386288","https://openalex.org/A5055889746"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I20089843"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.2087,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.95020524,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"34","issue":"19","first_page":"3332","last_page":"3339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9678999781608582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11063","display_name":"Rough Sets and Fuzzy Logic","score":0.9484999775886536,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastic-net-regularization","display_name":"Elastic net regularization","score":0.713550329208374},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5096640586853027},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"Cancer cell lines","score":0.4759387969970703},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4222496449947357},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.41794902086257935},{"id":"https://openalex.org/keywords/net","display_name":"Net (polyhedron)","score":0.41757529973983765},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2829391658306122},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26934120059013367},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.25634902715682983},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21540778875350952},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10869631171226501},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.08738577365875244}],"concepts":[{"id":"https://openalex.org/C203868755","wikidata":"https://www.wikidata.org/wiki/Q5353562","display_name":"Elastic net regularization","level":3,"score":0.713550329208374},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5096640586853027},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4759387969970703},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4222496449947357},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.41794902086257935},{"id":"https://openalex.org/C14166107","wikidata":"https://www.wikidata.org/wiki/Q253829","display_name":"Net (polyhedron)","level":2,"score":0.41757529973983765},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2829391658306122},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26934120059013367},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.25634902715682983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21540778875350952},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10869631171226501},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.08738577365875244},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bty199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/19/3332/25839490/bty199.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29688307","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29688307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6157095","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6157095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/19/3332/25839490/bty199.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800484633.pdf","grobid_xml":"https://content.openalex.org/works/W2800484633.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W593633726","https://openalex.org/W1573647811","https://openalex.org/W1594031697","https://openalex.org/W1678356000","https://openalex.org/W1970604527","https://openalex.org/W1976401682","https://openalex.org/W1988790447","https://openalex.org/W2010441486","https://openalex.org/W2018663224","https://openalex.org/W2024311320","https://openalex.org/W2025749418","https://openalex.org/W2035465844","https://openalex.org/W2043398720","https://openalex.org/W2047028564","https://openalex.org/W2063212204","https://openalex.org/W2066233583","https://openalex.org/W2070534370","https://openalex.org/W2075490785","https://openalex.org/W2095741373","https://openalex.org/W2097360283","https://openalex.org/W2108068107","https://openalex.org/W2108933868","https://openalex.org/W2116200229","https://openalex.org/W2119821739","https://openalex.org/W2120204563","https://openalex.org/W2122189635","https://openalex.org/W2122646361","https://openalex.org/W2122825543","https://openalex.org/W2125789330","https://openalex.org/W2135046866","https://openalex.org/W2137130182","https://openalex.org/W2150577353","https://openalex.org/W2152883907","https://openalex.org/W2160068277","https://openalex.org/W2175970000","https://openalex.org/W2220553089","https://openalex.org/W2222618761","https://openalex.org/W2293825098","https://openalex.org/W2461427403","https://openalex.org/W2911964244","https://openalex.org/W4234173777","https://openalex.org/W4239510810","https://openalex.org/W4294541781","https://openalex.org/W6610017368","https://openalex.org/W6634147026","https://openalex.org/W6661315439","https://openalex.org/W6666521836"],"related_works":["https://openalex.org/W4213314600","https://openalex.org/W3211319599","https://openalex.org/W2954774635","https://openalex.org/W4292248859","https://openalex.org/W4388594321","https://openalex.org/W4221147225","https://openalex.org/W2148172612","https://openalex.org/W4392841950","https://openalex.org/W4399585498","https://openalex.org/W1819007357"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-03-06T13:50:29.536080","created_date":"2025-10-10T00:00:00"}
