{"id":"https://openalex.org/W2761069142","doi":"https://doi.org/10.1093/bioinformatics/btx650","title":"An omnibus test for differential distribution analysis of microbiome sequencing data","display_name":"An omnibus test for differential distribution analysis of microbiome sequencing data","publication_year":2017,"publication_date":"2017-10-11","ids":{"openalex":"https://openalex.org/W2761069142","doi":"https://doi.org/10.1093/bioinformatics/btx650","mag":"2761069142","pmid":"https://pubmed.ncbi.nlm.nih.gov/29040451"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx650","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx650","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/4/643/25117217/btx650.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/4/643/25117217/btx650.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100450167","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-1273-5624"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA","Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA"],"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084085982","display_name":"Emily A. King","orcid":"https://orcid.org/0000-0003-1877-8673"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily King","raw_affiliation_strings":["Department of Statistics, Iowa State University, Ames, IA, USA","Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Iowa State University, Ames, IA, USA","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074929533","display_name":"Rebecca A. Deek","orcid":"https://orcid.org/0000-0002-8783-4694"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Deek","raw_affiliation_strings":["Department of Biostatistics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001916237","display_name":"Zhi Wei","orcid":"https://orcid.org/0000-0001-6059-4267"},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhi Wei","raw_affiliation_strings":["Department of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397981","display_name":"Yue Yu","orcid":"https://orcid.org/0000-0002-7620-6078"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yue Yu","raw_affiliation_strings":["College of Medical Informatics, Chongqing Medical University, Chongqing, China","Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA"],"affiliations":[{"raw_affiliation_string":"College of Medical Informatics, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033728545","display_name":"Diane E. Grill","orcid":"https://orcid.org/0000-0002-8677-1724"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Grill","raw_affiliation_strings":["Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA"],"affiliations":[{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074015095","display_name":"Karla V. Ballman","orcid":"https://orcid.org/0000-0002-4492-0357"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karla Ballman","raw_affiliation_strings":["Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5001916237","https://openalex.org/A5100450167"],"corresponding_institution_ids":["https://openalex.org/I118118575","https://openalex.org/I1330342723"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.3539,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.93282125,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"34","issue":"4","first_page":"643","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.7534165382385254},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.6866838335990906},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.6678823232650757},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5553765892982483},{"id":"https://openalex.org/keywords/count-data","display_name":"Count data","score":0.5356603860855103},{"id":"https://openalex.org/keywords/negative-binomial-distribution","display_name":"Negative binomial distribution","score":0.5211712718009949},{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.4400680959224701},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43720319867134094},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.4336928725242615},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4051855504512787},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27775394916534424},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.22915509343147278},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18381285667419434},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18238100409507751},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17518308758735657},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.15138262510299683},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11457115411758423}],"concepts":[{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.7534165382385254},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6866838335990906},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.6678823232650757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5553765892982483},{"id":"https://openalex.org/C33643355","wikidata":"https://www.wikidata.org/wiki/Q5176731","display_name":"Count data","level":3,"score":0.5356603860855103},{"id":"https://openalex.org/C199335787","wikidata":"https://www.wikidata.org/wiki/Q743364","display_name":"Negative binomial distribution","level":3,"score":0.5211712718009949},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.4400680959224701},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43720319867134094},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.4336928725242615},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4051855504512787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27775394916534424},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22915509343147278},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18381285667419434},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18238100409507751},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17518308758735657},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.15138262510299683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11457115411758423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btx650","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx650","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/4/643/25117217/btx650.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29040451","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29040451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx650","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx650","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/4/643/25117217/btx650.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2761069142.pdf","grobid_xml":"https://content.openalex.org/works/W2761069142.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W755741475","https://openalex.org/W1523266228","https://openalex.org/W1968105193","https://openalex.org/W1972463480","https://openalex.org/W1979966476","https://openalex.org/W1999813764","https://openalex.org/W2004014148","https://openalex.org/W2014581807","https://openalex.org/W2026006003","https://openalex.org/W2071103029","https://openalex.org/W2081098333","https://openalex.org/W2085284704","https://openalex.org/W2105351532","https://openalex.org/W2110065044","https://openalex.org/W2112058982","https://openalex.org/W2114104545","https://openalex.org/W2120083902","https://openalex.org/W2122698216","https://openalex.org/W2133856765","https://openalex.org/W2139674591","https://openalex.org/W2141925314","https://openalex.org/W2143777796","https://openalex.org/W2145147745","https://openalex.org/W2147637673","https://openalex.org/W2149573313","https://openalex.org/W2152239989","https://openalex.org/W2162857215","https://openalex.org/W2169364567","https://openalex.org/W2179438025","https://openalex.org/W2325994949","https://openalex.org/W2334099820","https://openalex.org/W2335253632","https://openalex.org/W2398800349","https://openalex.org/W2461582275","https://openalex.org/W2567421046","https://openalex.org/W2581853214","https://openalex.org/W2612324143","https://openalex.org/W2796514099","https://openalex.org/W6631383449","https://openalex.org/W6732982888"],"related_works":["https://openalex.org/W2599805416","https://openalex.org/W3210390693","https://openalex.org/W4214644238","https://openalex.org/W2556931687","https://openalex.org/W3135460725","https://openalex.org/W2338849605","https://openalex.org/W3122903216","https://openalex.org/W2971731486","https://openalex.org/W2095810391","https://openalex.org/W2404800752"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}