{"id":"https://openalex.org/W2148686938","doi":"https://doi.org/10.1093/bioinformatics/btu005","title":"estMOI: estimating multiplicity of infection using parasite deep sequencing data","display_name":"estMOI: estimating multiplicity of infection using parasite deep sequencing data","publication_year":2014,"publication_date":"2014-01-17","ids":{"openalex":"https://openalex.org/W2148686938","doi":"https://doi.org/10.1093/bioinformatics/btu005","mag":"2148686938","pmid":"https://pubmed.ncbi.nlm.nih.gov/24443379"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/9/1292/48922695/bioinformatics_30_9_1292.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/9/1292/48922695/bioinformatics_30_9_1292.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028847736","display_name":"Samuel Assefa","orcid":"https://orcid.org/0009-0005-6676-4497"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Samuel A. Assefa","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069991592","display_name":"Mark D. Preston","orcid":"https://orcid.org/0000-0002-6506-3104"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark D. Preston","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021239624","display_name":"Susana Campino","orcid":"https://orcid.org/0000-0003-1403-6138"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susana Campino","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025012088","display_name":"Harold Ocholla","orcid":null},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harold Ocholla","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042257591","display_name":"Colin J. Sutherland","orcid":"https://orcid.org/0000-0003-1592-6407"},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin J. Sutherland","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048799943","display_name":"Taane G. Clark","orcid":"https://orcid.org/0000-0001-8985-9265"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Taane G. Clark","raw_affiliation_strings":["1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia"],"affiliations":[{"raw_affiliation_string":"1 London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK, 2Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK and 3Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Box 30096 BT3, Blantyre, Malawia","institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028847736"],"corresponding_institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210089966"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":7.0736,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.9719958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"30","issue":"9","first_page":"1292","last_page":"1294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10815","display_name":"Parasite Biology and Host Interactions","score":0.9828000068664551,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiplicity-of-infection","display_name":"Multiplicity of infection","score":0.8187217712402344},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7912862300872803},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.7079062461853027},{"id":"https://openalex.org/keywords/parasite-hosting","display_name":"Parasite hosting","score":0.5571503043174744},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.5369622111320496},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.5365000367164612},{"id":"https://openalex.org/keywords/deep-sequencing","display_name":"Deep sequencing","score":0.49800801277160645},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.49650436639785767},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4812564551830292},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.4777216613292694},{"id":"https://openalex.org/keywords/merozoite-surface-protein","display_name":"Merozoite surface protein","score":0.4758317768573761},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.45716702938079834},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4343080520629883},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4264207184314728},{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.3893555998802185},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29001063108444214},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.14128509163856506},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.11372801661491394},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10765993595123291},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.08415523171424866}],"concepts":[{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.8187217712402344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7912862300872803},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7079062461853027},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.5571503043174744},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5369622111320496},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5365000367164612},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.49800801277160645},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.49650436639785767},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4812564551830292},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4777216613292694},{"id":"https://openalex.org/C2777023991","wikidata":"https://www.wikidata.org/wiki/Q83138168","display_name":"Merozoite surface protein","level":5,"score":0.4758317768573761},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45716702938079834},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4343080520629883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4264207184314728},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.3893555998802185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29001063108444214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14128509163856506},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11372801661491394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10765993595123291},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08415523171424866},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btu005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/9/1292/48922695/bioinformatics_30_9_1292.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24443379","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24443379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:researchonline.lshtm.ac.uk:1472192","is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/ipmbsass.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:europepmc.org:2975778","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3998131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/9/1292/48922695/bioinformatics_30_9_1292.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1893022765","display_name":null,"funder_award_id":"MR/L008661/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148686938.pdf","grobid_xml":"https://content.openalex.org/works/W2148686938.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1985812034","https://openalex.org/W1997493309","https://openalex.org/W2020764092","https://openalex.org/W2022877329","https://openalex.org/W2083006765","https://openalex.org/W2116839011","https://openalex.org/W2127132117","https://openalex.org/W2135614196","https://openalex.org/W2135697415","https://openalex.org/W2140497101","https://openalex.org/W2143456696","https://openalex.org/W2182728669"],"related_works":["https://openalex.org/W2020764495","https://openalex.org/W4386154080","https://openalex.org/W4225919871","https://openalex.org/W2034969505","https://openalex.org/W4307353701","https://openalex.org/W2119076403","https://openalex.org/W2160140202","https://openalex.org/W2015243764","https://openalex.org/W2048135856","https://openalex.org/W2137545930"],"abstract_inverted_index":{"Individuals":[0],"living":[1],"in":[2,55,151],"endemic":[3],"areas":[4],"generally":[5],"harbour":[6],"multiple":[7,146],"parasite":[8,59],"strains.":[9],"Multiplicity":[10],"of":[11,18,33,63,81,85,106,121],"infection":[12],"(MOI)":[13],"can":[14,50,97],"be":[15,98],"an":[16],"indicator":[17],"immune":[19],"status":[20],"and":[21],"transmission":[22],"intensity.":[23],"It":[24],"has":[25],"a":[26,31,71,112],"potentially":[27],"confounding":[28],"effect":[29],"on":[30],"number":[32],"population":[34],"genetic":[35],"analyses,":[36],"which":[37,117],"often":[38],"assume":[39],"isolates":[40,139],"are":[41,148],"clonal.":[42],"Polymerase":[43],"chain":[44],"reaction-based":[45],"approaches":[46],"to":[47,114,136],"estimate":[48,115],"MOI":[49,96],"lack":[51],"sensitivity.":[52],"For":[53],"example,":[54],"the":[56,64,78,104,131],"human":[57],"malaria":[58],"Plasmodium":[60],"falciparum,":[61],"genotyping":[62],"merozoite":[65],"surface":[66],"protein":[67],"(MSP1/2)":[68],"genes":[69],"is":[70,128],"standard":[72],"method":[73,113,127],"for":[74],"assessing":[75],"MOI,":[76,116],"despite":[77],"apparent":[79],"problem":[80],"underestimation.":[82],"The":[83,126],"availability":[84],"deep":[86],"coverage":[87],"data":[88],"from":[89,123,140],"massively":[90],"parallizable":[91],"sequencing":[92],"technologies":[93],"means":[94],"that":[95,145],"detected":[99],"genome":[100],"wide":[101],"by":[102],"considering":[103],"abundance":[105],"heterozygous":[107],"genotypes.":[108],"Here,":[109],"we":[110,143],"present":[111],"considers":[118],"unique":[119],"combinations":[120],"polymorphisms":[122],"sequence":[124],"reads.":[125],"implemented":[129],"within":[130],"estMOI":[132],"software.":[133],"When":[134],"applied":[135],"clinical":[137],"P.falciparum":[138],"three":[141],"continents,":[142],"find":[144],"infections":[147],"common,":[149],"especially":[150],"regions":[152],"with":[153],"high":[154],"transmission.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}