{"id":"https://openalex.org/W2104313063","doi":"https://doi.org/10.1093/bioinformatics/btr018","title":"Biological assessment of robust noise models in microarray data analysis","display_name":"Biological assessment of robust noise models in microarray data analysis","publication_year":2011,"publication_date":"2011-01-19","ids":{"openalex":"https://openalex.org/W2104313063","doi":"https://doi.org/10.1093/bioinformatics/btr018","mag":"2104313063"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr018","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/6/807/643408/btr018.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/6/807/643408/btr018.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050918885","display_name":"Alexandra Posekany","orcid":null},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"A. Posekany","raw_affiliation_strings":["1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109554637","display_name":"K. Felsenstein","orcid":null},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K. Felsenstein","raw_affiliation_strings":["1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048093482","display_name":"Peter Sykacek","orcid":"https://orcid.org/0000-0001-8800-8354"},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"P. Sykacek","raw_affiliation_strings":["1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"1 Chair of Bioinformatics, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor Mendel Stra\u00dfe 33, 1180, Vienna and 2Department of Statistics, Vienna University of Technology, Karlsplatz 13, 1040 Vienna, Austria","institution_ids":["https://openalex.org/I92869138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050918885"],"corresponding_institution_ids":["https://openalex.org/I92869138"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.0009,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.86463753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"27","issue":"6","first_page":"807","last_page":"814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.616278886795044},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5844777822494507},{"id":"https://openalex.org/keywords/gaussian-noise","display_name":"Gaussian noise","score":0.5425252914428711},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4838951528072357},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4581635594367981},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.44350674748420715},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.42554694414138794},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40170684456825256},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.36137819290161133},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2959904670715332},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28837788105010986}],"concepts":[{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.616278886795044},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5844777822494507},{"id":"https://openalex.org/C4199805","wikidata":"https://www.wikidata.org/wiki/Q2725903","display_name":"Gaussian noise","level":2,"score":0.5425252914428711},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4838951528072357},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4581635594367981},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.44350674748420715},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.42554694414138794},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40170684456825256},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.36137819290161133},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2959904670715332},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28837788105010986},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btr018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr018","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/6/807/643408/btr018.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:research.wu.ac.at:openaire_cris_publications/b7fca7e4-1c9b-4080-873a-e71ca5004b74","is_oa":false,"landing_page_url":"https://research.wu.ac.at/de/publications/b7fca7e4-1c9b-4080-873a-e71ca5004b74","pdf_url":null,"source":{"id":"https://openalex.org/S7407055123","display_name":"WU Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Posekany, A, Felsenstein, K & Sykacek, P 2011, 'Biological Assessment of robust noise models in microarray data analysis', Bioinformatics, vol. 27, no. 6, pp. 807 - 814.","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:3051324","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3051324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr018","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/6/807/643408/btr018.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.5799999833106995,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104313063.pdf","grobid_xml":"https://content.openalex.org/works/W2104313063.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W158033641","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1549853756","https://openalex.org/W1935582206","https://openalex.org/W1969653471","https://openalex.org/W1971289666","https://openalex.org/W1985093013","https://openalex.org/W2005404109","https://openalex.org/W2006262937","https://openalex.org/W2020541351","https://openalex.org/W2021325384","https://openalex.org/W2039064403","https://openalex.org/W2047204673","https://openalex.org/W2047614255","https://openalex.org/W2051817458","https://openalex.org/W2061357003","https://openalex.org/W2075804287","https://openalex.org/W2084878514","https://openalex.org/W2100668965","https://openalex.org/W2103017472","https://openalex.org/W2103857951","https://openalex.org/W2105896055","https://openalex.org/W2106706098","https://openalex.org/W2107914050","https://openalex.org/W2109453886","https://openalex.org/W2111331733","https://openalex.org/W2111411240","https://openalex.org/W2114120667","https://openalex.org/W2114729479","https://openalex.org/W2115463832","https://openalex.org/W2120865735","https://openalex.org/W2121347941","https://openalex.org/W2122323371","https://openalex.org/W2122598723","https://openalex.org/W2122683221","https://openalex.org/W2123172482","https://openalex.org/W2123748412","https://openalex.org/W2124388496","https://openalex.org/W2126163471","https://openalex.org/W2130416410","https://openalex.org/W2130948145","https://openalex.org/W2134338931","https://openalex.org/W2137839010","https://openalex.org/W2143198897","https://openalex.org/W2144227498","https://openalex.org/W2146004021","https://openalex.org/W2147788240","https://openalex.org/W2157795344","https://openalex.org/W2158524254","https://openalex.org/W2158637945","https://openalex.org/W2158787958","https://openalex.org/W2161605223","https://openalex.org/W2161828876","https://openalex.org/W2170989872","https://openalex.org/W2186352679","https://openalex.org/W2212376992","https://openalex.org/W2486810026","https://openalex.org/W2767905780","https://openalex.org/W2911546748","https://openalex.org/W4232632925","https://openalex.org/W4249273120","https://openalex.org/W4251644969","https://openalex.org/W4292691288","https://openalex.org/W4294107304","https://openalex.org/W6632854936","https://openalex.org/W6675991570","https://openalex.org/W6686352926","https://openalex.org/W6892184452"],"related_works":["https://openalex.org/W2591697403","https://openalex.org/W2953716828","https://openalex.org/W2904857019","https://openalex.org/W2944728705","https://openalex.org/W3011538607","https://openalex.org/W2904022177","https://openalex.org/W2359348847","https://openalex.org/W4321441197","https://openalex.org/W1970319972","https://openalex.org/W2953254336"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Although":[2],"several":[3],"recently":[4],"proposed":[5],"analysis":[6,49,87,136],"packages":[7],"for":[8,237],"microarray":[9,47,72,212],"data":[10,48,213],"can":[11,214],"cope":[12],"with":[13,105],"heavy-tailed":[14,161,238],"noise,":[15],"many":[16],"applications":[17],"rely":[18],"on":[19,67,186],"Gaussian":[20,22,44,101],"assumptions.":[21],"noise":[23,45,65,79,162,180,210],"models":[24,66,80],"foster":[25],"computational":[26],"efficiency.":[27],"This":[28],"comes,":[29],"however,":[30],"at":[31,119,190],"the":[32,142,150,191,207,221],"expense":[33],"of":[34,43,54,71,76,78,88,99,108,111,135,149,179,193,223],"increased":[35],"sensitivity":[36],"to":[37,60],"outlying":[38],"observations.":[39],"Assessing":[40],"potential":[41],"insufficiencies":[42],"in":[46,156,211],"is":[50,81,115,164],"thus":[51],"important":[52],"and":[53,103,138,153,196,218],"general":[55],"interest.":[56],"Results:":[57],"We":[58,200],"propose":[59],"this":[61],"end":[62],"assessing":[63],"different":[64],"a":[68,84,97,100,120,132,160,165,169,183],"large":[69],"number":[70],"experiments.":[73],"The":[74],"goodness":[75],"fit":[77,167],"quantified":[82],"by":[83,229],"hierarchical":[85],"Bayesian":[86],"variance":[89],"model,":[90],"which":[91],"predicts":[92],"normalized":[93],"expression":[94],"values":[95],"as":[96],"mixture":[98],"density":[102],"t-distributions":[104],"adjustable":[106],"degrees":[107],"freedom.":[109],"Inference":[110],"differentially":[112],"expressed":[113],"genes":[114,195],"taken":[116],"into":[117],"consideration":[118],"second":[121],"mixing":[122],"level.":[123],"For":[124],"attaining":[125],"far":[126],"reaching":[127],"validity,":[128],"our":[129,203],"investigations":[130,173],"cover":[131],"wide":[133],"range":[134],"platforms":[137],"experimental":[139],"settings.":[140],"As":[141],"most":[143],"striking":[144],"result,":[145],"we":[146],"find":[147],"irrespective":[148],"chosen":[151],"preprocessing":[152],"normalization":[154],"method":[155],"all":[157],"experiments":[158],"that":[159,175,205,220,235],"model":[163,181],"better":[166],"than":[168],"simple":[170],"Gaussian.":[171],"Further":[172],"revealed":[174],"an":[176],"appropriate":[177],"choice":[178],"has":[182],"considerable":[184],"influence":[185],"biological":[187],"interpretations":[188],"drawn":[189],"level":[192],"inferred":[194],"gene":[197],"ontology":[198],"terms.":[199],"conclude":[201],"from":[202],"investigation":[204],"neglecting":[206],"over":[208],"dispersed":[209],"mislead":[215],"scientific":[216],"discovery":[217],"suggest":[219],"convenience":[222],"Gaussian-based":[224],"modelling":[225],"should":[226],"be":[227],"replaced":[228],"non-parametric":[230],"approaches":[231],"or":[232],"other":[233],"methods":[234],"account":[236],"noise.":[239],"Contact:":[240],"peter.sykacek@boku.ac.at":[241],"Availability:":[242],"http://bioinf.boku.ac.at/alexp/robmca.html.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
