{"id":"https://openalex.org/W2171295581","doi":"https://doi.org/10.1093/bioinformatics/btq551","title":"High-throughput prediction of protein antigenicity using protein microarray data","display_name":"High-throughput prediction of protein antigenicity using protein microarray data","publication_year":2010,"publication_date":"2010-10-07","ids":{"openalex":"https://openalex.org/W2171295581","doi":"https://doi.org/10.1093/bioinformatics/btq551","mag":"2171295581","pmid":"https://pubmed.ncbi.nlm.nih.gov/20934990"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq551","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/23/2936/48851078/bioinformatics_26_23_2936.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/23/2936/48851078/bioinformatics_26_23_2936.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085024037","display_name":"Chr\u0300istophe Magnan","orcid":"https://orcid.org/0000-0002-7044-2571"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe N. Magnan","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062614823","display_name":"Michael Zeller","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Zeller","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027582939","display_name":"Matthew A. Kayala","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Kayala","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036576839","display_name":"Adam Vigil","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Vigil","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113274636","display_name":"Arlo Randall","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlo Randall","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010232221","display_name":"Philip L. Felgner","orcid":"https://orcid.org/0000-0002-4117-8505"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip L. Felgner","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088813478","display_name":"Pierre Baldi","orcid":"https://orcid.org/0000-0001-8752-4664"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pierre Baldi","raw_affiliation_strings":["1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences and 2Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5088813478"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0843,"has_fulltext":false,"cited_by_count":529,"citation_normalized_percentile":{"value":0.7684083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"26","issue":"23","first_page":"2936","last_page":"2943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.7062970399856567},{"id":"https://openalex.org/keywords/antigenicity","display_name":"Antigenicity","score":0.7014956474304199},{"id":"https://openalex.org/keywords/protein-microarray","display_name":"Protein microarray","score":0.649358868598938},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.6353521347045898},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5685241222381592},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5629234910011292},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5101785659790039},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5016486644744873},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4615720510482788},{"id":"https://openalex.org/keywords/antibody-microarray","display_name":"Antibody microarray","score":0.46127012372016907},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.3566127419471741},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29142141342163086},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23029404878616333},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20444068312644958},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09638446569442749}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7062970399856567},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.7014956474304199},{"id":"https://openalex.org/C195814341","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein microarray","level":5,"score":0.649358868598938},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6353521347045898},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5685241222381592},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5629234910011292},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5101785659790039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5016486644744873},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4615720510482788},{"id":"https://openalex.org/C171196145","wikidata":"https://www.wikidata.org/wiki/Q4774577","display_name":"Antibody microarray","level":3,"score":0.46127012372016907},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3566127419471741},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29142141342163086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23029404878616333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20444068312644958},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09638446569442749}],"mesh":[{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btq551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq551","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/23/2936/48851078/bioinformatics_26_23_2936.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20934990","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20934990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2982151","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2982151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq551","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/23/2936/48851078/bioinformatics_26_23_2936.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171295581.pdf","grobid_xml":"https://content.openalex.org/works/W2171295581.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W154377515","https://openalex.org/W1534477342","https://openalex.org/W1558365920","https://openalex.org/W1570448133","https://openalex.org/W1680392829","https://openalex.org/W1795576732","https://openalex.org/W1844925375","https://openalex.org/W1863266496","https://openalex.org/W1975304761","https://openalex.org/W1983113740","https://openalex.org/W1991542542","https://openalex.org/W2005162839","https://openalex.org/W2006211612","https://openalex.org/W2017337590","https://openalex.org/W2034765632","https://openalex.org/W2042903553","https://openalex.org/W2046452372","https://openalex.org/W2053418558","https://openalex.org/W2055043387","https://openalex.org/W2058634586","https://openalex.org/W2063276338","https://openalex.org/W2066609648","https://openalex.org/W2068945309","https://openalex.org/W2068997255","https://openalex.org/W2069130539","https://openalex.org/W2075878132","https://openalex.org/W2084855813","https://openalex.org/W2087230890","https://openalex.org/W2096445115","https://openalex.org/W2096495474","https://openalex.org/W2097874743","https://openalex.org/W2102367710","https://openalex.org/W2106150646","https://openalex.org/W2106208567","https://openalex.org/W2107293196","https://openalex.org/W2115694019","https://openalex.org/W2116272367","https://openalex.org/W2117064132","https://openalex.org/W2119246926","https://openalex.org/W2122598723","https://openalex.org/W2124672930","https://openalex.org/W2125264382","https://openalex.org/W2129169740","https://openalex.org/W2129834345","https://openalex.org/W2131518260","https://openalex.org/W2131857238","https://openalex.org/W2133458779","https://openalex.org/W2137575262","https://openalex.org/W2144227498","https://openalex.org/W2149458203","https://openalex.org/W2149984099","https://openalex.org/W2152770371","https://openalex.org/W2153635508","https://openalex.org/W2158714788","https://openalex.org/W2158781610","https://openalex.org/W2158899863","https://openalex.org/W2160397907","https://openalex.org/W2164511624","https://openalex.org/W2167277498","https://openalex.org/W2168807719","https://openalex.org/W2170547166","https://openalex.org/W2171740232","https://openalex.org/W2531563875","https://openalex.org/W2774846296","https://openalex.org/W2966207845","https://openalex.org/W3120421331","https://openalex.org/W4211083314","https://openalex.org/W6634094483","https://openalex.org/W6637386731","https://openalex.org/W6639093311","https://openalex.org/W6677380243"],"related_works":["https://openalex.org/W2027863396","https://openalex.org/W2088609026","https://openalex.org/W2015797182","https://openalex.org/W2075468931","https://openalex.org/W2397924952","https://openalex.org/W2350540972","https://openalex.org/W4386592278","https://openalex.org/W2156589821","https://openalex.org/W412976701","https://openalex.org/W2007436533"],"abstract_inverted_index":{"MOTIVATION:":[0],"Discovery":[1],"of":[2,11,55,79,143,191,201],"novel":[3,42],"protective":[4,32,43,67,111,137,146],"antigens":[5,61,83,112,147],"is":[6,47,135,162,195],"fundamental":[7],"to":[8,39,64,121,128],"the":[9,60,114,130,144,152,159,188,198],"development":[10,190],"vaccines":[12],"for":[13,21,51,59,180],"existing":[14],"and":[15,108],"emerging":[16],"pathogens.":[17],"Most":[18],"computational":[19],"methods":[20,36,53],"predicting":[22],"protein":[23,105,134,153,182],"antigenicity":[24],"rely":[25],"directly":[26],"on":[27,158,175],"homology":[28],"with":[29],"previously":[30],"characterized":[31],"antigens;":[33],"however,":[34],"homology-based":[35],"will":[37],"fail":[38],"discover":[40],"truly":[41],"antigens.":[44],"Thus,":[45],"there":[46],"a":[48,66,86,123,133,136],"significant":[49],"need":[50],"homology-free":[52],"capable":[54],"screening":[56],"entire":[57],"proteomes":[58],"most":[62],"likely":[63],"generate":[65],"humoral":[68],"immune":[69],"response.":[70],"RESULTS:":[71],"Here":[72],"we":[73],"begin":[74],"by":[75,166],"curating":[76],"two":[77],"types":[78],"positive":[80],"data:":[81],"(i)":[82],"that":[84,132],"elicit":[85],"strong":[87],"antibody":[88],"response":[89],"in":[90,95,197],"protected":[91],"individuals":[92],"but":[93],"not":[94],"unprotected":[96],"individuals,":[97],"using":[98,150],"human":[99],"immunoglobulin":[100],"reactivity":[101],"data":[102,184],"obtained":[103,186],"from":[104,113],"microarray":[106,154,183],"analyses;":[107],"(ii)":[109],"known":[110,145],"literature.":[115],"The":[116,156],"resulting":[117],"datasets":[118],"are":[119],"used":[120],"train":[122],"sequence-based":[124],"prediction":[125],"model,":[126],"ANTIGENpro,":[127],"predict":[129],"likelihood":[131],"antigen.":[138],"ANTIGENpro":[139,170,194],"correctly":[140],"classifies":[141],"82%":[142],"when":[148,173],"trained":[149],"only":[151],"datasets.":[155],"accuracy":[157],"combined":[160],"dataset":[161],"estimated":[163],"at":[164,204],"76%":[165],"cross-validation":[167],"experiments.":[168],"Finally,":[169],"performs":[171],"well":[172],"evaluated":[174],"an":[176],"external":[177],"pathogen":[178],"proteome":[179],"which":[181],"were":[185],"after":[187],"initial":[189],"ANTIGENpro.":[192],"AVAILABILITY:":[193],"integrated":[196],"SCRATCH":[199],"suite":[200],"predictors":[202],"available":[203],"http://scratch.proteomics.ics.uci.edu.":[205],"CONTACT:":[206],"pfbaldi@ics.uci.edu":[207]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":57},{"year":2024,"cited_by_count":93},{"year":2023,"cited_by_count":63},{"year":2022,"cited_by_count":81},{"year":2021,"cited_by_count":80},{"year":2020,"cited_by_count":68},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}