{"id":"https://openalex.org/W2121913091","doi":"https://doi.org/10.1093/bioinformatics/btq127","title":"Alignment-free local structural search by writhe decomposition","display_name":"Alignment-free local structural search by writhe decomposition","publication_year":2010,"publication_date":"2010-04-05","ids":{"openalex":"https://openalex.org/W2121913091","doi":"https://doi.org/10.1093/bioinformatics/btq127","mag":"2121913091","pmid":"https://pubmed.ncbi.nlm.nih.gov/20371498"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq127","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/9/1176/48856517/bioinformatics_26_9_1176.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/9/1176/48856517/bioinformatics_26_9_1176.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012354604","display_name":"Degui Zhi","orcid":"https://orcid.org/0000-0001-7754-1890"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Degui Zhi","raw_affiliation_strings":["1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108358528","display_name":"Maxim Shatsky","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxim Shatsky","raw_affiliation_strings":["1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046334676","display_name":"Steven E. Brenner","orcid":"https://orcid.org/0000-0001-7559-6185"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Brenner","raw_affiliation_strings":["1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant and Microbial Biology, UC Berkeley and 2 Physical Biosciences Division, LBNL, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012354604"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.2711,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.60059713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"9","first_page":"1176","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/writhe","display_name":"Writhe","score":0.9296164512634277},{"id":"https://openalex.org/keywords/decomposition","display_name":"Decomposition","score":0.6199780702590942},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.45716536045074463},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39501678943634033},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.38482409715652466},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.35893481969833374},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2928895056247711},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19519689679145813},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.1298922300338745},{"id":"https://openalex.org/keywords/twist","display_name":"Twist","score":0.10478392243385315}],"concepts":[{"id":"https://openalex.org/C78555687","wikidata":"https://www.wikidata.org/wiki/Q778947","display_name":"Writhe","level":3,"score":0.9296164512634277},{"id":"https://openalex.org/C124681953","wikidata":"https://www.wikidata.org/wiki/Q339062","display_name":"Decomposition","level":2,"score":0.6199780702590942},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.45716536045074463},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39501678943634033},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.38482409715652466},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.35893481969833374},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2928895056247711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19519689679145813},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.1298922300338745},{"id":"https://openalex.org/C2776196297","wikidata":"https://www.wikidata.org/wiki/Q17138781","display_name":"Twist","level":2,"score":0.10478392243385315},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btq127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq127","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/9/1176/48856517/bioinformatics_26_9_1176.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20371498","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20371498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:osti.gov:1625265","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1625265","pdf_url":"https://www.osti.gov/servlets/purl/1625265","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2859133","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2859133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq127","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/9/1176/48856517/bioinformatics_26_9_1176.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6986553610","display_name":null,"funder_award_id":"AC03 76SF00098","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121913091.pdf","grobid_xml":"https://content.openalex.org/works/W2121913091.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W42190837","https://openalex.org/W1490138956","https://openalex.org/W1575541347","https://openalex.org/W1851262865","https://openalex.org/W1966521833","https://openalex.org/W1970728584","https://openalex.org/W1972148314","https://openalex.org/W1975453400","https://openalex.org/W1986594702","https://openalex.org/W1993273781","https://openalex.org/W1997406207","https://openalex.org/W2024519892","https://openalex.org/W2034669559","https://openalex.org/W2042516820","https://openalex.org/W2049355199","https://openalex.org/W2050330741","https://openalex.org/W2050956531","https://openalex.org/W2053289437","https://openalex.org/W2071037669","https://openalex.org/W2081771568","https://openalex.org/W2085277871","https://openalex.org/W2089052645","https://openalex.org/W2097108043","https://openalex.org/W2097311600","https://openalex.org/W2097617783","https://openalex.org/W2108067237","https://openalex.org/W2110397834","https://openalex.org/W2111691661","https://openalex.org/W2116268847","https://openalex.org/W2117077088","https://openalex.org/W2117499714","https://openalex.org/W2130083560","https://openalex.org/W2130479394","https://openalex.org/W2133225033","https://openalex.org/W2133657429","https://openalex.org/W2137146016","https://openalex.org/W2139753312","https://openalex.org/W2145275077","https://openalex.org/W2148823738","https://openalex.org/W2150434889","https://openalex.org/W2151785844","https://openalex.org/W2152326664","https://openalex.org/W2911573709","https://openalex.org/W6601694875","https://openalex.org/W6638732216","https://openalex.org/W6677651794"],"related_works":["https://openalex.org/W1993874841","https://openalex.org/W2950670000","https://openalex.org/W1992837242","https://openalex.org/W2055728653","https://openalex.org/W2137350151","https://openalex.org/W2181472531","https://openalex.org/W4321503635","https://openalex.org/W2013546677","https://openalex.org/W4321853974","https://openalex.org/W2105682380"],"abstract_inverted_index":{"MOTIVATION:":[0],"Rapid":[1],"methods":[2,29,42,65,80,154,172],"for":[3,32],"protein":[4,26],"structure":[5,45],"search":[6,39,113],"enable":[7],"biological":[8],"discoveries":[9],"based":[10],"on":[11],"flexibly":[12],"defined":[13],"structural":[14,37,74,109,112],"similarity,":[15],"unleashing":[16],"the":[17,20,33,186],"power":[18],"of":[19,24,35,127,157,162],"ever":[21],"greater":[22],"number":[23,126],"solved":[25],"structures.":[27],"Projection":[28,41],"show":[30,144],"promise":[31],"development":[34],"fast":[36],"database":[38],"solutions.":[40],"map":[43],"a":[44,47,50,67,96,117,124,137,174],"to":[46,89],"point":[48],"in":[49,70,136,155,173],"high-dimensional":[51],"space":[52],"and":[53],"compare":[54],"two":[55],"structures":[56,133],"by":[57,116],"measuring":[58],"distance":[59],"between":[60],"their":[61],"projected":[62],"points.":[63],"These":[64],"offer":[66],"tremendous":[68],"increase":[69],"speed":[71],"over":[72,151],"residue-level":[73],"alignment":[75],"methods.":[76],"However,":[77],"current":[78],"projection":[79,153,171],"are":[81,87,134],"not":[82],"practical,":[83],"partly":[84],"because":[85],"they":[86],"unable":[88],"identify":[90],"local":[91,108],"similarities.":[92,110],"RESULTS:":[93],"We":[94],"propose":[95],"new":[97],"projection-based":[98],"approach":[99],"that":[100,122,131,145],"can":[101],"rapidly":[102],"detect":[103],"global":[104],"as":[105,107],"well":[106],"Local":[111],"is":[114,183],"enabled":[115],"topology-inspired":[118],"writhe":[119],"decomposition":[120],"protocol":[121],"produces":[123],"small":[125],"fragments":[128],"while":[129,165],"ensuring":[130],"similar":[132,138],"cut":[135],"manner.":[139],"In":[140],"benchmark":[141,177],"tests,":[142],"we":[143],"our":[146],"method,":[147],"writher,":[148],"improves":[149],"accuracy":[150,167],"existing":[152,170],"terms":[156],"recognizing":[158],"scop":[159],"domains":[160],"out":[161],"multi-domain":[163],"proteins,":[164],"maintaining":[166],"comparable":[168],"with":[169],"standard":[175],"single-domain":[176],"test.":[178],"AVAILABILITY:":[179],"The":[180],"source":[181],"code":[182],"available":[184],"at":[185],"following":[187],"website:":[188],"http://compbio.berkeley.edu/proj/writher/.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
