{"id":"https://openalex.org/W2169533028","doi":"https://doi.org/10.1093/bioinformatics/btp710","title":"GWAF: an R package for genome-wide association analyses with family data","display_name":"GWAF: an R package for genome-wide association analyses with family data","publication_year":2009,"publication_date":"2009-12-29","ids":{"openalex":"https://openalex.org/W2169533028","doi":"https://doi.org/10.1093/bioinformatics/btp710","mag":"2169533028","pmid":"https://pubmed.ncbi.nlm.nih.gov/20040588"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp710","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/580/48855250/bioinformatics_26_4_580.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/580/48855250/bioinformatics_26_4_580.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018744948","display_name":"Ming\u2010Huei Chen","orcid":"https://orcid.org/0000-0003-3551-8726"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming-Huei Chen","raw_affiliation_strings":["1 Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 2 The National Heart, Lung, Blood Institute's Framingham Heart Study, Framingham, MA 01702 and 3 Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 2 The National Heart, Lung, Blood Institute's Framingham Heart Study, Framingham, MA 01702 and 3 Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I4210123017","https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101664374","display_name":"Qiong Yang","orcid":"https://orcid.org/0000-0002-3658-1375"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiong Yang","raw_affiliation_strings":["1 Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 2 The National Heart, Lung, Blood Institute's Framingham Heart Study, Framingham, MA 01702 and 3 Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 2 The National Heart, Lung, Blood Institute's Framingham Heart Study, Framingham, MA 01702 and 3 Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I4210123017","https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018744948"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":10.5306,"has_fulltext":false,"cited_by_count":207,"citation_normalized_percentile":{"value":0.98651856,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"26","issue":"4","first_page":"580","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7229123115539551},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6968346238136292},{"id":"https://openalex.org/keywords/framingham-heart-study","display_name":"Framingham Heart Study","score":0.6790300607681274},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.6516565084457397},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.6509284973144531},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5881443023681641},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.548004150390625},{"id":"https://openalex.org/keywords/association-test","display_name":"Association test","score":0.50174880027771},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45258036255836487},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.338923841714859},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30659377574920654},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30397993326187134},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1253722608089447},{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham Risk Score","score":0.12028789520263672},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.10053184628486633},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06629547476768494}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7229123115539551},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6968346238136292},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.6790300607681274},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.6516565084457397},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.6509284973144531},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5881443023681641},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.548004150390625},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.50174880027771},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45258036255836487},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.338923841714859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30659377574920654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30397993326187134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1253722608089447},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.12028789520263672},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.10053184628486633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06629547476768494},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp710","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/580/48855250/bioinformatics_26_4_580.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20040588","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20040588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2040787","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2852219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp710","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/580/48855250/bioinformatics_26_4_580.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309647","display_name":"School of Medicine, Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169533028.pdf","grobid_xml":"https://content.openalex.org/works/W2169533028.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1524548598","https://openalex.org/W2008047653","https://openalex.org/W2115335486","https://openalex.org/W2149860264"],"related_works":["https://openalex.org/W3132297604","https://openalex.org/W1587862541","https://openalex.org/W1987313132","https://openalex.org/W2098504414","https://openalex.org/W2791348740","https://openalex.org/W1844241564","https://openalex.org/W1601337698","https://openalex.org/W4386270476","https://openalex.org/W2137089630","https://openalex.org/W2891543479"],"abstract_inverted_index":{"GWAF,":[0],"Genome-Wide":[1],"Association":[2,83],"analyses":[3],"with":[4,34,72],"Family,":[5],"is":[6],"an":[7],"R":[8],"package":[9],"designed":[10],"for":[11],"GWAF.":[12],"It":[13],"implements":[14],"association":[15],"tests":[16],"between":[17],"a":[18,29,58,63],"batch":[19],"of":[20],"genotyped":[21],"or":[22,31],"imputed":[23],"single":[24],"nucleotide":[25],"polymorphisms":[26],"(SNPs)":[27],"and":[28,39,62],"binary":[30,64],"continuous":[32,60,70],"trait":[33,61,65,71],"user":[35],"specified":[36],"genetic":[37],"model,":[38],"generates":[40],"informative":[41],"results":[42],"from":[43,67,76],"the":[44,68,77],"analyses.":[45],"In":[46],"addition,":[47],"GWAF":[48,56],"provides":[49],"functions":[50],"to":[51],"visualize":[52],"results.":[53],"We":[54],"evaluated":[55],"using":[57],"simulated":[59,69],"dichotomized":[66],"real":[73],"genotype":[74],"data":[75],"Framingham":[78],"Heart":[79],"Study's":[80],"SNP":[81],"Health":[82],"Resource":[84],"project.":[85]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":23}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
