{"id":"https://openalex.org/W2095833325","doi":"https://doi.org/10.1093/bioinformatics/btn660","title":"Differential dependency network analysis to identify condition-specific topological changes in biological networks","display_name":"Differential dependency network analysis to identify condition-specific topological changes in biological networks","publication_year":2008,"publication_date":"2008-12-26","ids":{"openalex":"https://openalex.org/W2095833325","doi":"https://doi.org/10.1093/bioinformatics/btn660","mag":"2095833325","pmid":"https://pubmed.ncbi.nlm.nih.gov/19112081"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn660","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn660","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/4/526/48984368/bioinformatics_25_4_526.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/4/526/48984368/bioinformatics_25_4_526.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065836602","display_name":"Bai Zhang","orcid":"https://orcid.org/0000-0003-4006-7640"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bai Zhang","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074947237","display_name":"Huai Li","orcid":"https://orcid.org/0000-0001-7129-6660"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huai Li","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032949456","display_name":"Rebecca B. Riggins","orcid":"https://orcid.org/0000-0002-1555-4431"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca B. Riggins","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","GEORGETOWN UNIVERSITY"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028221595","display_name":"Ming Zhan","orcid":"https://orcid.org/0000-0002-4668-727X"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhan","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536121","display_name":"Jianhua Xuan","orcid":"https://orcid.org/0000-0001-7256-1374"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Xuan","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390131","display_name":"Zhen Zhang","orcid":"https://orcid.org/0000-0001-6335-9529"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zhang","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088688","display_name":"Eric P. Hoffman","orcid":"https://orcid.org/0000-0001-6470-5139"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P. Hoffman","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011322600","display_name":"Robert Clarke","orcid":"https://orcid.org/0000-0002-9278-0854"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Clarke","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","GEORGETOWN UNIVERSITY"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646917","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-5741-498X"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I184565670","https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5065836602"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1336742384","https://openalex.org/I145311948","https://openalex.org/I184565670","https://openalex.org/I4210136897"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.798,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.84489373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"25","issue":"4","first_page":"526","last_page":"532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.663933515548706},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6283262968063354},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.618583083152771},{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.604050874710083},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5492366552352905},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.4699347913265228},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4561235010623932},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43357929587364197},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28151804208755493},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2483271360397339},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24008110165596008},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15148887038230896},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12324777245521545}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.663933515548706},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6283262968063354},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.618583083152771},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.604050874710083},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5492366552352905},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.4699347913265228},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4561235010623932},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43357929587364197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28151804208755493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2483271360397339},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24008110165596008},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15148887038230896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12324777245521545},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn660","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn660","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/4/526/48984368/bioinformatics_25_4_526.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19112081","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19112081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:1941655","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642641","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn660","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn660","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/4/526/48984368/bioinformatics_25_4_526.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1144149631","display_name":null,"funder_award_id":"BC030280","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2974495216","display_name":null,"funder_award_id":"CA109872","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3283202979","display_name":null,"funder_award_id":"EB000830","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6138437844","display_name":null,"funder_award_id":"BC030280","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2095833325.pdf","grobid_xml":"https://content.openalex.org/works/W2095833325.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W560903979","https://openalex.org/W606461409","https://openalex.org/W1491772324","https://openalex.org/W1520983351","https://openalex.org/W1554805217","https://openalex.org/W1605507149","https://openalex.org/W1851422093","https://openalex.org/W1977868384","https://openalex.org/W1978486653","https://openalex.org/W1990494460","https://openalex.org/W1995945562","https://openalex.org/W2010824638","https://openalex.org/W2012881624","https://openalex.org/W2014073178","https://openalex.org/W2035530476","https://openalex.org/W2038302740","https://openalex.org/W2059054195","https://openalex.org/W2060393046","https://openalex.org/W2061954309","https://openalex.org/W2062141110","https://openalex.org/W2062753954","https://openalex.org/W2063978378","https://openalex.org/W2069645361","https://openalex.org/W2069733150","https://openalex.org/W2070672503","https://openalex.org/W2072569268","https://openalex.org/W2075095232","https://openalex.org/W2078167812","https://openalex.org/W2081857846","https://openalex.org/W2084833542","https://openalex.org/W2089595068","https://openalex.org/W2094366341","https://openalex.org/W2095622082","https://openalex.org/W2098837223","https://openalex.org/W2102217018","https://openalex.org/W2112018984","https://openalex.org/W2116063398","https://openalex.org/W2116887561","https://openalex.org/W2121195642","https://openalex.org/W2122825543","https://openalex.org/W2125631472","https://openalex.org/W2126585177","https://openalex.org/W2126715263","https://openalex.org/W2135046866","https://openalex.org/W2138624698","https://openalex.org/W2139807849","https://openalex.org/W2141426082","https://openalex.org/W2146045333","https://openalex.org/W2146506956","https://openalex.org/W2146906901","https://openalex.org/W2146997276","https://openalex.org/W2150940164","https://openalex.org/W2159605359","https://openalex.org/W2160533336","https://openalex.org/W2163480486","https://openalex.org/W2165133998","https://openalex.org/W2167190345","https://openalex.org/W2170414736","https://openalex.org/W2172209768","https://openalex.org/W2182031655","https://openalex.org/W2611370172","https://openalex.org/W2997644599","https://openalex.org/W3098834468","https://openalex.org/W3106889297","https://openalex.org/W3147703121","https://openalex.org/W4285719527","https://openalex.org/W6631410601","https://openalex.org/W6682241100"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W2949927938","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4206945140","https://openalex.org/W4386628104","https://openalex.org/W2029387041","https://openalex.org/W2130939068","https://openalex.org/W3163717165"],"abstract_inverted_index":{"The":[0],"DDN":[1],"MATLAB":[2],"toolbox":[3],"and":[4],"experiment":[5],"data":[6],"are":[7],"available":[8],"at":[9],"http://www.cbil.ece.vt.edu/software.htm.":[10]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
